Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat fever in human body and veterinary medicine such as drugs, aspirin, ibuprofen, naproxen and paracetamol. NSAIDs are a class of drugs that provides antipyretic effects that is used for fever-reducing agent. Fever is normal condition that is faced by human body when the blood temperature rises and the heat production in the body increasing and cause human body weak, fatigue, and headache, warmth, sweating and feeling cold. However, synthetic drugs have dangerous side effect towards human body if over dosages. Thus, herbal medicine is found out as an alternative way that can be used to treat fever and relief pain. Some researcher found that AquilariaSubintegra Spp. contains antipyretic properties that can reduce fever. The aim for this study is to determine the n-hexane extractionof antipyretic properties from planted AquilarisSubintegra Spp. dried leaves by using conventional oven. The antipyretics properties are obtained in different drying temperature 40, 50 and 60°C. As the drying temperature increase, the retention time will be reduced and the presences of antipyretic properties can be detected.