Antiphospholipid syndrome: interpretation of laboratory data

Pengo, Vittorio

doi:10.1111/j.1538-7836.2010.04151.x

Cited by 15 publications

(14 citation statements)

References 20 publications

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“…It was reported that patients positive in all three assays included in the latest classification criteria (LA, aCL, aβ2GPI) have a better correlation with clinical symptoms of APS [19]. In agreement with the abovementioned studies, in our analyzed patients, RPL and VTs were associated with multiple positivity for aPL Abs and aanxA5 Abs of the IgM isotype (Table 4).…”

Section: Discussionsupporting

confidence: 93%

The IgM isotype of anti-annexin A5 antibodies and multiple positivity of conventional antiphospholipid antibodies: increasing the number of clinical manifestations of primary antiphospholipid syndrome

et al. 2016

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We evaluated the importance of anti-annexin A5 antibodies (aanxA5 Abs) for clinical (thrombosis and/or recurrent pregnancy loss) and serologic (presence of antiphospholipid antibodies: lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2 glycoprotein I (aβ2GPI) antibodies) features of patients with primary antiphospholipid syndrome (PAPS). Our study included 70 patients with PAPS according to the international consensus criteria for APS. The mean age of the analyzed patients was 45.97 ± 12.72. The disease duration above 5 years was present in 31/70 of patients. Concentrations of analyzed antibodies were measured by ELISA. Cutoff values were set in accordance to the manufacturers' recommendations. History of recurrent pregnancy loss was associated with double positivity for aanxA5 IgM and LA (χ (2) = 4.000, P = 0.046) and triple positivity for aanxA5 IgM + LA + aβ2GPI IgM (χ (2) = 4.168, P = 0.041). Venous thromboses were associated with triple positivity for aanxA5 IgM + aCLIgG + aβ2GPI IgM (χ (2) = 3.965, P = 0.046). The IgG isotype of aanxA5 Abs was in positive correlation with aCL Abs of the IgG (r = 0.310, P = 0.009) and IgM (r = 0.254, P = 0.034) isotype. The presence of the clinical manifestations of PAPS is increasing with the number of positive conventional aPL and the IgM aanxA5 Abs tests. This new combination of Abs is beneficial even when the number of patients with positivity for aanxA5 Abs is low. This is important in further detection of patients prone to recurrence of thrombotic episodes.

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Section: Discussionsupporting

confidence: 93%

The IgM isotype of anti-annexin A5 antibodies and multiple positivity of conventional antiphospholipid antibodies: increasing the number of clinical manifestations of primary antiphospholipid syndrome

et al. 2016

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“…All positive assays were IgM assays. Taking recent debate of single positivity and the value of a positive IgM assay into account, one could doubt the clinical value of this APS diagnosis . Patient 6 was negative by all assays on Zenit, positive for aβ2GPI IgM with ELISA and Acustar.…”

Section: Resultsmentioning

confidence: 98%

Performance of two new, automated chemiluminescence assay panels for anticardiolipin and anti‐beta2‐glycoprotein I antibodies in the laboratory diagnosis of the antiphospholipid syndrome

Hoecke

Persijn

Decavele

et al. 2012

Int J Lab Hematology

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“…It is important to note that confirmatory repeat testing is required 12 weeks from the original testing date [17 && ]. Triple test positivity (lupus anticoagulant positive, IgM/IgG aCL >40GPL, and IgM/IgG ab2-GPI >99th percentile) has been linked with higher rates of thrombotic events, which is useful for risk stratification in APS patients [2].…”

Section: Screeningmentioning

confidence: 99%