Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice

Ganoderma terpenoid extract exhibited anti-plasmodial activity by a mechanism involving reduction in erythrocyte and hepatic lipids in Plasmodium berghei infected mice

“…In Nigeria and her neighboring West African states, mushroom are consumed for their nutritional benefit rather than for their medicinal values. The component parts of this mushroom including the mycelium, fruit bodies and spores have been demonstrated to exhibit different bioactive properties including antioxidant [15], antitumor [9], anti-inflammatory [10], antidiabetic [31], antimicrobial and antimalarial [12–14] activities, and they are currently being deployed in the management of diseases such as cancer hypertension), immunosuppression and hypercholesterolemia [32]. Based on the positive attributes of mushroom consumption on animal nutrition and health, increase awareness on the inclusion of mushroom in our daily meal is warranted.…”

“…Ganoderma lucidum is an edible mushroom with long history of use as a medicinal herb in Oriental countries [7]. The extract has been investigated for its health benefits in preventing cardiovascular disease, cancer, and microbial infection, and for its lipid and glucose lowering, anti-inflammation, anti-oxidant, anti-parasite, and multiple organ protection effects [8–15]. Its long history of usage with no attendant toxicity represents the desired end result in the development of effective therapeutic interventions.…”

“…Terpenoids extracted from Ganoderma lucidum have been demonstrated to exhibit anti-hypertensive [8], hypocholesterolemic [10, 11], hepatoprotective [12], and cytotoxicity against numerous cancer cell lines [13]. A recent study by Oluba et al [15] demonstrated the promising potential of crude chloroform extract of Ganoderma lucidum fruit body as an anti-plasmodial agent.…”