Antiproliferative Activity of Cyano-Substituted Pyrans and 1,2,5,6,7,8-Hexahydroquinoline-3,3,4,4-Tetracarbonitriles

Антипролиферативная активность 2-галоген-5,6-дигидропиридин- и 2-галоген-4a,5,6,7-тетрагидрохинолин-3,4,4(1<I>H</I>)-трикарбонитрилов

“… ñîåäèíåíèÿõ 1d è 2a çà ñ÷åò îòñóòñòâèÿ îáúåìíûõ çàìåñòèòåëåé â ïîëîaeåíèÿõ 5 è 6 èìååòñÿ îòíîñèòåëüíî ñâîáîäíûé îäíîâðåìåííûé äîñòóï ê ýòèì ãðóïïàì. Äàííîå ïðåäïîëîaeåíèå ïîäòâåðaeäàåòñÿ íàëè÷èåì âûðàaeåííîé àêòèâíîñòè â ñëó÷àå 1,2,5,6,7,8-ãåêñàãèäðîõèíîëèí-3,3,4,4-òåòðàêàðáîíèòðèëîâ, â êîòîðûõ ìîëåêóëà èìååò áîëåå ïëîñêîå ñòðîåíèå [8].…”

Synthesis of Novel Hybrid 4H-Pyran-lipoic and 4H-Pyran-azetidine Derivatives

“…On the other hand, various studies have shown that the 4H-pyran core exhibits a wide range of biological activities such as antibacterial, 14 antiproliferative, 15 antipyretic, 16 and anti-inflammatory activity. 17 Our research group has conducted previous studies regarding this core, showing that this skeleton has vasorelaxant activity.…”