Electrocatalytic oxygen evolution and antiproliferative activity of Co(III) complexes stabilized by in situ generated bis(5‐furan/phenyl‐1,2,4‐triazole)‐3‐sulfinamide

Abstract

Electrocatalytic water oxidation by transition metal complexes is an emerging area of research. Here, two cobalt(III) complexes [Co(ftsm)NH 3 (o-phen)]ÁH 2 O(1) {ftsm = bis(5-furan-1,2,4-triazole)-3-sulfinamide} and [Co(ptsm)NH 3 (o-phen)]ÁCH 3 OH (2) {ptsm = bis(5-phenyl-1,2,4-triazole)-3-sulfinamide} were synthesized and characterized by various spectroscopic and X-ray crystallography techniques. Complexes 1 and 2 were found to have admirable electrocatalytic activity towards oxygen evolution reaction (OER). The Tafel slope values for GC/Nf-Complex-2 and GC/RuO 2 were 53 and 60 mV/dec, respectively. Consequently, complex 2 possesses a better water oxidation response than standard material RuO 2 . The ligands Haftt, Haptt, o-phen, and complexes 1 and 2 were also tested for their cytotoxicity against Dalton's lymphoma (DL) cells employing MTT assay and found to have significant cytotoxicity. The IC 50 values of Haftt, Haptt, mixed ligands Haftt + o-phen and Haptt + o-phen, and complexes 1 and 2 against DL cells were found to be 150, 400, 200, 450, 80, and 5 μM, respectively. The complexes were found to have minimal effect on normal cells. The remarkable IC 50 value for complex 2 shows that it can be utilized as a potential anticancer agent against DL cells.

Cd(II) complexes derived from thiazoline, hydrazide and carbodithioate ligands: synthesis, crystal structures and electrochemical sensing of uric acid

“…Owing to the presence of these heterocyclic moieties as ligands, transition metal complexes formed by them exhibited good biological and electrical properties. [21][22][23] Dithiocarbamates are a family of monoanionic 1, 1-dithio ligands that are simple to synthesize. They have the ability to form complexes with transition metal ions with a high efficiency.…”

Facile synthetic method for peptoids bearing multiple azoles on side chains

“…[6,7] The potential functionality of the metal sites of metalloenzymes, such as multicopper oxidases [8][9][10] and lipoxygenases [11][12][13][14] in which a transition metal (Cu or Fe) is stabilized by multiple imidazoles, has stimulated the exploration of azole-rich ligands bearing imidazole, pyrazole, triazole, and tetrazole moieties. These ligands have been utilized in metal catalysts for C H oxidation [15,16] and water oxidation, [17][18][19] as well as in metallodrugs such as antibiotics [20,21] and anticancer agents. [19,22] Thus, we consider that the incorporation of multiple azole moieties into peptoids is an attractive design principle for broadening the chemical diversity and applications of this class of peptidomimetics.…”

“…These ligands have been utilized in metal catalysts for C H oxidation [15,16] and water oxidation, [17][18][19] as well as in metallodrugs such as antibiotics [20,21] and anticancer agents. [19,22] Thus, we consider that the incorporation of multiple azole moieties into peptoids is an attractive design principle for broadening the chemical diversity and applications of this class of peptidomimetics. There are two main sites for introducing azoles into peptoids: the side chains [23] and the backbone (Figure 2a).…”