Antiphospholipid antibodies in autoimmune thyroid diseases

Mankaï, Amani; Melayah, Sarra; Bousetta, Syrine; Ghozzi, Mariam; Yacoub-Jemni, S.; Ghedira, Ibtissem

doi:10.1002/jcla.24788

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…Studies have shown that 22% of patients with primary antiphospholipid syndrome have hypothyroidism. [26] In contrast, multiple cohort studies suggest that the prevalence of positive serum antiphospholipid antibodies is also increased in patients with hyperthyroidism, [27,28] and there may be a specific association between thyroid dysfunction and primary antiphospholipid syndrome. Some studies have also discovered that (subclinical) hyperthyroidism and (subclinical) hypothyroidism are both found to be closely related to rheumatoid arthritis.…”

Section: Discussionmentioning

confidence: 99%

Association between thyroid dysfunction and venous thromboembolism: A systematic review and meta-analysis

et al. 2023

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Background: Thyroid dysfunction plays an important role in the development of cardiovascular disease. However, its relationship with venous thromboembolism (VTE) remains unclear. We performed a meta-analysis of published cohort and case-control studies to investigate the association between thyroid dysfunction and VTE comprehensively. Methods: Three reviewers independently searched EMbase, PubMed, China national knowledge infrastructure, and Cochrane Library databases for relevant articles from the time of database establishment to 01 October 2022 and identified all studies on thyroid dysfunction and VTE as studies of interest. Of the 2418 publications retrieved, we identified 10 articles with 15 studies that met our selection criteria. Pooled ORs and 95% confidence intervals were calculated using fixed- or random-effect models. Results: We pooled 8 studies by a fixed-effect model, which suggested an increased risk of VTE in patients with (subclinical) hyperthyroidism (OR 1.33, 95% CI: 1.29–1.38). In the other 7 studies on patients with (subclinical) hypothyroidism, the risk was similarly increased when pooled by a random-effect model (OR 1.52, 95% CI: 1.23–1.89). After sensitivity analysis and risk of bias analysis, the risk of VTE was still increased in both (subclinical) hyperthyroidism (OR 1.322, 95% CI: 1.278–1.368) and (subclinical) hypothyroidism (OR 1.74, 95% CI: 1.41–2.16). Conclusion: Patients with thyroid dysfunction have an increased risk of VTE. Therefore, it is recommended to perform thyroid function screening routinely in patients at high risk of VTE.

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Section: Discussionmentioning

confidence: 99%

Association between thyroid dysfunction and venous thromboembolism: A systematic review and meta-analysis

et al. 2023

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Antiphospholipid antibodies in autoimmune thyroid diseases

Mankaï

Melayah

Bousetta

et al. 2022

Clinical Laboratory Analysis

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Background Antiphospholipid (aPL) antibodies have been reported in several autoimmune diseases. The aim of this study was to evaluate the frequency of aPL (anti‐cardiolipin antibodies (aCL) and anti‐β2 glycoprotein I antibodies (aβ2GPI)) in patients with autoimmune thyroid diseases (AITD). Methods One hundred and ninety‐five patients with AITD (139 Hashimoto's thyroiditis (HT) patients and 56 Graves' disease (GD) patients) and 90 healthy blood donors (HBD) were studied. IgG, IgA and IgM aCL and aβ2GPI were determined by ELISA. Results One hundred fifty‐four AITD patients were women and 41 were men. Fifty‐six healthy subjects were women and 34 were men. The median age of patients and the control group was 45 and 38.5 years, respectively. The frequency of aPL was significantly higher in patients with AITD and in patients with HT than in HBD (33.3% vs 11.1%, p < 10−3 and 38.1% vs 11.1%, p < 10−3). The frequency of aPL in GD was significantly lower than in HT (21.4% vs 38.1%, p = 0.025). In patients with HT, aβ2GPI (34.5%) was significantly more frequent than aCL (13.6%) (p < 10−3). The frequency of aβ2GPI was significantly higher in patients with HT than in healthy population (34.5% vs 11.1%, p < 10−3). In HT patients, IgA isotype of aβ2GPI was significantly more common than in HBD and in GD patients (27.3% vs 7.8%, p < 10−3 and 27.3% vs 12.5%, p = 0.02, respectively). Conclusion aβ2GPI and not aCL were frequent in AITD. IgA was the predominant isotype of aβ2GPI. aβ2GPI‐IgA was more frequent in HT than in GD.

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Frequency of antithyroid antibodies in patients with primary biliary cholangitis

Ghozzi,

Mankai,

Chedly

et al. 2023

Laboratory Medicine

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Objective Primary biliary cholangitis (PBC) is an autoimmune disease of liver that may be associated with other conditions, including autoimmune thyroid diseases. We aimed to investigate the frequency of anti-thyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (TG-Ab), and anti–thyrotropin receptor antibodies (TSHR-Ab) in Tunisian patients with PBC. Methods Sera of 80 patients with PBC were collected over a 9-year period. A total of 189 healthy blood donors (HBD) were included in the control group. Measurements of TPO-Ab and TG-Ab were performed using indirect enzyme-linked immunosorbent assay (ELISA). Competitive ELISA was used to assess TSHR-Ab. Results Antithyroid antibodies (ATA) were significantly more frequent in PBC patients than in the control group (13.7% vs 1.6%; P < 10−3). Out of 11 patients with ATA, 10 (90.9%) were female. Nine patients and 2 HBD had TPO-Ab (11.2% vs 1%; P < 10−3). TG-Ab were more frequent in patients than in healthy subjects but the difference was not statistically significant (6.2% vs 1.6%; P = .1). TPO-Ab and TG-Ab were present together in 3 patients (3.7%). TSHR-Ab were absent in patients and controls. Conclusion This study shows that PBC is associated with a high frequency of ATA but not TG-Ab or TSHR-Ab.

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Antiphospholipid antibodies in autoimmune thyroid diseases

Cited by 3 publications

References 42 publications

Association between thyroid dysfunction and venous thromboembolism: A systematic review and meta-analysis

Association between thyroid dysfunction and venous thromboembolism: A systematic review and meta-analysis

Antiphospholipid antibodies in autoimmune thyroid diseases

Frequency of antithyroid antibodies in patients with primary biliary cholangitis

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