Antiproliferation of melanoma cells by polysaccharide isolated from Zizyphus jujuba

Hung, Chi‐Feng; Hsu, Bo‐Yang; Chang, Shyh-Chung; Chen, Bing‐Huei

doi:10.1016/j.nut.2011.05.009

Cited by 70 publications

(36 citation statements)

References 25 publications

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“…6.44 ± 0.04 AB,d 6.45 ± 0.03 A,b 6.36 ± 0.02 CD,c 6.42 ± 0.02 AB,c 6.40 ± 0.02 BC,b 6.34 ± 0.02 D,bc 6.45 ± 0.02 A,c 10 6.41 ± 0.01 A,d 6.42 ± 0.02 A,b 6.32 ± 0.02 C,d 6.37 ± 0.01 B,d 6.37 ± 0.02 B,c 6.31 ± 0.02 C,c 6.37 ± 0.03 B,d 15 6.61 ± 0.04 A,a 6.52 ± 0.01 B,a 6.46 ± 0.01 C,a 6.52 ± 0.02 B,a 6.44 ± 0.01 CD,a 6.42 ± 0.02 D,a 6 the BSFs, therefore oxidation rate could be consequently decreased [36]. An increase in antioxidant activities of NEO and JG at high concentrations may thus lead to the better inhibition of lipid degradation due to the more presence of bioactive phenolic compounds, hexahydrofarnesyl acetone, neophytadiene, ␤-ionone and phytol [7,9].…”

Section: Chemical Quality Propertiesmentioning

confidence: 99%

Effect of novel bioactive edible coatings based on jujube gum and nettle oil-loaded nanoemulsions on the shelf-life of Beluga sturgeon fillets

Gharibzahedi

Mohammadnabi

2017

International Journal of Biological Macromolecules

126

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Section: Chemical Quality Propertiesmentioning

confidence: 99%

Effect of novel bioactive edible coatings based on jujube gum and nettle oil-loaded nanoemulsions on the shelf-life of Beluga sturgeon fillets

Gharibzahedi

Mohammadnabi

2017

International Journal of Biological Macromolecules

126

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“…ZJ might be a pivotal candidate for the dietary intervention against colon cancer. ZJ crude extracts isolated using different solvents was shown to be effective against hepatoma by inducing apoptosis and cell cycle arrest at the G2/M phase (Huang et al, 2007;Hung et al, 2012). PHY906, is a decoction of a mixture of four herbs, one of it is ZJ Mill.…”

Section: 7561 Dietary Ziziphus Jujuba Fruit Influence On Aberrant Crmentioning

confidence: 99%

Dietary Ziziphus jujuba Fruit Influence on Aberrant Crypt Formation and Blood Cells in Colitis-Associated Colorectal Cancer Mice

Periasamy¹,

Liu²,

Wu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Ziziphus jujuba (ZJ) fruit is rich in bioactive functional components such as polysaccharides, triterpenoid acid, flavonoids and oleamide. It has been commonly used in the treatment of various diseases including diabetes, digestive disorders, diarrhea, skin infections, liver and urinary diseases. However, its dietary effect on chemoprevention of colon cancer has never been studied. The present study was to evaluate the protective effects of dietary ZJ on colitis-associated colon carcinogenesis in azoxymethane (AOM)-dextran sodium sulphate (DSS)-treated mice. AOM was injected (10 mg/kg b.wt., i.p.) and three cycles of 2% DSS in drinking water for 7 days with 14 days of normal drinking water in-between was administered to induce colitis-associated colon cancer. ZJ fruit was supplemented in feed as 5 and 10%. Dietary ZJ significantly attenuated aberrant crypt foci (ACF) formation thereby decreasing the progression of hyperplasia to dysplasia. In addition, it significantly reduced circulating white blood cells, lymphocytes, neutrophils, monocytes, eosinophils, basophils and platelets compared to colon cancer mice. We conclude that ZJ supplementation delayed the progression of colon cancer from hyperplasia to dysplasia and ultimately adenocarcinoma and cancer. In addition, it decreased circulating tumor-related leucocytes, main regulators of cancer inflammation. Therefore, dietary consumption of ZJ fruit attenuated the formation of ACF and delayed the progression of colon cancer.

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“…The effectiveness of Z. jujuba has also been demonstrated against some cancer cell lines. For instance, Z. jujuba extracts could be used independently or in combination with other plants to induce apoptosis and exert cytotoxic effects on breast cancer (7)(8)(9), human hepatoma (HepG2) (10), human cervical carcinoma, human larynx carcinoma, T-cell leukemia (11), and melanoma cell lines (12).…”

Section: Introductionmentioning

confidence: 99%

Anti-Proliferative and Apoptotic Effects of Aqueous Extract of Ziziphus Jujube in Human Thyroid Carcinoma Cell Lines (C643)

et al. 2018

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Background: Ziziphus jujuba, which is known as "Annab" or "Onnab" in Iran, is an effective compound against some cancer cell lines. The present study aimed to investigate the anti-mutagenic and anticancer effects of the aqueous extract of Z. jujuba on C643 human thyroid carcinoma cells. Methods: C643 cells were cultured in (Roswell Park memorial institute) RPMI 1640 medium (Sigma) supplemented with 10% fetal bovine serum (FBS), penicillin-streptomycin, and L-glutamine. After incubating the cultures at 37ºC with 5% CO2, MTT assay was used to determine the inhibitory effect of Z. jujuba on cell proliferation. Cell cycle progression was monitored by sub-G1 apoptosis assay using flow cytometry. Finally, anti-mutagenicity properties of the extract were evaluated using a standard reverse mutation assay (Ames test), which was performed with a histidine auxotroph strain of Salmonella typhimurium (TA100) and exposure to a carcinogenic substance (sodium azide). Results: The aqueous extract of Z. jujuba inhibited the growth of C643 cells in a concentration range of 0.5 -2 mg/mL and exhibited cytotoxic effects on C643 cells in a concentration-dependent manner (IC50: 1.671 mg/mL). The mechanism of action was the induction of apoptosis in the cells. The results of Ames test indicated a significant difference in the anti-mutagenic effects of Z. jujuba aqueous extract and controls (distilled water and sodium azide) (1.671 mg/mL) (P < 0.01). In addition, the herbal extract prevented reverted mutations and the hindrance percent was 87.97%. Conclusions: According to the results, the aqueous extract of Z. jujuba fruit exerted anti-proliferative and apoptotic effects on C643 thyroid carcinoma cell lines and may be potentially useful as an anticancer agent.

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Antiproliferation of melanoma cells by polysaccharide isolated from Zizyphus jujuba

Cited by 70 publications

References 25 publications

Effect of novel bioactive edible coatings based on jujube gum and nettle oil-loaded nanoemulsions on the shelf-life of Beluga sturgeon fillets

Effect of novel bioactive edible coatings based on jujube gum and nettle oil-loaded nanoemulsions on the shelf-life of Beluga sturgeon fillets

Dietary Ziziphus jujuba Fruit Influence on Aberrant Crypt Formation and Blood Cells in Colitis-Associated Colorectal Cancer Mice

Anti-Proliferative and Apoptotic Effects of Aqueous Extract of Ziziphus Jujube in Human Thyroid Carcinoma Cell Lines (C643)

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