Antiproliferative and apoptotic effects of naringin on diethylnitrosamine induced hepatocellular carcinoma in rats

Thangavel, Prabu; Vaiyapuri, Manju

doi:10.1016/j.biomag.2013.01.006

Cited by 16 publications

(8 citation statements)

References 33 publications

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“…Results showed that treatment with naringin significantly reduced the levels of proliferating cell nuclear antigen (PCNA) and the argyrophilic nucleolar organizer region (AgNOR)/nuclei. Naringin also suppressed proliferation and enhanced apoptosis in the liver cancer cells of rats ( Thangavel and Vaiyapuri, 2013 ). In one study, cytotoxic actions of the synthesized binary and ternary platinum and vanadium metal complexes of naringin were evaluated using HepG2 cells.…”

Section: Anticancer Activities Of Naringinmentioning

confidence: 99%

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

et al. 2021

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Background: Natural product-based cancer preventive and therapeutic entities, such as flavonoids and their derivatives, are shown to have a noticeable capability to suppress tumor formation and cancer cell growth. Naringin, a natural flavanone glycoside present in various plant species, has been indicated to modulate different signaling pathways and interact with numerous cell signaling molecules, which allows for an extensive variety of pharmacological actions, such as amelioration of inflammation, oxidative stress, metabolic syndromes, bone disorders, and cancer. The purpose of this systematic review is to present a critical and comprehensive assessment of the antitumor ability of naringin and associated molecular targets in various cancers.Methods: Studies were identified through systematic searches of Science Direct, PubMed, and Scopus as well as eligibility checks according to predefined selection criteria.Results: Eighty-seven studies were included in this systematic review. There was strong evidence for the association between treatment with naringin alone, or combined with other drugs and antitumor activity. Additionally, studies showed that naringin-metal complexes have greater anticancer effects compared to free naringin. It has been demonstrated that naringin employs multitargeted mechanisms to hamper cancer initiation, promotion, and progression through modulation of several dysregulated signaling cascades implicated in cell proliferation, autophagy, apoptosis, inflammation, angiogenesis, metastasis, and invasion.Conclusion: The results of our work show that naringin is a promising candidate for cancer prevention and treatment, and might offer substantial support for the clinical application of this phytocompound in the future. Nevertheless, further preclinical and clinical studies as well as drug delivery approaches are needed for designing novel formulations of naringin to realize the full potential of this flavonoid in cancer prevention and intervention.

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Section: Anticancer Activities Of Naringinmentioning

confidence: 99%

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

et al. 2021

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“…27,28 During the induction of hepatocellular carcinoma, the major pathogenic mechanisms have been associated with the modulation in various cellular signaling pathways. 29,30 This pathway helps with therapeutic effects via delay, reduction, or prevention of tumerogenesis effects. Through the increased knowledge of oncogenic processes, this signaling pathway regulates tumor cell differentiation, proliferation, metastasis and invasion, which has led to the identification of numerous possible therapeutic targets that help develop molecular targeted therapies.…”

Section: Discussionmentioning

confidence: 99%

“…33 Lipid peroxidation is a well-known process that starts via free radical attack on one or more fatty acids and boosts/generates the numerous ranges of toxic metabolites including 4-hydroxynonenal and malondialdehyde. 11,30 These metabolites directly or indirectly attack the DNA and cause carcinogenicity and mutation. DEN-induced HCC is directly responsible for the boosted oxygen free radical metabolism.…”

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confidence: 99%

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Curcumae Ameliorates Diethylnitrosamine-Induced Hepatocellular Carcinoma via Alteration of Oxidative Stress, Inflammation and Gut Microbiota

