Antiproliferative activity and constituents of leaf extracts of Croton sphaerogynus Baill. (Euphorbiaceae)

Motta, Lucimar Barbosa; Furlan, Cláudia Maria; Santos, Déborah Yara Alves Cursino dos; Salatino, Maria Luiza Faria; Negri, Giuseppina; Carvalho, João Ernesto de; Monteiro, Paula A.; Ruiz, Ana Lúcia T. G.; Caruzo, Maria Beatriz Rossi; Salatino, Antônio

doi:10.1016/j.indcrop.2013.08.008

Cited by 16 publications

(20 citation statements)

References 36 publications

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“…Over the past decades, natural products have attracted a great deal of attention due to their utilization of cancer prevention and treatment. Over 60% of anticancer drugs are derived from natural products [4]. Most anticancer drugs, such as taxol, camptothecin, vinblastine, vincristine and podophyllotoxin, originate from plant resources [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Over 60% of anticancer drugs are derived from natural products [4]. Most anticancer drugs, such as taxol, camptothecin, vinblastine, vincristine and podophyllotoxin, originate from plant resources [4,5]. The bioactive metabolites of plant extracts, such as phenolics, alkaloids and terpenoids, are considered as potential anticancer reagents [4,6,7].…”

Section: Introductionmentioning

confidence: 99%

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A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

Zhou

Chen

Lin

et al. 2019

Forests

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Cyclocarya paliurus (Batal.) Iljinskaja is an indigenous and multifunction tree species in China, but it is mainly used in pharmaceutical and nutraceutical ingredients. To make a comprehensive evaluation on its bioactive metabolites, antioxidant and antitumor potentials of C. paliurus leaves, the leaf samples were collected from 15 geographic locations (natural populations) throughout its distribution areas. High-performance liquid chromatography (HPLC) and colorimetric methods were used to detect the contents of bioactive metabolites. The antioxidant activity was evaluated by 2,2′-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and reducing power assays. The antiproliferative activity on different cancer cell types was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Contents of bioactive metabolites, and antioxidant and antiproliferative activities in the extracts were significantly affected by solvent and population. In most cases, the contents of flavonoids and triterpenoids, and the antioxidant and antiproliferative activities in the ethanol extracts were higher than the water extracts. The best scavenging capacity of DPPH (IC50 = 0.34 mg/mL) and ABTS (IC50 = 0.50 mg/mL) radical occurred in the ethanol extracts of S15 and S7 population respectively, while the strongest reducing power (EC50 = 0.71 mg/mL) was achieved in the ethanol extracts of S14 population. The antiproliferation effects of C. paliurus extracts on cancer cells varied with different cell types. The HeLa cell was the most sensitive to C. paliurus extracts, and their IC50 values of the ethanol extracts varied from 0.13 to 0.42 mg/mL among C. paliurus populations. Redundancy analysis showed that total polyphenol had the greatest contribution to the antioxidant activity, but total flavonoid was mostly responsible for the antiproliferation effects. These results would provide important scientific evidences not only for developing C. paliurus as a potent antioxidant and antitumor reagent, but also for obtaining the higher yield of bioactive compounds in the C. paliurus plantation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

Zhou

Chen

Lin

et al. 2019

Forests

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“…The genus contains various substances with biological activities such as against cancer -diterpenoids (clerodane, furoclerodane and acyclic diterpenes), alkaloids (taspine), and essential oils (Salatino et al, 2007). Essential oils have also been evaluated for their larvicidal efficacy against Aedes aegypti, amoebicidal, antifungal, and antimicrobial activities (Salatino et al, 2007;Souza et al, 2006;Rodrigues et al, 2009;Motta et al, 2013). These oils present variable components depending on the climate and soil conditions in which the specimens are found (Maia and Ming 1998).…”

Section: Introductionmentioning

confidence: 99%

Fixed and volatile constituents of Croton heliotropiifolius Kunth from Bahia-Brazil

Dourado¹,

Silva²,

Guédès³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Essential oils from Croton heliotropiifolius Kunth roots and stems, popularly known in Bahia (Brazil) as velame or cassutinga, were obtained by hydro distillation. Fixed oil from the roots of this species was obtained by maceration in hexane. The oils were analyzed by nuclear magnetic resonance (NMR) and gas chromatography coupled with mass spectrometry (GCMS). 46 compounds were identified in the stems and 35 substances were found in the roots. The principal components oils were camphor, β-pinene, a n d α-pinene in t h e stems, and camphor, borneol, valencene, and viridiflorol in the roots. The fixed oil contained C8 to C18 fatty acids. It is the first study that reports the presence of fixed oil from the roots of this genus.

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“…Recent studies have reported the antiproliferative properties of natural extracts that are known to contain molecules with high numbers of carbon atoms. However, few of these molecules are polycosanols as most are flavonoids, terpenoids or quinones [22,23,16,24,25,26].…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative evaluation of tall-oil docosanol and tetracosanol over CHO-K1 and human melanoma cells

Vergara

Olivares

Altamirano

2015

Electronic Journal of Biotechnology

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Background: Polycosanols derived from plant species have traditionally been used in medicine as antiproliferative agents for treating various viruses (primarily the herpes simplex virus). However, few studies have studied their effects on hyperproliferative cell lines. In this work, the antiproliferative capacity of polycosanols from tall-oil pitch, obtained from black liquor soaps in the kraft pulping process of cellulose (specifically from Pinus radiata, Pinus taede, and Eucalyptus globulus), was evaluated on CHO-K1 and CRL-1974 human melanoma cell lines. Results: The proliferative capacities and cell viabilities were measured for 72 and 140 h, respectively. Treatment with docosanol produced differential effects on the CHO-K1 and human melanoma cells and significantly affected their proliferation rates, but not their cell viabilities. Tetracosanol produced a significant negative effect on the proliferation of human melanoma cells, and this effect was less than that caused by docosanol. However, it had no effect on the proliferation of CHO-K1 cells and did not induce any significant effect on the viability of the studied cell lines. Conclusion: Docosanol and tetracosanol induced antiproliferative effects on the studied cell lines and exhibited significantly greater effects on the oncogenic cell lines. Prior to this study, the capacity of these polycosanols has never been investigated. Future studies will be necessary to determine their mechanisms of action on these cell systems.

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Antiproliferative activity and constituents of leaf extracts of Croton sphaerogynus Baill. (Euphorbiaceae)

Cited by 16 publications

References 36 publications

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

Fixed and volatile constituents of Croton heliotropiifolius Kunth from Bahia-Brazil

Antiproliferative evaluation of tall-oil docosanol and tetracosanol over CHO-K1 and human melanoma cells

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