Catastrophic Antiphospholipid Antibody Syndrome and Cocaine Abuse Associated With Bilateral Retinal Vascular Occlusions

Campbell, J. Peter; Burkholder, Bryn M.; Dunn, James P.

doi:10.1097/icb.0b013e3181f66d3b

Cited by 8 publications

(8 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…22,26,27,32 APS has also been associated with central retinal vein occlusion, 7,23,27,32–46 branch retinal vein occlusion,, 24,25,34,37,41,45,47–51 central retinal artery occlusion and branch retinal artery occlusion, 37,43,52–58 or the coexistence of both arterial and venous bed thromboses in the same patient. 32,36,59–64 Venous stasis retinopathy, 65,66 vitreous 67,68 and intraretinal hemorrhages, 67 retinal vasculitis, 69,70 cotton wool spots, 67,71 neovascularization, 72 diffuse retinal periphlebitis, 73 choroidal infarction, 74 and unexplained choroidal embolization 75 were already described as case reports.…”

Section: Part II – Systematic Review Of Ophthalmological Manifestatiomentioning

confidence: 99%

Ophthalmologic manifestations in primary antiphospholipid syndrome patients: A cross-sectional analysis of a primary antiphospholipid syndrome cohort (APS-Rio) and systematic review of the literature

Franco

Medina

Balbi

et al. 2020

Lupus

View full text Add to dashboard Cite

Objective There is a broad spectrum of eye involvement in antiphospholipid syndrome (APS). The majority of descriptions are presented as case reports that include mostly APS patients secondary to systemic lupus erythematosus (SLE), with no compelling evidence in primary APS (PAPS). This study aimed to describe ocular manifestations in our well-defined PAPS cohort (APS-Rio) and then perform a systematic literature review (SLR) of ocular manifestations in patients with APS or positivity to aPL without SLE. Methods We retrospectively analyzed PAPS patients followed at our outpatient clinics. All patients fulfilled Sydney APS classification criteria (2006). We evaluated them for ocular symptoms and previous ocular diagnoses. Antiphospholipid antibodies and clinical APS manifestations were compared between patients with and without ocular manifestations. For the SLR, electronic databases were searched up to November 2019. Results We studied 105 PAPS patients; 90.5% were female and 56.2% were Caucasian. We found ocular manifestations in 37.1% of our cohort. Thrombosis was the main criteria manifestation (95.2%) and lupus anticoagulant was the most prevalent antibody. Ophthalmologic diagnoses were present in 7 patients, with 5 having retinal vessels thromboses. Amaurosis fugax was the leading complaint, present in 30 patients. In the univariate analysis, amaurosis fugax was related to livedo (p = 0.005), Raynaud’s phenomenon (p = 0.048) and the presence of anticardiolipin antibody (≥40 GPL/MPL) (p = 0.041). Hemianopia was associated with arterial hypertension (p = 0.049). In the multivariate analysis, the only association found was between livedo and amaurosis fugax (OR 4.09, 95%CI 1.5–11.11, p = 0.006). Our SLR incorporated 96 articles of ocular manifestations in patients with PAPS or positivity to aPL without SLE. Ocular findings varied from 5 to 88%, including anterior and posterior segments, orbital and neuro-ophthalmologic changes. Conclusion There is little evidence on ocular manifestations in PAPS. We described an association between livedo and amaurosis fugax. Prospective studies are needed to promote the best treatment and avoid blindness in PAPS patients.

show abstract

Section: Part II – Systematic Review Of Ophthalmological Manifestatiomentioning

confidence: 99%

Ophthalmologic manifestations in primary antiphospholipid syndrome patients: A cross-sectional analysis of a primary antiphospholipid syndrome cohort (APS-Rio) and systematic review of the literature

Franco

Medina

Balbi

et al. 2020

Lupus

View full text Add to dashboard Cite

show abstract

“…22 The location of the occlusion is also critical because the involvement of an artery that feeds the macula will lead to profound and definitive vision loss, as in Cases 14, 15, 18, and 23. 5,6,9,14 Choroidopathy was the second most frequent diagnosis in our series (n = 10). In cases of SLE, choroidopathy is usually a sign of active disease and may indicate the onset of SLE nephropathy.…”

