Antiproliferative Activity of Korean Wild Vegetables on Different Human Tumor Cell Lines

Abstract

This study was conducted to determine the antiproliferative activity of 24 Korean wild vegetables. The methanol extracts of these wild vegetables were used against lung, breast, colon and gastric cancer cells, and the results were assessed by MTT assay. It was found that at the extract concentration of 400 mgL(-1) 14 plants exercised antiproliferative activity over 80% against the lung cancer cells, one plant among six--against breast cancer cells, and two plants among six--against colon cancer cells, respectively. Eighteen wild vegetables had the hyperplasia inhibition activity against gastric cancer cells over 23.6% at all extract concentrations, however, only six plants had the antiproliferative activity over 80% in 600 mgL(-1). It was found that the extracts from Youngia sonchifolia, Synurus deltoides, Syneilesis palmata, and Cephalonoplos segetum, in concentration of 400 mgL(-1) inhibited the hyperplasia of lung cancer cells over 95% and Angelica gigas-both lung and colon cancer cells over 95%. In conclusion, the studied wild vegetables' methanol extracts possess dose dependent antiproliferative properties, based on their bioactive compounds, mainly polyphenols, but some of them as Hypericum ascyron against lung cancer are not effective and even course harm.

Ixeris dentata (Thunb. Ex Thunb.) Nakai Extract Inhibits Proliferation and Induces Apoptosis in Breast Cancer Cells through Akt/NF-κB Pathways

“…Overall, these data suggest that ID extract inhibits the growth of human breast cancer cells. In addition, the anti-proliferative effect of ID extract is consistent with the findings of previous studies in lung, liver, colon, and breast cancer cells [15,29]. Therefore, ID extract is believed to be an effective manner to inhibit breast cancer cell proliferation irrespective of ER.…”

Multidirectional Time-Dependent Effect of Sinigrin and Allyl Isothiocyanate on Metabolic Parameters in Rats

“…It has been estimated that diets rich in phytochemicals can significantly reduce cancer risk by as much as 20% [15]. Based on epidemiological observations, which correlated reduced incidence of cancer (particularly colon and rectal) in populations with intake of Brassicaceae family vegetables, biological studies have dealt with glucosinolates like sinigrin (SIN) and its hydrolysis product—allyl isothiocyanate (AITC).…”

Isolation of two new bioactive sesquiterpene lactone glycosides from the roots of Ixeris dentata

“…,11(13)-trien-12,6-olide (2), and 12 known sesquiterpene lactone derivatives (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) were isolated from the roots of Ixeris dentata. Their structures were determined by extensive spectroscopic methods including 1D and 2D NMR and MS spectra data.…”

“…1 It is also an important ingredient in Oriental therapies treating indigestion, pneumonia, hepatitis, contusions, tumors as well as adult diseases such as diabetes and liver diseases. [2][3][4][5][6] Aliphatics, triterpenoids and sesquiterpene glycosides are reported as the chemical constituents of I. dentata. Particularly, sesquiterpene lactones such as ixerin and ixerisoside derivatives are known to be unique structural components in genus Ixeris.…”

“…[7][8][9] Studies proved its antioxidant, anti-mutagenicity and anticancer properties and recent studies proved that I. dentata could be alternative source of anti-inflammatory agent. [3][4][5][6][10][11][12][13] The anti-inflammatory potential of the leaves of I. dentata extract was primarily due to contents of luteolin 7-Oglucoside and luteolin 7-O-glucuronide. 12 Other study also proved that the anti-inflammatory effects of the whole extract of I. dentata determined to be sesquiterpene lactone called tectroside.…”