Antipneumococcic Serum Treatment of Pneumonia, With Report of Cases.

Tyler, George

doi:10.1001/jama.1901.52470220014001c

JAMA

1901

DOI: 10.1001/jama.1901.52470220014001c

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Antipneumococcic Serum Treatment of Pneumonia, With Report of Cases.

George Tyler¹

Abstract: Opisthorchis sinensis, while the Russian troops-with whom our troops have been associated-are subject to 0. felineus (0. tenuicollis) ; hence some of the liver troubles of which our

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2013

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Fred Neufeld and pneumococcal serotypes: foundations for the discovery of the transforming principle

Eichmann

Krause

2013

Cell. Mol. Life Sci.

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During the first decade of the twentieth century, the German bacteriologist Fred Neufeld, later Director of the Robert Koch-Institute in Berlin, first described the differentiation of pneumococci into serotypes on the basis of type-specific antisera. This finding was essential for subsequent research at the Rockefeller Institute of Medical Research (RIMR) in New York, and elsewhere, aiming for the conquest of human pneumococcal pneumonia, including antiserum therapy, the discovery that the type-specific antigens were carbohydrates, and the development of effective multivalent pneumococcal polysaccharide vaccines. Moreover, on the basis of pneumococcal serotypes Fred Griffith, in 1928 in London, discovered pneumococcal transformation, and Oswald T. Avery and coworkers, in 1944 at RIMR, identified DNA as the transforming substance. This sequence of events, leading to today's knowledge that genes consist of DNA, was initiated by a farsighted move of Simon Flexner, first Director of the RIMR, who asked Neufeld to send his pneumococcal typing strains, thus setting the stage for pneumococcal research at RIMR. Here, we describe Fred Neufeld's contributions in this development, which have remained largely unknown.

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Fred Neufeld and pneumococcal serotypes: foundations for the discovery of the transforming principle

Eichmann

Krause

2013

Cell. Mol. Life Sci.

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Antipneumococcic Serum Treatment of Pneumonia, With Report of Cases.

Abstract: Opisthorchis sinensis, while the Russian troops-with whom our troops have been associated-are subject to 0. felineus (0. tenuicollis) ; hence some of the liver troubles of which our

Cited by 1 publication

References 2 publications

Fred Neufeld and pneumococcal serotypes: foundations for the discovery of the transforming principle

Fred Neufeld and pneumococcal serotypes: foundations for the discovery of the transforming principle

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