Antiphospholipid Inner Ear Syndrome

Mouadeb, Debbie A.; Ruckenstein, Michael J.

doi:10.1097/01.mlg.0000158666.15447.37

Cited by 60 publications

(37 citation statements)

References 14 publications

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“…On the other hand Fattori et al [27], analysing the levels of autoantibodies against basal membrane proteins as well as collagen II, V and I, were not able to define any role of these antibodies in the pathogenesis of MD. More recently, the association between the presence of anti-phospholipid antibodies and audio-vestibular dysfunction has been reported [28]. Pendrin is a protein encoded by the Pendred syndrome (PDS) gene and expressed both in thyroid cells and the internal ear, and could act as a shared auto-antigen.…”

Section: Discussionmentioning

confidence: 99%

Possible association between thyroid autoimmunity and Menière's disease

Fattori¹,

Nacci²,

Dardano³

et al. 2008

Clinical and Experimental Immunology

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SummaryVarious aetiopathological mechanisms have been postulated to be at the root of Menière's disease (MD), and some data suggest that there may be also an underlying autoimmune factor. In fact, Menière patients manifest certain characteristics that are typical of autoimmune involvement association of particular human leucocyte antigen haplotypes, the presence of antibodies against internal ear antigens. In this study, we evaluated the association between thyroid autoimmunity and MD in a non-selected group of patients. We recruited 50 consecutive MD patients and two groups as controls: group A, 82 healthy volunteers; and group B, 50 subjects suffering from acute unilateral peripheral vestibulopathy. All subjects were submitted to instrumental assessment of cochlear-vestibular function and analysis of thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, anti-TSH receptor antibody (TR-Ab), anti-thyroperoxidase antibody (TPO-Ab) and antithyroglobulin antibody (Tg-Ab) in the blood. The prevalence of autoimmune thyroiditis in group B [6/50 (12%); 66·7% TPO-Ab and 33·3% Tg-Ab] was superimposable with the healthy controls [6/82 (7%); 66·7% TPO-Ab and 33·3% Tg-Ab]. In contrast, 38% of the MD patients (P = 0·0001 versus group A and group B) had significant autoantibody levels (68·4% TPO-Ab; 15·8% TPO-Ab + TR-Ab; 10·5% Tg-Ab; 5·2% TPO-Ab + Tg-Ab). Furthermore, 14% of the MD patients were hyperthyroid under l-thyroxine therapy, while no dysfunction was seen in the control groups. Overall, our data demonstrate a significant association between MD and thyroid autoimmunity, which suggests that an autoimmune factor is involved in the aetiopathogenesis of this disease. These findings suggest that it should be useful to submit MD patients to multi-disciplinary clinical investigation.

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Section: Discussionmentioning

confidence: 99%

Possible association between thyroid autoimmunity and Menière's disease

Fattori¹,

Nacci²,

Dardano³

et al. 2008

Clinical and Experimental Immunology

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“…However, their role, in particular that of antiphospholipid antibodies, should be further investigated [11]. More specifically, very recent studies [24,25] have suggested that antiphospholipid antibodies may play a role in the pathogenesis of SNHL [24,25].…”

Section: Discussionmentioning

confidence: 99%

Anti-68 kDa antibodies in autoimmune sensorineural hearing loss

Bonaguri¹,

Orsoni²,

Zavota³

et al. 2007

Autoimmunity

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“…In another recent study, Mouadeb et al [50], investigated the possible association between antiphospholipid antibodies and SNHL of unknown origin in a cohort of 168 patients. Forty-two patients (25%) had at least one elevated antiphospholipid antibody marker.…”

Section: Snhl and The Antiphospholipid Syndrome (Aps)mentioning

confidence: 99%

The autoimmune characteristics of progressive or sudden sensorineural hearing loss

2006

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Autoimmune sensorineural hearing loss (ASNHL) is a clinical syndrome that typically produces a bilateral rapidly progressive hearing loss. Autoantibodies and autoreactive T cells have been implicated in the etiopathogenesis of ASNHL. However, the identity of a specific or highly relevant inner-ear self-antigen is still required. In recent years, a role for antiphospholipid antibodies has been also suggested, assuming sudden/progressive hearing loss to be part of the primary antiphospholipid syndrome (APS). In this review, we address the need for specific diagnostic tools in order to establish an autoimmune origin for hearing loss. Moreover, the decision of whether anti-inflammatory drugs or anti-coagulation should be given is also discussed.

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Antiphospholipid Inner Ear Syndrome

Cited by 60 publications

References 14 publications

Possible association between thyroid autoimmunity and Menière's disease

Possible association between thyroid autoimmunity and Menière's disease

Anti-68 kDa antibodies in autoimmune sensorineural hearing loss

The autoimmune characteristics of progressive or sudden sensorineural hearing loss

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