Antiplatelet adhesion behavior of hyperbranched poly(<scp>l</scp>‐lactide)s containing glutamic acid terminal groups

Jikei, Mitsutoshi; Kobayashi, Yuuki; Matsumoto, Kazuya; Hirokawa, Makoto; Ueki, Shigeharu

doi:10.1002/app.46910

Cited by 6 publications

(3 citation statements)

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“…Platelet adhesion tests were performed based on our previous study . Briefly, citrated venous blood was collected from healthy volunteers using Quick Eye partner tubes.…”

Section: Materials and Methodsmentioning

confidence: 99%

“…Platelet adhesion tests were performed based on our previous study. 43 Briefly, citrated venous blood was collected from healthy volunteers using Quick Eye partner tubes. Platelet-rich plasma and platelet-poor plasma were obtained by centrifugation at 900 rpm (150 g) and 3000 rpm (1670 g), respectively, at 4 °C for 10 min using a Kubota 5910 refrigerated centrifuge (Tokyo, Japan).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Synthesis and Antiplatelet Adhesion Behavior of a Poly(L-lactide-co-glycolide)–Poly(1,5-dioxepan-2-one) Multiblock Copolymer

et al. 2021

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Platelet adhesion and denaturation on artificial medical implants induce thrombus formation. In this study, bioabsorbable copolymers composed of poly(L-lactide-co-glycolide) (PLGA) and poly(1,5-dioxepan-2-one) (PDXO) were synthesized and evaluated for their antiplatelet adhesive properties. The PLGA−PXO multiblock copolymer (PLGA−PDXO MBC) and its random copolymer (PLGA−PDXO RC) showed effective antiplatelet adhesive properties, and the number of adhered platelets was similar to those adhered on poly(2-methoxyethylacrylate), a known antiplatelet adhesive polymer, although a large number of denatured platelets were observed on a PLGA−poly(εcaprolactone) multiblock copolymer (PLGA−PCL MBC). Using monoclonal antifibrinogen IgG antibodies, we also found that both αC and γ-chains, the binding sites of fibrinogen for platelets, were less exposed on the PLGA−PDXO MBC surface compared to PLGA−PCL MBC. Furthermore, free-standing films of PLGA− PDXO MBC were prepared by casting the polymer solution on glass plates and showed good tensile properties and slow hydrolytic degradation in phosphate-buffered saline (pH = 7.4). We expect that the unique properties of PLGA−PDXO MBC, i.e., antiplatelet adhesive behavior, good tensile strength, and hydrolytic degradation, will pave the way for the development of new bioabsorbable implanting materials suitable for application at blood-contacting sites.

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“…Platelet adhesion tests were performed based on our previous study . Briefly, citrated venous blood was collected from healthy volunteers using Quick Eye partner tubes.…”

Section: Materials and Methodsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

Synthesis and Antiplatelet Adhesion Behavior of a Poly(L-lactide-co-glycolide)–Poly(1,5-dioxepan-2-one) Multiblock Copolymer

et al. 2021

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“…The end-functionalization of polymers also causes significant changes to their adhesion and degradability, showing the great potential of this method for preparing coating materials and biosurfaces. , However, in many cases, modifying the end-groups is designed to control only the solubility of polymers without altering other characteristics of interest. This approach will be important for conjugated polymers to improve the processability of organic photovoltaics and light-emitting devices and to maximize the functionality of the designed polymers.…”

Section: End-functionalized Homopolymersmentioning

confidence: 99%

End-Group Chemistry and Junction Chemistry in Polymer Science: Past, Present, and Future

2020

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The current goal in functional polymeric material research is the preparation of polymers with high-fidelity nanoscale self-assembled structures and advanced functionality. Thus, recent research efforts have focused on linking chemistry for the development of tailor-made polymers with desired properties. The design of α- or ω-functionalized telechelic polymers with strongly associative interactions is connected to their unique supramolecular self-assembly behavior in homopolymers and blends. In addition, the end-group modification of block copolymers has shown to alter the polymer morphology radically, resulting in unprecedented property changes arising from confinement effects. This is fascinating because the content of terminal moieties is small compared to that of macromolecular polymer backbones. As an emerging theme in polymer designs and end-group chemistry, the controlled synthesis of polymers with complex architectures and functional linkages has been performed extensively in the past few decades. However, the effects of this linkage on the resultant polymer properties remain elusive and thus will be an important research topic in polymer science in the near future.

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Control of Polycondensation

Yokozawa

Ohta

2022

Macromolecular Engineering

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Polycondensation is an important method of polymerization that affords polymers containing functional groups and/or aromatic rings in the backbone, which serve as fibers, engineering plastics, electrical materials, and so on by virtue of their strong intermolecular forces. Most research had been centered on how to increase the molecular weight of polymers and how to synthesize a variety of condensation polymers. Lately, however, polycondensation has developed in many controlled ways. This article describes (i) stoichiometric‐imbalanced polycondensation, in which high‐molecular‐weight polymers are obtained even when one of the two monomers are used in excess, (s) sequence control of monomer units in the backbone, (ii) molecular weight and dispersity control in polycondensation which proceeds in chain‐growth polymerization manner like living polymerization to afford aromatic polyamides, π‐conjugated polymers, and so on, (iii) chain topology control for linear, cyclic, and hyperbranched polymers, and (iv) architectures containing condensation polymer such as block copolymer, star polymer, and graft copolymer from a combination of controlled polycondensation and another polymerization method.

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Antiplatelet adhesion behavior of hyperbranched poly(l‐lactide)s containing glutamic acid terminal groups

Cited by 6 publications

References 57 publications

Synthesis and Antiplatelet Adhesion Behavior of a Poly(L-lactide-co-glycolide)–Poly(1,5-dioxepan-2-one) Multiblock Copolymer

Synthesis and Antiplatelet Adhesion Behavior of a Poly(L-lactide-co-glycolide)–Poly(1,5-dioxepan-2-one) Multiblock Copolymer

End-Group Chemistry and Junction Chemistry in Polymer Science: Past, Present, and Future

Control of Polycondensation

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