2019
DOI: 10.1111/bjd.17825
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Antipruritic effects of transient heat stimulation on histaminergic and nonhistaminergic itch

Abstract: Summary Background Chronic itch is notoriously difficult to treat. Counterstimuli are able to inhibit itch, but this principle is difficult to apply in clinical practice, and the mechanisms behind counterstimulation‐induced itch suppression in humans are unclear. Objectives Firstly, to analyse the stimulus–response effects of transient heat stimuli on histaminergic and nonhistaminergic itch, and secondly, to investigate whether the antipruritic effect depends on homotopic (peripheral mediation) or heterotopic … Show more

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Cited by 7 publications
(20 citation statements)
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References 70 publications
(163 reference statements)
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“…It has been widely re-ported that noxious heat (i.e. ≥45°C) can inhibit and, in certain conditions, even resolve the itch sensation (3)(4)(5).…”
Section: Discussionmentioning
confidence: 99%
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“…It has been widely re-ported that noxious heat (i.e. ≥45°C) can inhibit and, in certain conditions, even resolve the itch sensation (3)(4)(5).…”
Section: Discussionmentioning
confidence: 99%
“…Itch was provoked by 3 different substances and methods: histamine, serotonin, and cowhage. Histaminergic itch was evoked as described previously ( 5 ). Briefly, a drop of histamine chloride (1%; Diagenics, Milton Keynes, UK) was applied in the designated area on the skin in the centre of the area and punctured with a standard skin-prick test needle (Diagenics, Milton Keynes, UK).…”
Section: Methodsmentioning
confidence: 99%
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“…Histamine has to be introduced into the skin, to achieve an itch sensation. This can be done using a skin prick test, iontophoresis, intradermal injection and inactivated cowhage spicules soaked in a histamine solution 50,52,[73][74][75][76] . Another itch human model is achieved by the use of cowhage spicules already characterized in 1955 77,78 .…”
Section: Itch Human Modelsmentioning
confidence: 99%