Section: Discussionmentioning

confidence: 62%

“…2 The last publication from the international registry with information on ophthalmic manifestations dates from 2009; it reported retinal involvement in 7% of cases but did not provide a detailed description of the ophthalmologic prognosis. [3][4][5][6][7][8][9][10][11][12][13][14] The aim of our study was to describe the posterior ophthalmic findings of a consecutive case series of patients with CAPS and to compare our findings with the most recent data from the 500 patients included in the international CAPS Registry. 15…”

mentioning

confidence: 99%

Catastrophic Antiphospholipid Syndrome and Posterior Ocular Involvement

Morel

Bonnet

Mehawej

et al. 2021

Retina

View full text Add to dashboard Cite

Purpose: To describe the posterior ophthalmic manifestations of catastrophic antiphospholipid syndrome.Methods: Retrospective case series of patients presenting with catastrophic antiphospholipid syndrome and posterior segment ocular manifestations. The main outcomes were the type of posterior segment manifestations at catastrophic antiphospholipid syndrome diagnosis, specifically retinal vascular occlusion, vasculitis, or choroidopathy, and the final best-corrected visual acuity.Results: This study included 23 patients (11 cases treated by the authors and 12 published case reports); 21 (91%) of them female. Their median age at diagnosis was 28 years (range, 16-79 years). Ophthalmologic manifestations were usually bilateral (n = 19, 83%) and involved vascular occlusive retinopathy (n = 17, 74%), choroidopathy (n = 11, 48%), or retinal vasculitis (n = 1, 4%). Final best-corrected visual acuity was not significantly worse than the bestcorrected visual acuity at diagnosis (P = 0.16). Retinal vascular occlusions were associated with poorer final visual acuity than choroidopathy (P = 0.002). After a median follow-up of 14 months (range, 2-132 months), nearly half the patients (n = 11, 48%) had permanent vision loss including best-corrected visual acuity of ,20/400 for 4 patients.Conclusion: Posterior ophthalmic manifestations of catastrophic antiphospholipid syndrome were mainly bilateral retinal vascular occlusion, which had the worst visual prognosis, followed by choroidopathy and retinal vasculitis. Permanent visual loss was common.

show abstract

“…Chociaż do zajęcia tętnicy środkowej siatkówki dochodzi stosunkowo rzadko (ok. 6%), przebieg i rokowanie w przebiegu CAPS są zazwyczaj niepomyślne. W literaturze opisywano ciężkie przypadki obustronnego centralnego zamknięcia żył siatkówki oraz zamknięcie tętnicy środkowej siatkówki w przebiegu CAPS (14,15). Podobnie w opisywanym przez nas przypadku -zator gałęzi tętnicy środkowej siatkówki w OP stanowił jedną ze składowych APS o katastrofalnym przebiegu, obok zajęcia naczyń nerkowych i OUN.…”

Section: Omówienieunclassified

Ophthalmological manifestations in antiphospholid syndrome – case series

Ostrowska-Spaleniak¹,

Krix-Jachym²,

Rękas³

2019

View full text Add to dashboard Cite

Zespół antyfosfolipidowy (inaczej zespół Hughesa, ang. Antiphospholipid Syndrome-APS) jest autoimmunologiczną chorobą, która charakteryzuje się zakrzepicą żylną i/lub tętniczą, niepowodzeniami położniczymi oraz występowaniem w surowicy prozakrzepowych przeciwciał antyfosfolipidowych (ang. Antiphospholipid Antibodies-aPLA): antykoagulantu toczniowego (ang. Lupus Anticoagulant-LA), przeciwciał antykardiolipinowych (ang. Anticardiolipin Antibodies-aCL) i przeciwciał przeciwko β2-glikoproteinie I (anti-β2-glycoprotein I antibodies-aβ2-GPI). Wyróżnia się APS pierwotny-niezwiązany z innymi chorobami-oraz wtórny do chorób tkanki łącznej-najczęściej współwystępuje z toczniem rumieniowatym układowym (ang. Systemic Lupus Erythematosus-SLE) w 30-50% przypadków. W przebiegu APS może dojść do zajęcia naczyń tętniczych, żylnych i włosowatych we wszystkich narządach i tkankach, z tym jest związana bogata symptomatologia zespołu. Dominującym objawem jest zakrzepica żył głębokich kończyn dolnych, powikłana w połowie przypadków zatorowością płucną. Ostre lub przewlekłe stany niedokrwienne spowodowane zakrzepami

show abstract

Catastrophic Antiphospholipid Antibody Syndrome and Cocaine Abuse Associated With Bilateral Retinal Vascular Occlusions

Cited by 8 publications

References 39 publications

Ophthalmologic manifestations in primary antiphospholipid syndrome patients: A cross-sectional analysis of a primary antiphospholipid syndrome cohort (APS-Rio) and systematic review of the literature

Ophthalmologic manifestations in primary antiphospholipid syndrome patients: A cross-sectional analysis of a primary antiphospholipid syndrome cohort (APS-Rio) and systematic review of the literature

Catastrophic Antiphospholipid Syndrome and Posterior Ocular Involvement

Ophthalmological manifestations in antiphospholid syndrome – case series

Contact Info

Product

Resources

About