Antiplasmodial potential of the African mistletoe: Agelanthus dodoneifolius Polh and Wiens

Builders, Modupe Iretiola; Uguru, M. O.; Aguiyi, C. John

doi:10.4103/0250-474x.106064

Cited by 19 publications

(23 citation statements)

References 23 publications

(16 reference statements)

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“…This suggests that the plant's antimalarial property can be rated as being moderate. Similar reports have rated other plants having antimalarial potential based on this scale [48,49]. Languas galangal and Agelanthus dodeneifolius have been shown to have similar suppressive action as M. barteri [50].…”

Section: Resultssupporting

confidence: 64%

Antimalarial Activity of Ethanolic Leaf Extract of Maesobotrya barteri and Effects on Some Hematological and Biochemical Parameters of Mice

Peters

Ezendiokwere

Njoku

et al. 2017

JALSI

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Aim: This study was conducted to determine the antimalarial activity of ethanolic leaf extract of Maesobotrya barteri, and effects on some hematological and biochemical parameters. Methodology: Twenty eight albino mice were selected and twenty four of these were injected intraperitoneally with 1×10 6 Plasmodium berghei (NK65 strain) parasitized red blood cells in 0.5 ml of distilled water on the first day. After 72 hours, the animals were placed in seven groups having four animals each. Group 1 was uninoculated and untreated. Group 2 (inoculated and untreated) served as negative control. Group 3 was treated with 25 mg/kg bwt chloroquine and served as the positive control. Group 4 was treated with 4 mg/kg body weight of artesunate. 500 mg/kg, 800 mg/kg and 1000 mg/kg body weight of the extract were administered to groups 5, 6 and 7 respectively for four (4) days. On the fifth day post administration, the animals were anesthesized and blood obtained by cardiac puncture for hematological and biochemical investigation. The liver from the mice were harvested after sacrifice on the fifth day and subjected to histological Original Research Article

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Section: Resultssupporting

confidence: 64%

Antimalarial Activity of Ethanolic Leaf Extract of Maesobotrya barteri and Effects on Some Hematological and Biochemical Parameters of Mice

Peters

Ezendiokwere

Njoku

et al. 2017

JALSI

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show abstract

“…non-primate animal models. Therefore, for the in vivo evaluation of antimalarial activities in rodents, the rodent malaria parasite is employed, due to the sensitivity of P. berghei ANKA parasite to CQ [15]. The repository test was used to study the prophylactic activity, while Peter's 4-day suppressive test was used to evaluate schizontocidal activity.…”

Section: Discussionmentioning

confidence: 99%

Antimalarial Activity of Ethanolic Leaf Extract of Bauhinia strychnifolia in Mice Infected with Plasmodium berghei

Somsak¹,

Noilod²

2015

Malaria Contr Elimination

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The emerging resistance of Plasmodium species to currently available antimalarial drugs remains a public health problem, hence the need for new effective, safe and affordable drugs. Plant extracts remain a reliable source of drugs. Bauhinia strychnifolia (Yha-nang dang) is widely distributed and has been traditionally used in Thailand to treat fever, alcoholic toxication and allergy. The leaf extract of B. strychnifolia had potent antioxidant, anti-cancer and anti-microbial activities. The aim of the study was at investigating antimalarial activities of B. strychnifolia in malaria infected rodent models. Acute toxicity of ethanolic crude extract of B. strychnifolia leaves was assessed in mice up to a dose of 6,000 mg/kg. ICR mice were inoculated with Plasmodium berghei ANKA and treated with the extracts (500, 1500 and 3000 mg/kg) orally by gavage. Four day suppressive and curative effect against established infection and prophylactic models of antimalarial studies were carried out. The extract did not show any toxic effect because doses up to 3,000 mg/kg caused no death or alter the behavior of the tested normal mice. For antimalarial studies, the extract (3,000 mg/kg) exerted significant (P < 0.01) effects of prophylactic, suppressive, and curative with percent inhibition of 59%, 84%, and 68%, respectively. However, antimalarial effect of chloroquine at 5 mg/kg was higher than the extract in all test models. These results indicate that ethanolic crude extract of B. strychnifolia leaves has excellent in vivo antimalarial activities against P. berghei ANKA. Hence, this plant extract represents a promising source of new antimalarial agents.

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“…Non-primate animal models are not infected by Plasmodium species that cause human disease. As a result, the rodent malaria parasite called P. berghei, which is sensitive to CQ, is employed for in vivo evaluation of antimalarial activities in rodents (27). Three recommended methods were employed to determine the most important parameter, parasitaemia inhibition rate, including the Peter's 4-day suppressive test, Rane's test, employed to investigate curative effect in already established infection, and the repository test for prophylactic activity test.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of In vivo Antimalarial Activities of leaves of Moringa oleifera against Plasmodium berghei in Mice

Mulisa

Girma

Tesema

et al. 2018

Jundishapur J Nat Pharm Prod

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Background: In addition to resistance against drugs, no new drugs have reached the market during the last decade for malaria treatment. This implies the urgent need to search for new drugs from different sources. Medicinal plants are one of such sources for novel drugs. Therefore, the aim of the current study was to investigate antimalarial activity of crude extract of leaves of Moringa oleifera Lam (Moringaceae) in Plasmodium berghei in a mice model. Methods:The acute toxicity test was used as per standard guidelines. To determine parasite inhibition, 4-day Peter's suppressive test was done. Curative and prophylactic tests were done by applying standard methods. Windows SPSS version 16 was used to analyse the data and analysis of variance (ANOVA) followed by Post Hoc Tukey's HSD to compare results between groups. Results: Death was not observed up to a dose of 2000 mg/kg of the plant extract. In all mice treated with the extract, the level of parasitaemia was significantly reduced in comparison with the control group (P < 0.001) and also a very significant difference was observed in comparison with the chloroquine treated group (P < 0.0001) with lower doses. Mean survival time was significantly increased at all treatment doses. It reduced parasitemia in a dose-dependent manner in both curative and prophylactic activity tests resulting in a significant (P < 0.05) reduction of parasitaemia in comparison with the control group. Conclusions:The result of the current study revealed that the extract possessed significant anti-plasmodial activity as displayed by its ability to suppress P. berghei infection in mice. The present study can be considered as confirmation for traditionally claimed use of the plant against malaria treatment.

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Antiplasmodial potential of the African mistletoe: Agelanthus dodoneifolius Polh and Wiens

Cited by 19 publications

References 23 publications

Antimalarial Activity of Ethanolic Leaf Extract of Maesobotrya barteri and Effects on Some Hematological and Biochemical Parameters of Mice

Antimalarial Activity of Ethanolic Leaf Extract of Maesobotrya barteri and Effects on Some Hematological and Biochemical Parameters of Mice

Antimalarial Activity of Ethanolic Leaf Extract of Bauhinia strychnifolia in Mice Infected with Plasmodium berghei

Evaluation of In vivo Antimalarial Activities of leaves of Moringa oleifera against Plasmodium berghei in Mice

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