Antiproliferative evaluation and supramolecular association in Mn(II) and Zn(II) bipyridine complexes: Combined experimental and theoretical studies

Bhattacharyya, Manjit K.; Gogoi, Anshuman; Chetry, Sanjib; Dutta, Debajit; Verma, Akalesh Kumar; Sarma, Bipul; Franconetti, Antonio; Frontera, Antonio

doi:10.1016/j.jinorgbio.2019.110803

Cited by 42 publications

(9 citation statements)

References 62 publications

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“…Both complexes show significant advancement over previous reports against DL cells especially complex 2 with IC 50 value of 5 μM. [26][27][28][53][54][55][56][57] electrochemical studies reveal remarkable activity of complexes towards OER. High OER activity and high stability of complex 2 under OER operative environment as compared with complex 1 can make complex 2 a promising candidate to replace the highly expensive noble metal-based catalysts.…”

Section: Comparative Study Of Synthesized Complexes With Previously Reported Complexesmentioning

confidence: 80%

“…[24] Most of these reports about 50% rely on noble metal platinum, [25] whereas only a few reports are available on non-noble metals like Mn, Co, and Ni. [26][27][28] Also, the activity of metallodrugs against Dalton's lymphoma (DL) cells is not explored much. So, it will be of interest to study the effect of non-noble metal complexes against DL cells through the metal ligated chemical complexes.…”

Section: Introductionmentioning

confidence: 99%

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Electrocatalytic oxygen evolution and antiproliferative activity of Co(III) complexes stabilized by in situ generated bis(5‐furan/phenyl‐1,2,4‐triazole)‐3‐sulfinamide

Bharty

Singh

Bharati

et al. 2021

Applied Organom Chemis

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Electrocatalytic water oxidation by transition metal complexes is an emerging area of research. Here, two cobalt(III) complexes [Co(ftsm)NH 3 (o-phen)]ÁH 2 O(1) {ftsm = bis(5-furan-1,2,4-triazole)-3-sulfinamide} and [Co(ptsm)NH 3 (o-phen)]ÁCH 3 OH (2) {ptsm = bis(5-phenyl-1,2,4-triazole)-3-sulfinamide} were synthesized and characterized by various spectroscopic and X-ray crystallography techniques. Complexes 1 and 2 were found to have admirable electrocatalytic activity towards oxygen evolution reaction (OER). The Tafel slope values for GC/Nf-Complex-2 and GC/RuO 2 were 53 and 60 mV/dec, respectively. Consequently, complex 2 possesses a better water oxidation response than standard material RuO 2 . The ligands Haftt, Haptt, o-phen, and complexes 1 and 2 were also tested for their cytotoxicity against Dalton's lymphoma (DL) cells employing MTT assay and found to have significant cytotoxicity. The IC 50 values of Haftt, Haptt, mixed ligands Haftt + o-phen and Haptt + o-phen, and complexes 1 and 2 against DL cells were found to be 150, 400, 200, 450, 80, and 5 μM, respectively. The complexes were found to have minimal effect on normal cells. The remarkable IC 50 value for complex 2 shows that it can be utilized as a potential anticancer agent against DL cells.

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Section: Comparative Study Of Synthesized Complexes With Previously Reported Complexesmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Electrocatalytic oxygen evolution and antiproliferative activity of Co(III) complexes stabilized by in situ generated bis(5‐furan/phenyl‐1,2,4‐triazole)‐3‐sulfinamide

Bharty

Singh

Bharati

et al. 2021

Applied Organom Chemis

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“…73 Viable cells with normal metabolic activities can effectively convert a yellow color MTT {3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide} dye into a purple colored formazan crystal which shows absorbance near 570 nm. 74 However, non-viable cells cannot convert the MTT dye into formazan crystals, therefore color formation acts as a convenient indicator for the presence of viable cells in a cell culture. Although the precise cellular mechanism of MTT reduction into formazan is still unknown, it is believed that the reduction of MTT takes place with the NADH or other reducing molecules which transfer electrons to MTT.…”

Section: Resultsmentioning

confidence: 99%

Structural topologies involving energetically significant antiparallel π-stacking and unconventional N(nitrile)⋯π(fumarate) contacts in dinuclear Zn(ii) and polymeric Mn(ii) compounds: antiproliferative evaluation and theoretical studies

et al. 2022

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“…It is clear that this is related to the toxicity of the co-ligands contained in the complexes. In some studies, it has been reported that the toxicity of compounds that cause approximately 10 % cell death in normal cells can be neglected and these compounds can be used as anticarcinogenic agents (Bhattacharyya et al, 2019;Nashre-ul-Islam et al, 2019). Since the ZnBrBADENA complex causes 13 % cell death at 62.5 ppm, it is thought that it could be used as an anticarcinogenic agent in future studies.…”

Section: Mtt Assaymentioning

confidence: 99%

Determination of Cytotoxicity of Zinc 2-Bromobenzoate with Nicotinamide and N,N'-Diethylnicotinamide Complexes

Akbaba

2020

Caucasian Journal of Science

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Benzoic acid and its derivatives and their metal complexes, which have antimicrobial, anticancer, antituberculosis and antioxidant properties, are biologically active molecules. Although there are many studies on the biological activity of these compounds, studies on the determination of their toxicity are limited. In the presented study, the cytotoxic properties of the previously synthesized diaquabis(2-bromobenzoato-κO)bis(nicotinamide-κN1)zinc(II) (ZnBrBANA) and diaquabis(2-bromobenzoato-κO)bis(N,N'-diethylnicotinamide-κN1)zinc(II) (ZnBrBADENA) complexes were investigated. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, a colorimetric method, was used to determine the cytotoxicity of complexes on human peripheral lymphocyte cells. Besides, cytotoxicity of dimethylsulfoxide (DMSO) which is crystal solvent and 2-bromobenzoic acid (BrBA), nicotinamide (NA), and N,N'-dietyhlnicotinamide (DENA) which are starting compounds of the complexes was also evaluated. According to the results of MTT method, It has been determined that both complexes and starting components except BrBA cause cytotoxicity on lymphocyte cells at the concentration range of 62.5-500 ppm. In addition, it was determined that the BrBA and DMSO at the same concentration range do not show any cytotoxic effect on lymphocyte cells. It was observed that the synthesized complexes were more toxic at each concentration than the starting components. Therefore, the toxic effects of the complexes used as drug active ingredients should be followed up with new studies.

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Antiproliferative evaluation and supramolecular association in Mn(II) and Zn(II) bipyridine complexes: Combined experimental and theoretical studies

Cited by 42 publications

References 62 publications

Electrocatalytic oxygen evolution and antiproliferative activity of Co(III) complexes stabilized by in situ generated bis(5‐furan/phenyl‐1,2,4‐triazole)‐3‐sulfinamide

Electrocatalytic oxygen evolution and antiproliferative activity of Co(III) complexes stabilized by in situ generated bis(5‐furan/phenyl‐1,2,4‐triazole)‐3‐sulfinamide

Structural topologies involving energetically significant antiparallel π-stacking and unconventional N(nitrile)⋯π(fumarate) contacts in dinuclear Zn(ii) and polymeric Mn(ii) compounds: antiproliferative evaluation and theoretical studies

Determination of Cytotoxicity of Zinc 2-Bromobenzoate with Nicotinamide and N,N'-Diethylnicotinamide Complexes

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