Antiprotease Activity in Plasma, Pulmonary Lymph and Bronchoalevolar Lavage Fluid in Anaesthetised Sheep before and after Administration of Endotoxin

Pai, Vidya; Briggs, B A; Snashall, P. D.; Tetley, TD

doi:10.1042/cs072026pb

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“…The fluid lost may be passing into adjacent acini or out of the alveolar space and into the interstitium. Data from a sheep model used in this laboratory [21) show that following lung lavage, lymphatic drainage from the lung increases, implying that lavage fluid is crossing into the interstitium and, thus, cannot be aspirated out of the lung. The low fluid recovery observed after PL in the present investigation was not a result of studying patients, since similar volumes are recovered from healthy volunteers after this type of lavage (Thn..EY et al, unpublished data).…”

Section: Discussionmentioning

confidence: 98%

Comparison of human lung surface protein profiles from the central and peripheral airways sampled using two regional lavage techniques

Smith¹,

Guz²,

Winning³

et al. 1988

Eur Respir J

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This study describes two new techniques of lung lavage which selectively remove material from the central airways, or from the lung below the seventh generation. Bronchograms confirmed that discrete regions of the lung were washed by central lavage (CL; maximum airway diameter approximately 6.5 mm) and peripheral lavage (PL; maximum airway diameter approximately 1.3 mm), and that both could be clearly distinguished from conventional bronchoalveolar lavage (BAL). These techniques were used to establish whether or not large-airway proteins made a major contribution to the protein profile of BAL. Twenty consecutive patients undergoing routine fibreoptic bronchoscopy were investigated. More bronchial mucus proteinase inhibitor per unit albumin and per unit total measured antiproteinase was present in CL than PL or BAL. In contrast alpha 1-proteinase inhibitor per unit albumin and as a percentage of total measured antiproteinase was lower in CL than in other lavage types. There were no differences in elastase activity, irrespective of the way in which the data were expressed. As no differences were found between BAL and PL for any of the variables measured, it was concluded that in the subjects studied the contribution of CL proteins to BAL was minimal.

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Section: Discussionmentioning

confidence: 98%