Antiproliferative efficacy of lipophilic soy isoflavone phytoestrogens delivered by low density lipoprotein particles into cultured U937 cells

Meng, Qingguo; Wähälä, Kristiina; Adlercreutz, Herman; Tikkanen, Matti J.

doi:10.1016/s0024-3205(99)00418-x

Cited by 17 publications

(6 citation statements)

References 27 publications

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“…It has been previously revealed that genistein esterification with various fatty acids may increase its biological activity both in vitro and in vivo, by raising its cellular uptake [ 20 ]. Furthermore it has been proven that esterification may improve genistein stability and plasmatic life [ 21 ]. Another possibility to improve genistein solubility and, by consequence, bioavailability involves its entrapment inside branched cyclodextrins [ 7 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

PreliminaryIn VitroEvaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation

Danciu

Şoica

Dehelean

et al. 2015

Analytical Cellular Pathology

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The present study focuses on the synthesis and analysis of a genistein ester derivative with myristic acid followed by beta cyclodextrin encapsulation; physicochemical analysis using consecrated techniques such as FTIR, MS, DSC, and SEM revealed both a successful esterification and inclusion inside the cyclodextrin cavity. Cytotoxic effects were measured in vitro on three human cell lines: HeLa (cervix adenocarcinoma), A2780 (ovary carcinoma), and A431 (skin epidermoid carcinoma). The in vitro biological analysis exhibited rather poor antiproliferative results on all three tested cancer cell lines, behavior that may be due to the high stability of the complex within the in vitro environment.

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Section: Introductionmentioning

confidence: 99%

PreliminaryIn VitroEvaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation

Danciu

Şoica

Dehelean

et al. 2015

Analytical Cellular Pathology

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“…Numerous in vitro investigations have demonstrated that genistein has anti-cancer qualities against CRC and the methods by which it does so have been extensively studied. Genistein effectively by inhibiting the PI3K/Akt pathway inhibits colon cancer cell growth [ 89 , 90 ], which plays a vital role in colon cancer progression regulation. ERs expression and tumor-suppressor genes in colon cancer cells are also impacted by genistein [ 91 , 92 ].…”

Section: Review Methodologymentioning

confidence: 99%

Genistein: Therapeutic and Preventive Effects, Mechanisms, and Clinical Application in Digestive Tract Tumor

Hou

2022

Evidence-Based Complementary and Alternative Medicine

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Genistein is one of the numerous recognized isoflavones that may be found in a variety of soybeans and soy products, including tofu and tofu products. The chemical name for genistein is 4′, 5, 7-trihydroxyisoflavone, and it is found in plants. In recent years, the scientific world has become more interested in genistein because of its possible therapeutic effects on many forms of cancer. It has been widely investigated for its anticancer properties. The discovery of genistein’s mechanism of action indicates its potential for apoptosis induction and cell cycle arrest in gastrointestinal cancer, especially gastric and colorectal cancer. Genistein’s pharmacological activities as determined by the experimental studies presented in this review lend support to its use in the treatment of gastrointestinal cancer; however, additional research is needed in the future to determine its efficacy, safety, and the potential for using nanotechnology to increase bioavailability and therapeutic efficacy.

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“…It has been reported, however, that oxidized lipids in LDL are incorporated into the cells and detected in cell extracts [25]. Moreover, biologically active phytochemicals, incorporated into LDL and internalized by cultured cells via the LDLR pathway, have been shown to retain their biological activity [21].…”

Section: Transport Of Lipophilic Substances Other Than Plasma Lipidsmentioning

confidence: 99%

Lipid Oxidation Products and the Risk of Cardiovascular Diseases: Role of Lipoprotein Transport

Ahotupa

2024

Antioxidants

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Cholesterol has for decades ruled the history of atherosclerotic cardiovascular diseases (CVDs), and the present view of the etiology of the disease is based on the transport of cholesterol by plasma lipoproteins. The new knowledge of the lipoprotein-specific transport of lipid oxidation products (LOPs) has introduced another direction to the research of CVD, revealing strong associations between lipoprotein transport functions, atherogenic LOP, and CVD. The aim of this review is to present the evidence of the lipoprotein-specific transport of LOP and to evaluate the potential consequences of the proposed role of the LOP transport as a risk factor. The associations of cholesterol and lipoprotein LOP with the known risk factors of CVD are mostly parallel, and because of the common transport and cellular intake mechanisms it is difficult to ascertain the independent effects of either cholesterol or LOP. While cholesterol is known to have important physiological functions, LOPs are merely regarded as metabolic residues and able to initiate and boost atherogenic processes. It is therefore likely that with the increased knowledge of the lipoprotein-specific transport of LOP, the role of cholesterol as a risk factor of CVD will be challenged.

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Antiproliferative efficacy of lipophilic soy isoflavone phytoestrogens delivered by low density lipoprotein particles into cultured U937 cells

Cited by 17 publications

References 27 publications

PreliminaryIn VitroEvaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation

PreliminaryIn VitroEvaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation

Genistein: Therapeutic and Preventive Effects, Mechanisms, and Clinical Application in Digestive Tract Tumor

Lipid Oxidation Products and the Risk of Cardiovascular Diseases: Role of Lipoprotein Transport

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