Antiphospholipid (Hughes) syndrome: insights for orthopedics

Abstract

Scope of APSThe antiphospholipid (Hughes) syndrome (APS) is recognized as an autoimmune condition characterized by a tendency to thrombosis and, in pregnancy, to recurrent pregnancy loss. The impact of APS is huge and is well documented in some medical fields such as neurology (strokes, migraine, memory loss), cardiology (cardiac ischemia, syndrome X, valve lesions), gastroenterology (abdominal angina), dermatology (skin ulceration and necrosis, livedo reticularis and racemosa) and nephrology (renal thrombotic microangiopathy).

Bone Involvement in Systemic Lupus Erythematosus

“…AVN may be an osteoarticular manifestation in primary antiphospholipid syndrome (APS), sometimes as a presenting feature; some of these patients may not have a history of GCs intake, suggesting a role for antiphospholipid antibodies (aPL) in the pathophysiology of AVN [ 44 , 45 , 46 , 47 , 52 ]. In addition, aPL may cause endothelial damage and act as a prothrombotic factor leading to microvascular thrombosis in terminal-end arteries, bone ischaemia and tissue death [ 44 , 45 , 46 , 55 ].…”

Molecular Biomarkers in Multiple Sclerosis and Its Related Disorders: A Critical Review

“…Antiphospholipid syndrome (APS, or Hughes syndrome) is a systemic autoantibody-mediated acquired thrombophilia that is characterized by the presence of antiphospholipid antibodies (APL) against phospholipid-binding plasma proteins, such as beta-2-glycoprotein I (b2GPI) [ 43 , 44 , 45 , 46 ]. Because of its neurological symptoms which include strokes, migraine, memory loss and the common clinical, laboratory and radiological features; it has the potential to be misdiagnosed with other neurological diseases especially MS [ 44 , 45 , 46 , 47 ].…”