Antiproliferative Effects of Free and Encapsulated <i>Hypericum Perforatum</i> L. Extract and Its Potential Interaction with Doxorubicin for Esophageal Squamous Cell Carcinoma

Amjadi, Issa; Mohajeri, Mohammad; Borisov, Andrei B.; Hosseini, Motaharesadat

doi:10.3831/kpi.2019.22.013

Cited by 7 publications

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…using hypericin-P123 photodynamic therapy described Conrado et al 2021. H. perforatum extract encapsulated in poly(lactic-co-glycolic acid) (PLGA) nanoparticles can successfully and specifically target esophageal squamous carcinoma cells (Amjadi et al 2019). The cellular uptake and phototoxicity of hypericin was enhanced by encapsulation into surface coated zein formulations (Abdelsalam et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial polyhydroxybutyrate submicron fiber mat loaded with extract of Hypericum perforatum

et al. 2022

View full text Add to dashboard Cite

The aim of this work was to prepare a new biodegradable polyhydroxybutyrate (PHB) submicron fiber mat loaded with hypericin-rich Hypericum perforatum raw extract by centrifugal spinning technology, an alternative approach to the traditional method of electrospinning to fabricate nanofibers or microfibers from solutions at high speed and low cost. Hypericins in methanol/acetone extract of H. perforatum were determined by UHPLC-MS/MS and HPLC/PDA. Submicron fiber mats composed of pure PHB or PHB enriched with H. perforatum extract were prepared using a pilot plant demonstrator for the centrifugal spinning technology and characterized by SEM. Singlet oxygen production was quantified by the 1,3-diphenylisobenzofuran (DPIBF) method in hexane. The results proved a significant production of singlet oxygen by the prepared submicron fiber mat. We also found a significant antibacterial activity against the bacterial strain Escherichia coli CCM 5417 by a method in accordance with JIS Z 2801/ISO 22196 standards. The H. perforatum extract-enriched PHB submicron fiber mats showed potential for the development of self-cleaning and antimicrobial air filters.

show abstract

Section: Introductionmentioning

confidence: 99%