Antiplatelet Therapy for Secondary Prevention of Vascular Disease Complications

Goli, Rahul R.; Contractor, Mayur M.; Nathan, Ashwin S.; Tuteja, Sony; Kobayashi, Taisei; Giri, Jay

doi:10.1007/s11883-017-0698-2

Cited by 25 publications

(17 citation statements)

References 87 publications

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“…With the growing number of elders, warfarin and aspirin are used increasingly for a wide variety of applications [11,12]. Although Intracerebral hemorrhage (ICH) is a well-known complication resulting from warfarin and aspirin, warfarin and aspirin associated intraspinal hematoma, especially spinal intramedullary hemorrhage, has been reported rarely.…”

Section: Discussionmentioning

confidence: 99%

Low-dose warfarin combined with low-dose aspirin associated Spinal intramedullary hemorrhage: a case report

Zhou

Liu

Zhang

et al. 2020

Preprint

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Background:Spinal intramedullary hemorrhage is a rare event, the disease still has not received enough attention and many characteristics of the disease have not been sufficiently explored. Due to its rarity, it can easily be forgotten or misdiagnosed. Case presentation:We report a case of 72-year-old male patient with a medical history of coronary heart disease, atrial fibrillation (AF), hypertension, cervical spondylosis, carotid and vertebral artery stenosis with low-dose anticoagulation combined with low-dose antiplatelet therapy who suffered from sudden posterior neck and back pain for 3 hours visited our emergency department (ED). The International Normalization Ratio (INR) were controlled well, and other laboratory tests were within normal limits or only slightly abnormal. However, the patient was diagnosed with spinal intramedullary hemorrhage and died finally. Conclusion:Anticoagulation combined with antiplatelet-associated rare and life-threatening complications should be paid more attention.

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Section: Discussionmentioning

confidence: 99%

Low-dose warfarin combined with low-dose aspirin associated Spinal intramedullary hemorrhage: a case report

Zhou

Liu

Zhang

et al. 2020

Preprint

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“…Although there is sufficient evidence that aspirin is beneficial in secondary cardiovascular prevention ( 1 , 2 ), the results of clinical trials and meta-analyses comparing aspirin benefit in primary prevention are not homogenous ( 8 - 13 ). Antithrombotic Trialists’ Collaboration meta-analysis included six primary prevention trials with 95.000 patients at low risk for cardiovascular events ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

“…Aspirin is a well-accepted drug for the secondary prevention of atherosclerotic cardiovascular events ( 1 ). The role of aspirin in reducing cardiovascular mortality and repeat events after acute myocardial infarction was first demonstrated nearly 30 years ago ( 2 ), and since then similar results have been demonstrated by several groups when aspirin is used for the secondary prevention of cardiovascular events ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Design and Rationale for the ASSOS Study: Appropriateness of Aspirin Use in Medical Outpatients; A Multicenter and Observational Study

Çeli̇k¹

2018

Anatol J Cardiol

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Objective:The aim of this study was to describe the current status of aspirin use and the demographic characteristics of patients on aspirin for primary and secondary prevention of cardiovascular diseases.Methods:The Appropriateness of Aspirin Use in Medical Outpatients: A Multicenter, Observational Study (ASSOS) trial was a multicenter, cross-sectional, and observational study conducted in Turkey. The study was planned to include 5000 patients from 14 cities in Turkey. The data were collected at one visit, and the current clinical practice regarding aspirin use was evaluated (ClinicalTrials.gov number NCT03387384).Results:The study enrolled all consecutive patients who were admitted to the outpatient cardiology clinics from March 2018 until June 2018. Patients should be at least 18 years old, have signed written informed consent, and on aspirin (80–325 mg) therapy within the last 30 days. Cardiologists from the hospital participates in the study. Patients were divided into 2 categories according to presence or absence of atherosclerotic cardiovascular disease, namely secondary prevention group and primary prevention group, respectively. The appropriate use of aspirin in the primary and secondary prevention groups was assessed according to the European Society of Cardiology guidelines and US Preventive Services Task Force. The patients’ gastrointestinal bleeding risk factors and colorectal cancer risk were evaluated.Conclusion:The ASSOS registry will be the most comprehensive and largest study in Turkey evaluating the appropriateness of aspirin use. The results of this study help understand the potential misuse of aspirin in a real-world setting.

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“…However, aspirin, also known as the acetylsalicylic acid, accounted for 90% of all NSAIDs used. Since aspirin serves an important role in the primary and secondary prevention of cardiovascular and cerebrovascular diseases, it has become the most widely used NSAID (15). Data were collected from electronic case systems.…”

Section: Methodsmentioning

confidence: 99%

Thromboelastography‑derived parameters for the prediction of acute thromboembolism following non‑steroidal anti‑inflammatory drug‑induced gastrointestinal bleeding: A retrospective study

et al. 2018

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Efficacy of thromboelastography (TEG)-derived parameters for the prediction of acute thromboembolism (AT) in patients with non-steroidal anti-inflammatory drug (NSAID)-induced gastrointestinal bleeding (GIB) remains to be determined. A retrospective propensity score matching (PSM) study was performed to evaluate this efficacy. Patients with NSAID-induced GIB (98 with AT; 830 without AT) were matched for age, sex and history of cardiovascular and cerebrovascular diseases using PSM. Multivariate logistic regression was used to determine the efficacy of TEG-derived predictors of AT. Mean Decrease Gini (MDG) coefficients were used to rank the importance of the variables from random forest algorithm results. Univariate analysis indicated that the following indexes were significantly different between the two groups: Reaction time (R value), coagulation forming time, solidification angle, maximum amplitude (MA), coagulation index (CI), hemoglobin levels, D-dimer levels, platelet aggregation test (pAgt) results, fibrinogen levels and Acute Physiology and Chronic Health Evaluation II score (all P<0.001). Multifactor logistic regression analysis indicated that the R value (P=0.010), solidification angle (P=0.004), MA (P=0.038), D-dimer levels (P=0.012) and pAgt results (P=0.015) were independent predictors of AT in patients with NSAID-induced GIB, achieving an area under the curve of 0.999 in receiver operating characteristic curve analyses. The five most important parameters according to the MDG scores (MDGS) were: Solidification angle (MDGS=58.14), R value (MDGS=20.42), pAgt results (MDGS=15.61), D-dimer levels (MDGS=12.78) and CI (MDGS=12.61). The results of the present study indicated that TEG-derived parameters including the R value, solidification angle, MA and CI, as well as D-dimer levels and pAgt score were significant predictors of AT in patients with NSAID-induced GIB.

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Antiplatelet Therapy for Secondary Prevention of Vascular Disease Complications

Cited by 25 publications

References 87 publications

Low-dose warfarin combined with low-dose aspirin associated Spinal intramedullary hemorrhage: a case report

Low-dose warfarin combined with low-dose aspirin associated Spinal intramedullary hemorrhage: a case report

Design and Rationale for the ASSOS Study: Appropriateness of Aspirin Use in Medical Outpatients; A Multicenter and Observational Study

Thromboelastography‑derived parameters for the prediction of acute thromboembolism following non‑steroidal anti‑inflammatory drug‑induced gastrointestinal bleeding: A retrospective study

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