Antiplasmodial, anti-complement and anti-inflammatory in vitro effects of Biophytum umbraculum Welw. traditionally used against cerebral malaria in Mali

Austarheim, Ingvild; Pham, Anh Thu; Nguyen, Chi Mai; Zou, Yuanfeng; Diallo, Drissa; Malterud, Karl Egil; Wangensteen, Helle

doi:10.1016/j.jep.2016.05.058

Cited by 10 publications

(8 citation statements)

References 27 publications

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“…The plant where it was first found, C. occidentalis , is a known antimalarial plant and is used in Mali as one of the components of the “Improved Traditional Medicine” Malarial [33], which has been subjected to clinical studies. In view of the traditional use in Mali against cerebral malaria and the related chemistry between B. umbraculum and C. occidentalis , we investigated the malaria-related and antiinflammatory properties of B. umbraculum extracts and pure substances [34]. The ethyl acetate extract showed antiplasmodial, anti-complement and antiinflammatory activity and inhibited lipopolysaccharide stimulation in macrophages, but this appears to be due to other constituents than the isolated flavonoids.…”

Section: Biophytum Umbraculummentioning

confidence: 99%

Ethnopharmacology, Chemistry and Biological Properties of Four Malian Medicinal Plants

Malterud

2017

Plants

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The ethnopharmacology, chemistry and pharmacology of four Malian medicinal plants, Biophytum umbraculum, Burkea africana, Lannea velutina and Terminalia macroptera are reviewed. These plants are used by traditional healers against numerous ailments: malaria, gastrointestinal diseases, wounds, sexually transmitted diseases, insect bites and snake bites, etc. The scientific evidence for these uses is, however, limited. From the chemical and pharmacological evidence presented here, it seems possible that the use in traditional medicine of these plants may have a rational basis, although more clinical studies are needed.

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Section: Biophytum Umbraculummentioning

confidence: 99%

Ethnopharmacology, Chemistry and Biological Properties of Four Malian Medicinal Plants

Malterud

2017

Plants

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“…The probable presence of the species of cyclocolorenone, a compound with an α, β unsaturated cyclopentenone ring (a reactive structural element similar to sesquiterpene lactones), and stigmasterol, a phytosterol that inhibits some pro-inflammatory and pro-degradative mediators involved in inflammation, may contribute to or produce the anti-inflammatory effect observed. Africa The annual herb Biophytum umbraculum (Oxalidaceae), which is commonly found in tropical and subtropical Africa and Asia, is a highly valued medicinal plant used to treat hemorrhoids, wounds, stomach aches, fevers [ 58 ], dysregulated inflammation, conjunctivitis, vaginitis and colon illnesses, among others [ 59 ]. In Mali, the aerial parts are used to treat both children and adults, and no toxicity has been reported.…”

Section: Resultsmentioning

confidence: 99%

“…In Mali, the aerial parts are used to treat both children and adults, and no toxicity has been reported. The most common way to prepare and administer the medicine is to mix the powder of the flowering aerial parts with water; it can be applied topically, massaging to facilitate the transdermal bioavailability of the compounds, or it can be taken orally [ 59 ]. Cassiaoccidentalin A, isovitexin, and isoorientin are flavone-C-glycosides that are isolated from the EtOAc-soluble fraction of the methanol crude extract [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

Solving the puzzle: what is behind our forefathers anti-inflammatory remedies?

Villanueva

Alonso‐Esteban

Villanueva

2017

J Intercult Ethnopharmacol

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Inflammation is a ubiquitous host response in charge of restoring normal tissue structure and function but is a double-edged sword, as the uncontrolled or excessive process can lead to the injury of host cells, chronic inflammation, chronic diseases, and also neoplastic transformation. Throughout history, a wide range of species has been claimed to have anti-inflammatory effects worldwide. Among them, Angelica sinensis, Tropaeolum majus, Castilleja tenuiflora, Biophytum umbraculum, to name just a few, have attracted the scientific and general public attention in the last years. Efforts have been made to assess their relevance through a scientific method. However, inflammation is a complex interdependent process, and phytomedicines are complex mixtures of compounds with multiple mechanisms of biological actions, which restricts systematic explanation. For this purpose, the omics techniques could prove extremely useful. They provide tools for interpreting and integrating results from both the classical medical tradition and modern science. As a result, the concept of network pharmacology applied to phytomedicines emerged. All of this is a step toward personalized therapy.

