Antiplatelet effects of acidamides isolated from the fruits of Piper longum L.

Park, B.-S.; Son, Dong-Ju; Park, Y.-H.; Kim, T.W.; Lee, Sung Eun

doi:10.1016/j.phymed.2007.06.011

Cited by 77 publications

(43 citation statements)

References 11 publications

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“…Extracts of P. longum have been demonstrated to exert various properties, such as immunomodulatory effects, as well as hepatoprotective and antiasthmatic activity (20). It has been reported that PLM inhibits platelet aggregation (21), atherosclerosis plaque formation (22), and tumor cell growth (23,24). Interestingly, a recent report indicates that PLM can selectively kill tumor cells through increasing ROS levels (25).…”

mentioning

confidence: 99%

Piperlongumine Suppresses Dendritic Cell Maturation by Reducing Production of Reactive Oxygen Species and Has Therapeutic Potential for Rheumatoid Arthritis

Xiao

Shi

Qiu

et al. 2016

The Journal of Immunology

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Piperlongumine (PLM) is a natural product from the plant Piper longum that inhibits platelet aggregation, atherosclerosis plaque formation, and tumor cell growth. It has potential value in immunomodulation and the management of autoimmune diseases. In this study, we investigated the role of PLM in regulating the differentiation and maturation of dendritic cells (DCs), a critical regulator of immune tolerance, and evaluated its clinical effects in a rheumatoid arthritis mouse model. We found that PLM treatment reduced LPS-induced murine bone marrow–derived DC maturation, characterized by reduced expression of CD80/86, secretion of MCP-1, IL-12p70, IL-6, TNFα, IFN-γ, and IL-23, and reduced alloproliferation of T cells; however, PLM does not affect cell differentiation. Furthermore, PLM reduced intracellular reactive oxygen species (ROS) production by DCs and inhibited the activation of p38, JNK, NF-κB, and PI3K/Akt signaling pathways. Conversely, PLM increased the expression of GSTP1 and carbonyl reductase 1, two enzymes that counteract ROS effects. ROS inhibition by exogenous N-acetyl-l-cysteine suppressed DC maturation. PLM treatment improved the severity of arthritis and reduced in vivo splenic DC maturation, collagen-specific CD4+ T cell responses, and ROS production in mice with collagen-induced arthritis. Taken together, these results suggest that PLM inhibits DC maturation by reducing intracellular ROS production and has potential as a therapeutic agent for rheumatoid arthritis.

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mentioning

confidence: 99%

Piperlongumine Suppresses Dendritic Cell Maturation by Reducing Production of Reactive Oxygen Species and Has Therapeutic Potential for Rheumatoid Arthritis

Xiao

Shi

Qiu

et al. 2016

The Journal of Immunology

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“…Fruits of the Piper longum contain piperine, piperonaline, piperoctadecalidine, piperlongumine which shows inhibitory potential on washed rabbit platelet aggregation [111]. All these acid amides shows dose-dependent inhibitory activity on washed rabbit platelet aggregation and the acid amide Piperlongumine shows stronger inhibitory effect than other acid amides to rabbit platelet aggregation induced by collagen, AA and PAF.…”

Section: Antiplatelet Effect Of Piperinementioning

confidence: 98%

Piperine and Its Various Physicochemical and Biological Aspects: A Review

Chopra¹,

Dhingra²,

Kapoor³

et al. 2016

CHEM

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Abstract:Piper nigrum L. is examined as the king of species worldwide by virtue of its principle piperine. In Ayurveda, since from the ancient times, it is known as "Yogvahi". It is one of the important alkaloids of Pepper fruits (Family Piperaceae) and has been found to have numerous medicinal properties such as antioxidant, antiplatelet, anti-inflammatory, antihypertensive, hepatoprotective, antithyroid, antitumor, antiasthmatic activity and also have significant role as fertility enhancer. The present review discusses the biosynthetic pathway, extraction process, chemistry and various analytical methods of piperine. It also describes the structural modification of piperine and its various effects on biological system. The utility of piperine as a bioenhancer for certain antibacterialantibiotics and a potent inhibitor of drug metabolism are also discussed. Thus, review provides knowledgeable erudition on the piperine which paves way for further work.

