Antiproliferative and Antioxidant Activities and Mycosporine-Like Amino Acid Profiles of Wild-Harvested and Cultivated Edible Canadian Marine Red Macroalgae

Athukorala, Yasantha; Trang, Susan; Kwok, Carmen; Yuan, Yue

doi:10.3390/molecules21010119

Cited by 56 publications

(36 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, the extraction of MAAs in marine macroalgae has been involved in many studies which were mainly concentrated on the distribution [64,69,92,95,114], profile [119], physiological activity [55,67,71,103,[120][121][122][123], properties [56,81,92,124,125], chemical characterization [54] of MAAs and effects of some environment factors on MAAs [36,54,66,74,79,80,86,[101][102][103]109,125,126]. However, further their isolation and purification did not conduct.…”

Section: Trends In Research On Maas In Marine Macroalgaementioning

confidence: 99%

“…In Rhodophytes, such as Acanthophora specifera [5], Chondrus crispus [73], Corallina officinalis [73], Cystoclonium purpureum [73], Lomentaria orcadensis [73], Mastocarpus stellata [73], Phycodrys rubens [73], Porphyra umbilicalis [73], and other red algae [2][3][4][5]7,[32][33][34][35]40,[42][43][44][45]55,69,71,[74][75][76][77][78][79], the proportion of mycosporine-glycine in MAAs was lower than 50%; and relatively numerous species (more than 260 species) did not detect this MAA, for instance, Actinotrichia fragilis [5], Ahnfeltiopsis devoniensis [39], Amphiroa rigida [2], Asparagopsis armata [4], and Bangia atropurpurea [3], etc. [1][2][3][4][5][40][41][42]44,55,58,<...>…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Distribution, Contents, and Types of Mycosporine-Like Amino Acids (MAAs) in Marine Macroalgae and a Database for MAAs Based on These Characteristics

et al. 2020

View full text Add to dashboard Cite

Mycosporine-like amino acids (MAAs), maximally absorbed in the wavelength region of 310–360 nm, are widely distributed in algae, phytoplankton and microorganisms, as a class of possible multi-functional compounds. In this work, based on the Web of Science, Springer, Google Scholar, and China national knowledge infrastructure (CNKI), we have summarized and analyzed the studies related to MAAs in marine macroalgae over the past 30 years (1990–2019), mainly focused on MAAs distribution, contents, and types. It was confirmed that 572 species marine macroalgae contained MAAs, namely in 45 species of Chlorophytes, 41 species of Phaeophytes, and 486 species of Rhodophytes, and they respectively belonged to 28 orders. On this basis, we established an open online database to quickly retrieve MAAs in 501 species of marine macroalgae. Furthermore, research concerning MAAs in marine macroalgae were analyzed using CiteSpace. It could easily be seen that the preparation and purification of MAAs in marine macroalgae have not been intensively studied during the past 10 years, and therefore it is necessary to strengthen the research in the preparation and purification of MAA purified standards from marine macroalgae in the future. We agreed that this process is not only interesting, but important due to the potential use of MAAs as food and cosmetics, as well as within the medicine industry.

show abstract

Section: Trends In Research On Maas In Marine Macroalgaementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distribution, Contents, and Types of Mycosporine-Like Amino Acids (MAAs) in Marine Macroalgae and a Database for MAAs Based on These Characteristics

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Inferring a single pair of enzymes to decarboxylate shinorine and porphyra-334 and further dehydrate their derivatives was also parsimonious in respect to the absence of a peak considered to be present in C. crispus based on UV+LC-MS or LC-MS/MS data [49,51]. We then verified using Pathmodel that constraining the pathway search with a molecule having a m/z ratio of 302,3177 leads to the same actual MAA2 as a proposed unique solution.…”

Section: New Candidate Enzymes For Decarboxylation and Dehydration Lementioning

confidence: 80%

“…Asterina-330 C12H20N2O6 yes [49] (LC-MS-MS); [ are given in S2 Table. Using LC-MS profiling, we confirmed, consistently with previous studies (see references in Table 2), the presence of six mycosporine-like aminoacids in C. crispus: asterina-330, palythene, palythine, palythinol, porphyra-334 and shinorine. Additionally, we identified mycosporine-glycine for the first time in C. crispus, and also found a peak at m/z=271.1 that does not match with any already identified candidate MAA, that we named it MAA1 in Table 2.…”

