Antiplasmodial and other constituents from four Indonesian Garcinia spp.

Elfita, Elfita; Muharni, Muharni; Latief, Madyawati; Darwati, Darwati; Widiyantoro, Ari; Supriyatna, Supriyatna; Bahti, Husein H.; Dachriyanus, Dachriyanus; Cos, Paul; Maes, Louis

doi:10.1016/j.phytochem.2009.04.024

Cited by 65 publications

(58 citation statements)

References 37 publications

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“…By combining the results obtained by the spectrometric methods (IR, 1 H-NMR, 13 C-NMR, HMQC, HMBC and COSY) was proposed C 18 H 20 O 6 as the molecular formula for compound 1, The molecular formula indicated nine degrees of unsaturation. The NMR spectrums for 1 revealed that seven of the nine unsaturation degrees were attributed to one carbonyl, and five double bond.…”

Section: Resultsmentioning

confidence: 99%

“…Based on NMR spectroscopic analysis including IR, 1 H-NMR, 13 C-NMR, HMQC, HMBC and COSY, the compounds is 8,10,12-trihydroxy-9-methoxy-7a-methyl-7,7a,12a,13-tetrahydrobenzocycloheptaoxocin-6-one.…”

Section: Resultsmentioning

confidence: 99%

“…Other than that has been isolated two steroid glucoside β-sitosterol-3-O-β-Dglucoside and stigmasterol-3-O-β-D-glucoside [10][11][12][13][14].…”

Section: Short Communicationmentioning

confidence: 99%

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SECONDARY METABOLITE FROM ENDOPHYTIC FUNGI Aspergillus niger OF THE STEM BARK OF KANDIS GAJAH (Garcinia griffithii)

Elfita¹,

Muharni²,

Munawar³

et al. 2012

Indones. J. Chem.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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SECONDARY METABOLITE FROM ENDOPHYTIC FUNGI Aspergillus niger OF THE STEM BARK OF KANDIS GAJAH (Garcinia griffithii)

Elfita¹,

Muharni²,

Munawar³

et al. 2012

Indones. J. Chem.

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“…Tinaspora crispa (locally named "brotowali" in Indonesia) has been used by traditional folklore for antimalarial, antifilarial, and antipyretic [4][5]. Its stem has been used for various therapeutic purposes such as treatment for diabetes, hypertension, stimulation of appetite and protection from mosquito bites [6].…”

Section: Introductionmentioning

confidence: 99%

“…In our search for secondary metabolites of endophytic fungi, many bioactive and/or new compounds were isolated [4,[9][10][11]. Elfita et al [4] was reported the isolation of eight endophytic fungi from the stems and leaves of brotowali, but the fungus Fusarium sp.…”

Section: Introductionmentioning

confidence: 99%

NEW PYRAN OF AN ENDOPHYTIC FUNGUS Fusarium sp. ISOLATED FROM THE LEAVES OF BROTOWALI (Tinaspora crispa)

Elfita¹,

Munawar²,

Muharni³

et al. 2013

Indones. J. Chem.

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Complete NMR assignments of bioactive rotameric (3 → 8) biflavonoids from the bark of Garcinia hombroniana

Jamila

Khairuddean

Khan

et al. 2014

Magnetic Reson in Chemistry

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The genus Garcinia is reported to possess antimicrobial, anti-inflammatory, anticancer, hepatoprotective and anti-HIV activities. Garcinia hombroniana in Malaysia is used to treat itching and as a protective medicine after child birth. This study was aimed to isolate the chemical constituents from the bark of G. hombroniana and explore their possible pharmacological potential. Ethyl acetate extract afforded one new (1) and six (2-7) known 3 → 8 rotameric biflavonoids. Their structures were elucidated by UV, IR and NMR (1D and 2D) spectroscopy together with electron ionization/ESI mass spectrometric techniques and were identified as (2R, 3S) volkensiflavone-7-O-rhamnopyranoside (1), volkensiflavone (2), 4″-O-methyl-volkensiflavone (3), volkensiflavone-7-O-glucopyranoside (4), morelloflavone (5), 3″-O-methyl-morelloflavone (6) and morelloflavone-7-O-glucopyranoside (7). The absolute configuration of compound 1 was assigned by circular dichroism spectroscopy as 2R, 3S. The coexistence of conformers of isolated biflavonoids in solution at 25 °C in different solvents was confirmed by variable temperature NMR studies. At room temperature (25 °C), compounds 1-7 exhibited duplicate NMR signals, while at elevated temperature (90 °C), a single set of signals was obtained. Compound 5 showed significant in vitro antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl and 2,2'-azino-bis-3-ethyl benzthiazoline-6-sulfonic acid radicals. The antibacterial studies showed that compounds 5 and 6 are the most active against Staphylococcus aureus, Bacillus subtilis and Escherichia coli. Compounds 3 and 6 also showed moderate antituberculosis activity against H38 Rv. Based on the research findings, G. hombroniana could be concluded as a rich source of flavanone-flavone (3 → 8) biflavonoids that exhibit rotameric behaviour at room temperature and display significant antioxidant and antibacterial activities.

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Antiplasmodial and other constituents from four Indonesian Garcinia spp.

Cited by 65 publications

References 37 publications

SECONDARY METABOLITE FROM ENDOPHYTIC FUNGI <i>Aspergillus niger</i> OF THE STEM BARK OF KANDIS GAJAH (<i>Garcinia griffithii</i>)

SECONDARY METABOLITE FROM ENDOPHYTIC FUNGI <i>Aspergillus niger</i> OF THE STEM BARK OF KANDIS GAJAH (<i>Garcinia griffithii</i>)

NEW PYRAN OF AN ENDOPHYTIC FUNGUS <i>Fusarium</i> sp. ISOLATED FROM THE LEAVES OF BROTOWALI (<i>Tinaspora crispa</i>)

Complete NMR assignments of bioactive rotameric (3 → 8) biflavonoids from the bark of Garcinia hombroniana

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