Antiplasmodial prenylated flavanonols from <i>Tephrosia subtriflora</i>

Muiva-Mutisya, Lois; Atilaw, Yoseph; Heydenreich, Matthias; Koch, Andreas; Akala, Hoseah M.; Cheruiyot, Agnes C.; Brown, Matthew L.; Irungu, Beatrice; Okalebo, Faith A.; Derese, Solomon; Mutai, Charles; Yenesew, Abiy

doi:10.1080/14786419.2017.1353510

Cited by 15 publications

(8 citation statements)

References 17 publications

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“…purpurea, the aerial parts of T. subtriflora, and isolated flavonoids showed in vitro chemo-suppressive effect against the CQ-sensitive strains of P. falciparum (D6) [32,33]. Conversely, in this study, the ethanolic root extract of T. gracilipes was inactive (IC 50 >200 µg/mL), which could be due to…”

Section: Discussioncontrasting

confidence: 49%

In vitro antimalarial activity of selected medicinal plants native to Tigray region of Ethiopia

Tekulu¹,

D’Alessandro²,

Parapini³

et al. 2019

Preprint

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BackgroundVarious medicinal plants are used as alternative remedies for the management of malaria, an important infectious disease responsible for around 228 million cases and 405,000 deaths worldwide in 2018. The worsening of the disease is highly associated to an emergence of drug-resistant parasites. Hence, the search of new alternative antimalarial agents from traditionally used medicinal plants is the most viable approach. The current study was aimed to evaluate the in vitro antiplasmodial property of Aloe elegans, Aloe monticola, Capparis tomentosa, Hygrophila schulli and Tephrosia gracilipes extracts.Methods Leaf latexes were collected from Aloe elegans and Aloe monticola, whereas cold maceration with 70% ethanol was used to prepare extracts from roots of Capparis tomentosa and Tephrosia gracilipes , and leaves of Hygrophila schulli . The antiplasmodial activity of the extracts against asexual and gametocyte stages was tested using parasite lactate dehydrogenase assay and luciferase assay, respectively. Cell cytotoxicity was assessed on human microvascular endothelial cells by the MTT assayResults Of the five selected medicinal plants, leaf latex of Aloe monticola showed the best activity against both asexual stages and stage V gametocytes of Plasmodium falciparum . The leaf latex of Aloe elegans and ethanolic extract of Hygrophila schulli leaves also showed antiplasmodial property against asexual stages. On the contrary, the roots of Capparis tomentosa and Tephrosa gracilipes were inactive.Conclusion Findings of this study may partly support the acclaimed traditional use of the leaves latexes of both Aloe elegans and Aloe monticola and the ethanolic extract of Hygrophila schulli leaves for the management of mild to moderate malaria.

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Section: Discussioncontrasting

confidence: 49%

In vitro antimalarial activity of selected medicinal plants native to Tigray region of Ethiopia

Tekulu¹,

D’Alessandro²,

Parapini³

et al. 2019

Preprint

View full text Add to dashboard Cite

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“…It was not cytotoxic to cancerous HepG2 cells at 100 µM while being moderately cytotoxic against non-cancerous human cells, indicating selectivity against D6 parasites [198]. The aerial parts of the related Tephrosia subtriflora were also active against P. falciparum 3D7, D6, and KSM 009 field isolate (IC 50 = 4.5–11.4 µg/mL [199]. The prenylated flavonoid MS-II ( 320 ) was subsequently isolated from the active extract and inhibited the 3D7, KSM 009, and artemisinin-sensitive F32-TEM strains.…”

Section: Polyphenolsmentioning

confidence: 99%

“…The prenylated flavonoid MS-II ( 320 ) was subsequently isolated from the active extract and inhibited the 3D7, KSM 009, and artemisinin-sensitive F32-TEM strains. The compound was not cytotoxic against Hep2 and Vero cells at 247.5 µM, suggesting a selective antiplasmodial activity [199]. Furthermore, the root extract of Tephrosia aequilata , which inhibited 3D7 P. falciparum by 100% at 10 µg/mL, produced the new aequichalcone C ( 321 ).…”

Section: Polyphenolsmentioning

confidence: 99%

Antiplasmodial natural products: an update

Tajuddeen

Heerden

2019

Malar J

127

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BackgroundMalaria remains a significant public health challenge in regions of the world where it is endemic. An unprecedented decline in malaria incidences was recorded during the last decade due to the availability of effective control interventions, such as the deployment of artemisinin-based combination therapy and insecticide-treated nets. However, according to the World Health Organization, malaria is staging a comeback, in part due to the development of drug resistance. Therefore, there is an urgent need to discover new anti-malarial drugs. This article reviews the literature on natural products with antiplasmodial activity that was reported between 2010 and 2017.MethodsRelevant literature was sourced by searching the major scientific databases, including Web of Science, ScienceDirect, Scopus, SciFinder, Pubmed, and Google Scholar, using appropriate keyword combinations.Results and DiscussionA total of 1524 compounds from 397 relevant references, assayed against at least one strain of Plasmodium, were reported in the period under review. Out of these, 39% were described as new natural products, and 29% of the compounds had IC50 ≤ 3.0 µM against at least one strain of Plasmodium. Several of these compounds have the potential to be developed into viable anti-malarial drugs. Also, some of these compounds could play a role in malaria eradication by targeting gametocytes. However, the research into natural products with potential for blocking the transmission of malaria is still in its infancy stage and needs to be vigorously pursued.

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“…Flavanonol MS-II (24) is a flavanolol with 2 (2,2-dimethylchromene) rings. In spite of having been solely tested on sensitive strains, it demonstrates a relevant variety in activity depending on the strain (see ▶ Table 3) [68]. Its selectivity toward the parasite is noteworthy, proposing that resistant strains should be tested in order to assess the compoundʼs potential.…”

Section: Flavonoidsmentioning

confidence: 99%

Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents

et al. 2020

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Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the Plasmodium sp., has a highly variable antigenicity, which accounts for the emergence and spread of resistance to all available treatments. In light of this rising problem, scientists have turned to naturally occurring compounds obtained from plants recurrently used in traditional medicine in endemic areas. Ethnopharmacological approaches seem to be helpful in selecting the most interesting plants for the search of new antiplasmodial and antimalarial molecules. However, this search for new antimalarials is complex and time-consuming and ultimately leads to a great number of interesting compounds with a lack of discussion of their characteristics. This review aims to examine the most promising antiplasmodial phenolic compounds (phenolic acids, flavonoids, xanthones, coumarins, lignans, among others) and derivatives isolated over the course of the last 28 y (1990 – 2018) and discuss their structure-activity relationships, mechanisms of action, toxicity, new perspectives they could add to the fight against malaria, and finally, the difficulties of transforming these potential compounds into new antimalarials.

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Antiplasmodial prenylated flavanonols from Tephrosia subtriflora

Cited by 15 publications

References 17 publications

In vitro antimalarial activity of selected medicinal plants native to Tigray region of Ethiopia

In vitro antimalarial activity of selected medicinal plants native to Tigray region of Ethiopia

Antiplasmodial natural products: an update

Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents

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