Section: Previous Evidencementioning

confidence: 99%

“…Additionally, we identified mycosporine-glycine for the first time in C. crispus, and also found a peak at m/z=271.1 that does not match with any already identified candidate MAA, that we named it MAA1 in Table 2. We also decided not to assign the peak at m/z=302,3117 to palytinol, as done previously [49,51], based on logical reasoning about this part of the pathway (see below). That is the reason why an other unknown compound, MAA2, appears in the table.…”

Section: Previous Evidencementioning

confidence: 99%

See 1 more Smart Citation

Inferring biochemical reactions and metabolite structures to cope with metabolic pathway drift

Belcour

Girard

Aïte

et al. 2018

Preprint

View full text Add to dashboard Cite

Inferring genome-scale metabolic networks in emerging model organisms is challenging because of incomplete biochemical knowledge and incomplete conservation of biochemical pathways during evolution. This limits the possibility to automatically transfer knowledge from well-established model organisms. Therefore, specific bioinformatic tools are necessary to infer new biochemical reactions and new metabolic structures that can be checked experimentally. Using an integrative approach combining both genomic and metabolomic data in the red algal model Chondrus crispus, we show that, even metabolic pathways considered as conserved, like sterol or mycosporine-like amino acids (MAA) synthesis pathways, undergo substantial turnover. This phenomenon, which we formally define as "metabolic pathway drift", is consistent with findings from other areas of evolutionary biology, indicating that a given phenotype can be conserved even if the underlying molecular mechanisms are changing. We present a proof of concept with a new methodological approach to formalize the logical reasoning necessary to infer new reactions and new molecular structures, based on previous biochemical knowledge. We use this approach to infer previously unknown reactions in the sterol and MAA pathways. Author summaryGenome-scale metabolic models describe our current understanding of all metabolic pathways occuring in a given organism. For emerging model species, where few biochemical data are available about really occurring enzymatic activities, such metabolic models are mainly based on transferring knowledge from other more studied species, based on the assumption that the same genes have the same function in the compared species. However, integration of metabolomic data into genome-scale metabolic models leads to situations where gaps in pathways cannot be filled by known enzymatic reactions from existing databases. This is due to structural variation in metabolic pathways accross evolutionary time. In such cases, it is necessary to use complementary approaches to infer new reactions and new metabolic intermediates using logical reasoning, based on available partial biochemical knowledge.Here we present a proof of concept that this is feasible and leads to hypotheses that are precise enough to be a starting point for new experimental work. the well-studied human pathogenic bacterium Mycobacterium tuberculosis, high throughput metabolomic screens revealed an unexpected diversity of reactions in central carbon metabolism [9]. Evolutionary models have already been developed to explain the arising of new pathways, with most experimental validations being focused so far at the level of individual enzyme activities [10]. The complementary question, how much conserved corresponding to Z-palythenic acid in C. crispus extracts, which does not support dehydration occuring before decarboxylation, as proposed in other species (Fig 4 and [65]). The structure of a new intermediate was therefore inferred manually, leading to MAA2 on Figure 8.Calculating its m/z ratio,...

show abstract

Algae: A Functional Food with a Rich History and Future Superfood

Rajauria

Yuan

2021

Recent Advances in Micro and Macroalgal Processing

View full text Add to dashboard Cite

Antiproliferative and Antioxidant Activities and Mycosporine-Like Amino Acid Profiles of Wild-Harvested and Cultivated Edible Canadian Marine Red Macroalgae

Cited by 56 publications

References 36 publications

Distribution, Contents, and Types of Mycosporine-Like Amino Acids (MAAs) in Marine Macroalgae and a Database for MAAs Based on These Characteristics

Distribution, Contents, and Types of Mycosporine-Like Amino Acids (MAAs) in Marine Macroalgae and a Database for MAAs Based on These Characteristics

Inferring biochemical reactions and metabolite structures to cope with metabolic pathway drift

Algae: A Functional Food with a Rich History and Future Superfood

Contact Info

Product

Resources

About