Antiphospholipid Antibodies Associated With Retinal Vascular Disease

Pulido, Jose; Ward, Lisa M.; Fishman, Gerald A.; Goodwin, James; Froelich, Christopher J.; Sanghvi, Jyoti

doi:10.1097/00006982-198707040-00002

Cited by 49 publications

(12 citation statements)

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“…There have been many case reports on the presence of antiphospholipid antibodies in patients with central retinal vein occlusion (Pulido et al 1987;Levine et al 1988;Kleiner et al 1989;Asherson et al 1989b;Snyers et al 1990;Castanon et al 1995;Abu el Asrar et al 1996). In one study of 44 consecutive patients with central retinal vein occlusion, no correlation between antiphospholipid antibodies and central retinal vein occlusion could be detected (Glacet Bernard et al 1994).…”

mentioning

confidence: 99%

Activated protein C resistance and anticoagulant proteins in young adults with central retinal vein occlusion

Larsson

Hillarp

Ólafsdóttir

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Background: Central retinal vein occlusion is a disease that is most common in old people, and often associated with atherosclerosis, hypertension, diabetes or glaucoma. Since these diseases are much less evident in young people, we wanted to investigate the prevalence of disorders in the most common anticoagulant proteins in a group of young patients with central retinal vein occlusion. Methods. 37 consecutive patients younger than 50 years and with a history of central retinal vein occlusion, were analysed for deficiencies of natural inhibitors of coagulation (protein C, S, and antithrombin III), plasminogen, resistance to activated protein C, and the presence of anticardiolipin or lupus anticoagulants. Results. Anticoagulant protein deficiencies were found in 4 patients (11%) and activated protein C resistance in 7 patients (19%). Anticardiolipin or lupus anticoagulants were not found in the patients. Conclusion: Activated protein C resistance and anticoagulant protein deficiencies seem to be important factors to the etiology to central retinal vein occlusion in young patients.

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mentioning

confidence: 99%

Activated protein C resistance and anticoagulant proteins in young adults with central retinal vein occlusion

Larsson

Hillarp

Ólafsdóttir

et al. 1999

Acta Ophthalmologica Scandinavica

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“…Ocul Oncol Pathol 2020;6:159-163 DOI: 10.1159/000501155 A synergistic effect between coagulation disorders and the development of CRVO has been recognized; hypercoagulable workup can include testing for homocysteine and anticardiolipin antibodies, activated protein C resistance, and factor V Leiden testing [7][8][9]. A prospective case-control study found that patients with RVO were more likely to have hyperhomocysteinemia compared to controls [7], although some suggest that this is relevant to CRVO and not branch RVO [10].…”

Section: Discussionmentioning

confidence: 99%

MEK Inhibitor-Associated Central Retinal Vein Occlusion Associated with Hyperhomocysteinemia and MTHFR Variants

et al. 2019

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Central retinal vein occlusion (CRVO) is a rare side effect of MEK inhibitors. • MEK inhibitor-associated CRVO may result in permanent drug discontinuation. Novel Insights• MEK inhibitor-associated CRVO may be associated with hyperhomocysteinemia, suggesting a potential role for hyperhomocysteinemia screening prior to initiation of MEK inhibitor therapy. • In this small cohort, MEK inhibitor-associated CRVO was associated with good visual recovery following intravitreous anti-VEGF. AbstractBackground: Central retinal vein occlusion (CRVO) is a visually threatening event that has rarely been observed in patients taking MEK1/2 inhibitors and that may necessitate permanent discontinuation of a potentially efficacious therapy. We investigated the clinical characteristics of CRVO in patients on mitogen-activated protein kinase kinase (MEK) inhibition to better understand their predisposing factors and clinical course. Case Series: This was a single-center, ret-inhibitor-associated CRVO is a rare event which can exhibit visual recovery after drug cessation and intravitreous anti-VEGF injections. In this cohort, it was associated with hyperhomocysteinemia and genetic mutations in MTHFR, suggesting a potential role for hyperhomocysteinemia screening prior to initiation of MEK inhibitor therapy.

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“…Workup is rarely recommended, however, in cases of unilateral retinal vascular occlusions, although these may occasionally represent the first manifestation of a systemic hypercoagulable state, especially in younger patients without otherwise identifiable risk factors for vascular occlusion. 27,28,[31][32][33][34][35][36][37][38][39][40][41] There remains disagreement within the literature, and at our own institution, about the importance of systemic laboratory workup in patients with unilateral CRVO. Prospective studies are needed to better define the role of systemic laboratory testing in unilateral central vein or artery occlusion and, more importantly, to demonstrate a treatment benefit in patients diagnosed with hypercoagulable disease, such as APAS, associated with a retinal vascular event.…”

Section: Discussionmentioning

confidence: 99%

Catastrophic Antiphospholipid Antibody Syndrome and Cocaine Abuse Associated With Bilateral Retinal Vascular Occlusions

Campbell

Burkholder

Dunn

2011

RETINAL Cases &Amp; Brief Reports

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Bilateral central retinal vein occlusion and central retinal artery occlusion have been rarely reported in the literature and are often associated with underlying thrombotic risk factors, such as antiphospholipid antibody syndrome. Workup for underlying hypercoagulability and/or cocaine use should be considered in atypical and bilateral cases of central vein or artery occlusion. In this case, bilateral central retinal artery and vein occlusions developed as manifestations of catastrophic antiphospholipid antibody syndrome, which has not been previously reported.

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Antiphospholipid Antibodies Associated With Retinal Vascular Disease

Cited by 49 publications

References 0 publications

Activated protein C resistance and anticoagulant proteins in young adults with central retinal vein occlusion

Activated protein C resistance and anticoagulant proteins in young adults with central retinal vein occlusion

MEK Inhibitor-Associated Central Retinal Vein Occlusion Associated with Hyperhomocysteinemia and MTHFR Variants

Catastrophic Antiphospholipid Antibody Syndrome and Cocaine Abuse Associated With Bilateral Retinal Vascular Occlusions

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