Antiproliferative Activities of Water Infusions from Leaves of Five Cornus L. Species

Forman, Vladimír; Haladová, M; Grančai, D; Ficková, M

doi:10.3390/molecules201219786

Cited by 25 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The total polyphenol amount was about 105 mg GAE/100 ml of extract which is threefold higher than the total polyphenol concentration in Crataegus monogyna evaluated in the same study [14]. According to Forman et al, the total polyphenol concentration in water extract is estimated to be approximately 8.3% [64]. In their second study, Forman et al noted that the concentration of flavonoids present in Cornus mas leaves (0.21%) is lower than for Cornus kousa, another edible Cornaceae species [65].…”

Section: Phytocompounds Composition In Cornus Mas Leavesmentioning

confidence: 79%

Functional properties of Cornelian cherry (Cornus mas L.): a comprehensive review

Szczepaniak

Kobus‐Cisowska

Kusek

et al. 2019

Eur Food Res Technol

View full text Add to dashboard Cite

Cornus mas, also known as the Cornelian cherry, is a plant that grows in Eastern Europe and the Middle East. Its green leaves and reddish oval fruits are associated with many beneficial properties such as antioxidative and anti-inflammatory effects. These features are driven by the rich polyphenolic composition, with anthocyanins and iridoids in Cornelian cherry fruits as well as flavonoids and phenolic acids in leaves. The antioxidant behavior as well as the composition significantly depends on the cultivar of the plant and its genotype. The functional properties of Cornelian cherry have been recognized in many in vitro and toxicological studies. Cornus mas fruits and their extracts have been found to have significant antiatherogenic, anti-inflammatory, and neuroprotective effects. The beneficial effect of C. mas fruits as a food component has been determined in numerous papers focused on functional food. However, there is no information in existing literature about C. mas leaves in functional food applications. This paper presents the results of current studies including their synthesis to answer the question whether the Cornelian cherry exhibits positive properties due to its bioactive compound content.

show abstract

Section: Phytocompounds Composition In Cornus Mas Leavesmentioning

confidence: 79%

Functional properties of Cornelian cherry (Cornus mas L.): a comprehensive review

Szczepaniak

Kobus‐Cisowska

Kusek

et al. 2019

Eur Food Res Technol

View full text Add to dashboard Cite

show abstract

“…This may explain the stronger cytotoxic effect of C. mas extract on Caco-2 cells. The anti-proliferative activity of extracts obtained from C. mas flowers, leaves, and fruits has been demonstrated in the literature [36][37][38][39][40], as well as the activity of A. melanocarpa leaves, fruits, and stems [41][42][43][44] against cancer cells. To our knowledge, there have been no previous studies on the cytotoxicity of C. superba extracts.…”

Section: Discussionmentioning

confidence: 94%

“…Forman et al [37] demonstrated that water extracts obtained from the leaves of the Cornus L. species C. mas, C. alba, C. flaviramea, C. kousa, and C. officinalis had a marked cytotoxic effect against human breast cancer cells (MCF-7) after only 24 h. The most effective extracts were from C. officinalis, C. mas, and C. alba, which decreased the survival of cells by up to 10.3%, 11.1%, and 11.2%, respectively. It was also observed that the anti-proliferative activity of the extracts was positively correlated with the total polyphenol and tannin content.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic and DNA-Damaging Effects of Aronia melanocarpa, Cornus mas, and Chaenomeles superba Leaf Extracts on the Human Colon Adenocarcinoma Cell Line Caco-2

Efenberger-Szmechtyk

Nowak

2020

Antioxidants

View full text Add to dashboard Cite

Aronia melanocarpa, Cornus mas, and Chaenomeles superba leaf extracts contain large amounts of bioactive compounds—mainly polyphenols, which possess many health benefits including anti-cancer properties. Here, we investigate the biological effects of A. melanocarpa, C. mas, and C. superba leaf extracts on the human colon adenocarcinoma cell line Caco-2. The antiproliferative activity of the extracts was measured using the MTT assay. The most cytotoxic extract was C. mas (IC50 = 0.60%). The extracts caused morphological changes in the Caco-2 cells, including partial detachment of cells, necrotic cells, chromatin condensation, cytoplasmic vacuolization, cell nuclei lysis, and nucleus fragmentation. The DNA damage in the Caco-2 cells after exposure to the leaf extracts was measured using the alkaline comet assay. The extracts increased DNA damage in a concentration dependent manner. However, at lower non-cyto- and non-genotoxic (IC0) concentrations the extracts induced DNA repair in Caco-2 cells after exposure to hydrogen peroxide. In conclusion, the results of these studies suggest that A. melanocarpa, C. mas and C. superba leaf extracts can show anticancer activity. However, further research is required on the mechanisms of anti-cancer activity by these extracts, with the application of more advanced and wide-ranging techniques including in vivo experiments.

show abstract

“…In their study, Forman et al, evaluated the anti-proliferative activity of water infusions from the leaves of fi ve Cornus L. types and their in vitro anti-proliferative activities proceeded on water extracts (lyophilisates) of the selected Cornus types, in human breast carcinoma MCF-7 cells. The current results indicated that all the extracts tested showed dose and time dependent anti-proliferative effects and the strongest of the selected types were obtained from CO, CM and CA types (33). In recent studies it was reported that C. mas L extract in all the cancer cells reduced cell viability below 26 % even at the lowest doses (34,35).…”

Section: Discussionmentioning

confidence: 52%

The investigation of the antitumoral effect of Cornus mas L in mice with ehrlich solid tumor

Yılmaz¹,

Alpa²,

Göçmen³

et al. 2020

BLL

View full text Add to dashboard Cite

AIM: Cornus mas L is commonly used due to its anti-infl ammatory, anti-carcinogenic and anti-oxidant properties. In the study, the effects of C. mas L extract on a solid tumor were examined in the Ehrlich solid tumor model developed in Balb/C type mice. METHODS: Ehrlich acid tumor (EAT) cells (1x10 6 EAT cell) from the stock animal were injected subcutaneously (s.c.) through the nape of the mice. Treatment groups of solid tumor-induced animals received 100 mg/kg and 200 mg/kg of C. mas L extract intraperitoneally (i.p.) for 14 days. RESULTS: Tumor volumes and animal weights were found to be statistically signifi cant compared to the control group (p < 0.05). AgNOR staining was performed in tumor tissues. Statistically signifi cant differences were observed between the groups in terms of TAA/NA ratio (p < 0.05). Immunohistochemical and biochemical parameters were also evaluated. An estimation of tumor proliferation of the lung, liver, brain, kidney, testis and tumor antioxidant parameters viz. lipid peroxidation, reduced glutathione (GSH), glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) was made. CONCLUSIONS: Our study showed that the anti-tumor effect of C. mas L in assisted tumor development with EAT cells, was mediated by the enhancement of oxidative stress with multiple mechanisms (Tab. 6, Fig. 12, Ref. 38).

show abstract

Antiproliferative Activities of Water Infusions from Leaves of Five Cornus L. Species

Cited by 25 publications

References 15 publications

Functional properties of Cornelian cherry (Cornus mas L.): a comprehensive review

Functional properties of Cornelian cherry (Cornus mas L.): a comprehensive review

Cytotoxic and DNA-Damaging Effects of Aronia melanocarpa, Cornus mas, and Chaenomeles superba Leaf Extracts on the Human Colon Adenocarcinoma Cell Line Caco-2

The investigation of the antitumoral effect of Cornus mas L in mice with ehrlich solid tumor

Contact Info

Product

Resources

About