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“…Kandungan kimia tumbuhan genus Piper cukup beragam misalnya untuk senyawa non volatil adalah alkaloid amida (Ahn et al, 1992;Banerji. et al, 2002;Park et al, 2007;Marques et al, 2007), lakton (Dharmaratne et al, 2002), flavonoid (Portet et al, 2007) dan lignan (Usia et al, 2005;Cabanillas et al, 2010). Kandungan kimia dari bagian volatil tumbuhan Piper diantaranya monoterpen, seskuiterpen dan fenilpropanoid (Agnes et al,1986;Mundina et al, 1998;Martins et al, 1998;Dos Santos et al, 2001;Cysne et al, 2005;Elfahmi et al, 2006;Rali et al, 2007;Rahman et al, 2011).…”

Section: Pendahuluanunclassified

Komposisi Kimia Minyak Atsiri Buah Sirih Hijau (Piper Betle L), Kemukus (Piper Cubeba L) Dan Cabe Jawa (Piper Retrofractum Vahl)

Wartono

Ainurofiq

Ismaniar

2014

Molekul

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ABSTRAKTumbuhan genus Piper mempunyai kandungan minyak atsiri hampir disemua bagiannya, namun komposisi kimianya belum semua dilaporkan. Pada laporan ini kami melakukan isolasi dan identifikasi senyawa kimia minyak atsiri pada bagian buah tumbuhan Piper. Isolasi minyak atsiri buah Piper dilakukan dengan destilasi air menggunakan destilasi Stahl dan analisis komposisi kimia dengan kromatografi gasspektroskopi masa (GC-MS). Kandungan minyak atsiri buah sirih hijau (Piper betle) 1,4% (v/b), cabe jawa (Piper retrofractum) 1% (v/b), dan buah kemukus (Piper cubeba) 1,7% (v/b). Hasil analisis GC-MS menunjukan kandungan utama minyak atsiri adalah senyawa golongan monoterpen, seskuiterpen dan fenil propanoid. Kandungan utama minyak atsiri buah sirih hijau (P. betle) adalah eugenol (12,36%), isokaryofillena (9,55%) dan β-selinena (8,09%), sedangkan komponen utama buah cabe jawa (Piper retrofractum) adalah isokaryofilen (8,88%), β-bisabolen (7,01%) dan zingiberen (6,32%), dan minyak atsiri buah kemukus (Piper cubeba) adalah spathulanol (27,05%), sativen (8,73%) dan germakren D (7,50%).Kata kunci : Piperaceae, Buah, Piper betle, Piper retrofractum, Piper cubeba. ABSTRACTThe Piper genera contains essential oil in all part of the whole plant, but its chemical composition has not been completely reported. In this report we isolated and identified the chemical composition of essential oil from the fruits of Piper. The essential oil of Piper fruits were obtained by Stahl hydrodistilation and analyzed by GC-MS. The oil yielded 1.4% (v/w) of Piper betle, 1% (v/w) of Piper retrofractum, and 1.7% (v/w) of Piper cubeba. The chemical compositions were analyzed by GC-MS showing the presences of monoterpenes, sesquiterpenes, and phenyl propanoids. The major components of P. betle were eugenol (12.36%), isocaryophyllene (9.55%) and β-selinene (8.09%), whereas the Piper retrofractum were isocaryophyllene (8.88%), β-bisabolene (7.01%), and zingiberene (6.32%), and the P. cubeba were spathulanol (27.05%), sativen (8.73%) and germacrene-D (7.50%).

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Antiplatelet effects of acidamides isolated from the fruits of Piper longum L.

Cited by 77 publications

References 11 publications

Piperlongumine Suppresses Dendritic Cell Maturation by Reducing Production of Reactive Oxygen Species and Has Therapeutic Potential for Rheumatoid Arthritis

Piperlongumine Suppresses Dendritic Cell Maturation by Reducing Production of Reactive Oxygen Species and Has Therapeutic Potential for Rheumatoid Arthritis

Piperine and Its Various Physicochemical and Biological Aspects: A Review

Komposisi Kimia Minyak Atsiri Buah Sirih Hijau (Piper Betle L), Kemukus (Piper Cubeba L) Dan Cabe Jawa (Piper Retrofractum Vahl)

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