Zhang¹,

Li²,

Li³

2021

JIR

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Background: Nonalcoholic fatty liver disease (NAFLD) increased the risk factor of hepatocellular carcinoma (HCC). NAFLD induces the hepatic-related cancer deaths mostly in middle-aged men. NAFLD enhanced the inflammatory reaction and oxidative stress in the hepatic tissue. Curcumae exhibited the anti-inflammatory and antioxidant effects. In this study, we made an attempt to scrutinize the protective effect of curcumae on obesity-induced HCC via alteration of inflammation, oxidative stress and gut microbiota. Methods: The rats used in this experiment were Wistar rats, 100 mg/kg intraperitoneal injection of diethylnitrosamine (hepatic carcinogen) was used at 2 weeks. After 6 weeks of the experimental study, the rats were randomly divided into high-fat diet (HFD) with or without curcumae-treated group rats and received the treatment for 22 weeks. Hepatic, nonhepatic, cardiac, antioxidant, pro-inflammatory and inflammatory were estimated at the end of the study. The stools of the experimental rats were collected for estimating the gut microbiota. Results: Curcumae-treated group rats exposed reduction of the hepatic nodules in hepatic tissue. Curcumae significantly (P<0.001) diminished the level of hepatic parameters and antioxidant parameters in the serum. Curcumae significantly (P<0.001) suppressed the proinflammatory cytokines level, viz. interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), interleukin-7 (IL-7) and augmented the level of interleukin-10 (IL-10) in the serum and hepatic tissue. Curcumae significantly (P<0.001) suppressed inflammatory mediators including cyclooxygenase (COX-2), prostaglandin E2 (PGE2) and nuclear factor kappa B (NF-κB) in the serum and hepatic tissue. Furthermore, curcumae increased the gut microbial diversity and richness and decreased the relative abundance of genus Mucispirillum and Clostridium, respectively. Conclusion: Curcumae prevents HFD-induced inflammation during the hepatic carcinoma by modulating the oxidative stress, inflammatory reaction and gut microbiota.

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“…Some rough endoplasmic reticulum emerged particle fusion and degranulation. Mitochondrions changed to vacuole 17 Microvilli and mitochondria with myeloid metaplasia were observed on the surface of Wrh-f2 and Wrh-s2.…”

Section: Bionomics Of 2 Cell Lines With Different Metastatic Potentialmentioning

confidence: 99%

Establishment of rat liver cancer cell lines with different metastatic potential

Song

Zhang

Zheng

et al. 2020

Sci Rep

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The gloomy outcome of liver cancer is mainly due to the high rates of metastasis and recurrence, even after curative resection for early stage liver cancer. Our study was conducted to find the animal model suitable for the study of liver cancer metastasis. In our study, two liver cancer cells were obtained from N-nitrosodiethylamine (DEN) and N-nitrosomorpholine (NMOR) induced rats, and they were cultivated, screened and cloning cultivated. Bionomics of cells was analyzed. The results show that 2 cells had different metastatic potentiality. They were named Wrh-f2 and Wrh-s2, and they have the characteristics of Hepatocellular carcinoma cells. The bionomics of 2 cells showed: (1) The chromosome karyotype analysis showed that the mode of Wrh-f2 was 80-83 and Wrh-s2 was 55-57; (2) AFP positive cytoplasmic staining was observed in Wrh-f2 and Wrh-s2. Cytokeratin (CK) 7 and CK8 positive staining was present in Wrh-f2. CK8 positive staining was present in Wrh-s2; (3) The numbers of Wrh-f2 and Wrh-s2 that passed through the Transwells were 98 ± 12 and 55 ± 15;(4) Wrh-f2 had the significant higher colony formation (78%) than Wrh-s2(8%) (P < 0.01). (5) The animal models generated solid tumours when 2 cells were inoculated to nude mouse and rat. And Wrh-f2 developed stable pulmonary metastasis. The established cell lines with different metastatic potential showed obvious advantages over liver cancer in mimicking the biological properties of malignant liver cancer tumors. It provided a suitable model for the mechanism of liver cancer metastasis in vivo and in vitro.

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Antiproliferative and apoptotic effects of naringin on diethylnitrosamine induced hepatocellular carcinoma in rats

Cited by 16 publications

References 33 publications

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

Curcumae Ameliorates Diethylnitrosamine-Induced Hepatocellular Carcinoma via Alteration of Oxidative Stress, Inflammation and Gut Microbiota

Establishment of rat liver cancer cell lines with different metastatic potential

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