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“…Some earlier studies supported the proposition that the production of nitric oxide by macrophages plays a crucial role in the control of parasitaemia at the initial periods of blood stage malarial infection (Awasthi et al, 2003). However, the ethyl acetate extract of B. umbraculum which revealed in vitro antiplasmodial effect, but gave an inhibition of macrophage activation (Austarheim et al, 2016).…”

Section: Measurement Of Nitrite Oxide (No) Released From Stimulated Mmentioning

confidence: 95%

“…It has also been shown that the ethyl acetate extract of Biophytum umbraculum (syn. B. petersianum) showed in vitro antiplasmodial effect and also an effect in the complement assay (Austarheim et al, 2016). Glucans are often recognized by their immunostimulatory activity and complement receptor type 3 (CR3, also CD11b/CD18) is a prime candidate as β-Dglucan receptor on human monocytes, neutrophils and NK cells (also dectin-1) according to Vannucci et al (2013).…”

Section: Complement Fixation Activitymentioning

confidence: 99%

Immunomodulatory activities of polysaccharides isolated from plants used as antimalarial in Mali

Dénou¹,

Togola²,

Inngjerdingen³

et al. 2019

J. Pharmacognosy Phytother.

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Medicinal plants used against malaria in Mali have previously been tested for their antiplasmodial activities using their organic solvent and water extracts. As the healers mainly use the water extracts for their treatments of malaria-patients, our aim was to study the water-soluble components from Malian plants used for treatment of malaria. Argemone mexicana (aerial parts), Sarcocephalus latifolius (root bark), Vitex doniana (leaves), and Malarial-5 ® (an improved traditional medicine (ITM) in tea) were the objects of our studies. Water extracts of these plants contained primarily polysaccharides. Due to this, the studies focused on the determination of the monosaccharide composition of the polymers present as well as assessing the immunomodulatory properties of the polysaccharide fractions isolated from these plants. Each plant material was extracted sequentially with dichloromethane, 80% ethanol and water at 100°C. The polysaccharides were obtained using gel filtration of the aqueous extracts and their monosaccharide compositions were determined using gas chromatography. Immunomodulatory effects were assessed using the complement fixation test and macrophage stimulation. All aqueous extracts from the four samples contained polysaccharides. The monosaccharide compositions vary between the plants. Arabinose, rhamnose, galactose, glucose and galacturonic acid were present in all samples, glucose being the main monomer. These polysaccharides showed complement fixing activity and induced nitrite oxide release from macrophages in a dose dependent manner. The polysaccharide fractions of A. mexicana (Am1) and V. doniana (Vd1) showed the most potent activities. These two fractions had an ICH 50 of 2.4 and 6.3 μg/mL respectively in the complement fixation assay. The same two fractions induced a dose dependent release of nitrite oxide from macrophages. The results demonstrated that antimalarial plants contain polysaccharides with immunomodulatory properties. This preliminary work constitutes a new approach of antimalarial studies.

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Antiplasmodial, anti-complement and anti-inflammatory in vitro effects of Biophytum umbraculum Welw. traditionally used against cerebral malaria in Mali

Cited by 10 publications

References 27 publications

Ethnopharmacology, Chemistry and Biological Properties of Four Malian Medicinal Plants

Ethnopharmacology, Chemistry and Biological Properties of Four Malian Medicinal Plants

Solving the puzzle: what is behind our forefathers anti-inflammatory remedies?

Immunomodulatory activities of polysaccharides isolated from plants used as antimalarial in Mali

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Antiplasmodial, anti-complement and anti-inflammatory in vitro effects of Biophytum umbraculum Welw. traditionally used against cerebral malaria in Mali

Cited by 10 publications

References 27 publications

Ethnopharmacology, Chemistry and Biological Properties of Four Malian Medicinal Plants

Ethnopharmacology, Chemistry and Biological Properties of Four Malian Medicinal Plants

Solving the puzzle: what is behind our forefathers&#146; anti-inflammatory remedies?

Immunomodulatory activities of polysaccharides isolated from plants used as antimalarial in Mali

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Product

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Solving the puzzle: what is behind our forefathers anti-inflammatory remedies?