Antiplasmodial Constituents from the Fruit Pericarp of<i>Pentadesma butyracea</i>

Lenta, Bruno Ndjakou; Kamdem, Louis Marie; Ngouela, Silvère; Tantangmo, Ferdinand; Devkota, Krishna Prasad; Boyom, Fabrice Fekam; Rosenthal, Philip John; Tsamo, Etienne

doi:10.1055/s-0030-1250384

Cited by 14 publications

(15 citation statements)

References 13 publications

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“…The structural similarity of compound 14 with 15, 16, and 17 indicates that the substitution patterns on both the A and B rings influence the antiplasmodial activity of the compound. The lack of an isoprenyl chain at C-8 on 14, when compared with 15, 16, and 17, suggests the importance of this isoprenyl group and is supported by a previous study on prenylated xanthones from Pentadesma butyracea (Clusiaceae) [23]. While both 15 and 17 showed activities against the D6 and W2 clones, 17 with the cyclization between C-2 and C-3 had a lower IC 50 against both clones.…”

supporting

confidence: 59%

“…Neither 15 nor 16 have been previously screened against the P. falciparum clone D6, and this is the first report of antimalarial activity for 17. Previous studies have shown 15 to be active against various nonresistant and drug-resistant clones of P. falciparum[13,21] and compound 16 against the drug-resistant P. falciparum clones K 1 and W2[22,23]. -dione benzophenone skeleton and various side chains were examined.…”

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confidence: 99%

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In Vitro Antiplasmodial Activity of Benzophenones and Xanthones from Edible Fruits of Garcinia Species

et al. 2014

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Species of Garcinia have been used to combat malaria in traditional African and Asian medicines, including Ayurveda. In the current study, we have identified antiplasmodial benzophenone and xanthone compounds from edible Garcinia species by testing for in vitro inhibitory activity against Plasmodium falciparum. Whole fruits of Garcinia xanthochymus, G. mangostana, G. spicata, and G. livingstonei were extracted and tested for antiplasmodial activity. Garcinia xanthochymus was subjected to bioactivity-guided fractionation to identify active partitions. Purified benzophenones (1-9) and xanthones (10-18) were then screened in the plasmodial lactate dehydrogenase assay and tested for cytotoxicity against mammalian (Vero) cells. The benzophenones guttiferone E (4), isoxanthochymol (5), and guttiferone H (6), isolated from G. xanthochymus, and the xanthones α-mangostin (15), β-mangostin (16), and 3-isomangostin (17), known from G. mangostana, showed antiplasmodial activity with IC50 values in the range of 4.71-11.40 µM. Artemisinin and chloroquine were used as positive controls and exhibited IC50 values in the range of 0.01-0.24 µM. The identification of antiplasmodial benzophenone and xanthone compounds from G. xanthochymus and G. mangostana provides evidence for the antiplasmodial activity of Garcinia species and warrants further investigation of these fruits as dietary sources of chemopreventive compounds.

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supporting

confidence: 59%

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confidence: 99%

In Vitro Antiplasmodial Activity of Benzophenones and Xanthones from Edible Fruits of Garcinia Species

et al. 2014

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“…with respective IC 50 values of 3.53, 1.29 and 3.17 μM, for gaboxanthone ( 84 ), symphonin ( 85 ) and globuliferin ( 86 ) [92]. Bioassay-guided fractionation of the fruit pericarp of Pentadesma butyracea , using the antiplasmodial test, led to the isolation of a new bioactive xanthone, named pentadexanthone ( 87 ) (IC 50 = 3 μM against W2), together with three known compounds: cratoxylone ( 88 ) (IC 50 = 2.89 μM), α-mangostin (89) (IC 50 = 2.77 μM), and garcinone E (90) (IC 50 = 0.41 μM) [93]. …”

Section: Introductionmentioning

confidence: 99%

The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids

Ntie‐Kang

Onguéné

Lifongo

et al. 2014

Malar J

115

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Malaria is currently a public health concern in many countries in the world due to various factors which are not yet under check. Drug discovery projects targeting malaria often resort to natural sources in the search for lead compounds. A survey of the literature has led to a summary of the major findings regarding plant-derived compounds from African flora, which have shown anti-malarial/antiplasmodial activities, tested by in vitro and in vivo assays. Considerations have been given to compounds with activities ranging from “very active” to “weakly active”, leading to >500 chemical structures, mainly alkaloids, terpenoids, flavonoids, coumarins, phenolics, polyacetylenes, xanthones, quinones, steroids and lignans. However, only the compounds that showed anti-malarial activity, from “very active” to “moderately active”, are discussed in this review.

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“…Rumex bequaertii has a good biologic potential, having been tested as possible antiviral agent [10], while the Pentadesma butyracea fruit extracts have cytotoxic and antimalarial activities [11] due especially to cratoxylone, α-mangostin, 1,3,5-trihydroxy-2-methoxyxanthone, garcinone E, epicathechin and lupeol [12].…”

Section: Introductionmentioning

confidence: 99%

Anticancer and Antimicrobial Activities of Some Antioxidant-Rich Cameroonian Medicinal Plants

et al. 2013

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Traditional remedies have a long-standing history in Cameroon and continue to provide useful and applicable tools for treating ailments. Here, the anticancer, antimicrobial and antioxidant activities of ten antioxidant-rich Cameroonian medicinal plants and of some of their isolated compounds are evaluated.The plant extracts were prepared by maceration in organic solvents. Fractionation of plant extract was performed by column chromatography and the structures of isolated compounds (emodin, 3-geranyloxyemodin, 2-geranylemodin) were confirmed spectroscopically. The antioxidant activity (AOA) was determined using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) bleaching method, the trolox equivalent antioxidant capacity (TEAC), and the hemoglobin ascorbate peroxidase activity inhibition (HAPX) assays. The anticancer activity was evaluated against A431 squamous epidermal carcinoma, WM35 melanoma, A2780 ovary carcinoma and cisplatin-resistant A2780cis cells, using a direct colorimetric assay. The total phenolic content in the extracts was determined spectrophotometrically by the Folin–Ciocalteu method. Rumex abyssinicus showed the best AOA among the three assays employed. The AOA of emodin was significantly higher than that of 3-geranyloxyemodin and 2-geranylemodin for both TEAC and HAPX methods. The lowest IC50 values (i.e., highest cytotoxicity) were found for the extracts of Vismia laurentii, Psorospermum febrifugum, Pentadesma butyracea and Ficus asperifolia. The Ficus asperifolia and Psorospermum febrifugum extracts are selective against A2780cis ovary cells, a cell line which is resistant to the standard anticancer drug cisplatin. Emodin is more toxic compared to the whole extract, 3-geranyloxyemodin and 2-geranylemodin. Its selectivity against the platinum-resistant A2780cis cell line is highest. All of the extracts display antimicrobial activity, in some cases comparable to that of gentamycin.

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Antiplasmodial Constituents from the Fruit Pericarp ofPentadesma butyracea

Cited by 14 publications

References 13 publications

In Vitro Antiplasmodial Activity of Benzophenones and Xanthones from Edible Fruits of Garcinia Species

In Vitro Antiplasmodial Activity of Benzophenones and Xanthones from Edible Fruits of Garcinia Species

The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids

Anticancer and Antimicrobial Activities of Some Antioxidant-Rich Cameroonian Medicinal Plants

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