Antipsychotic drugs prevent the motor hyperactivity induced by psychotomimetic MK-801 in zebrafish (Danio rerio)

Seibt, Kelly Juliana; Oliveira, Renata da Luz; Zimmermann, Fernanda Francine; Capiotti, Katiúcia Marques; Bogo, Maurı́cio Reis; Ghisleni, Gabriele; Bonan, Carla Denise

doi:10.1016/j.bbr.2010.06.014

Cited by 87 publications

(82 citation statements)

References 67 publications

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“…One way to create more disease relevant zebrafish models is to identify small molecule pre-treatments that recapitulate important clinical aspects of disease. For example, the sleep/wake screen found that MK-801 and other NMDA receptor antagonists used in drug-induced schizophrenia animal models (Olney et al, 1999) similarly increased locomotor behavior (Adriani et al, 1998;Rihel et al, 2010a), a result confirmed in other adult and larval zebrafish experiments (Swain et al, 2004;Chen et al, 2010;Seibt et al, 2010). The PMR screen identified paralysis in zebrafish treated with organophosphates (Kokel et al, 2010), a phenotype that was reversed by antidotes used to treat human organophosphate toxicity (Bajgar, 2004).…”

Section: Conceptual and Practical Lessonsmentioning

confidence: 80%

“…Recent experiments in both larval and adult zebrafish have tested the behavioral effects of psychotropic compounds, including drugs of abuse (Gerlai et al, 2000;Darland and Dowling, 2001;Bilotta et al, 2002;Dlugos and Rabin, 2003;Lockwood et al, 2004;Gerlai et al, 2006;Lau et al, 2006;Gerlai et al, 2008;Kily et al, 2008;Lopez-Patino et al, 2008a,b;Egan et al, 2009;Fernandes and Gerlai, 2009;Gerlai et al, 2009;MacPhail et al, 2009;Webb et al, 2009;Blaser et al, 2010;Cachat et al, 2010;Irons et al, 2010;Sackerman et al, 2010;Wong et al, 2010;Dlugos et al, 2011;Mathur and Guo, 2011;Maximino et al, 2011), anxiolytics and anxiogenics (Levin et al, 2007;Bencan and Levin, 2008;Bencan et al, 2009;Egan et al, 2009;Lau et al, 2011;Maximino et al, 2011), anti-psychotics (Giacomini et al, 2006;Boehmler et al, 2007), hallucinogens (Swain et al, 2004;Blank et al, 2009;Grossman et al, 2010;Seibt et al, 2010), and sedatives (Zhdanova et al, 2001;Ruuskanen et al, 2005;Renier et al, 2007). Conditioned placed preference testing in adults has been used to identify zeb...…”

Section: Probing Zebrafish Behavior With Small Moleculesmentioning

confidence: 99%

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Behavioral screening for neuroactive drugs in zebrafish

Rihel

Schier

2012

Developmental Neurobiology

110

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The larval zebrafish has emerged asa vertebrate model system amenable to small molecule screens for probing diverse biological pathways. Two large-scale small molecule screens examined the effects of thousands of drugs on larval zebrafish sleep/wake and photomotor response behaviors. Both screens identified hundreds of molecules that altered zebrafish behavior in distinct ways. The behavioral profiles induced by these small molecules enabled the clustering of compounds according to shared phenotypes. This approach identified regulators of sleep/wake behavior and revealed the biological targets for poorly characterized compounds. Behavioral screening for neuroactive small molecules in zebrafish is an attractive complement to in vitro screening efforts, because the complex interactions in the vertebrate brain can only be revealed in vivo.

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Section: Conceptual and Practical Lessonsmentioning

confidence: 80%

Section: Probing Zebrafish Behavior With Small Moleculesmentioning

confidence: 99%

Behavioral screening for neuroactive drugs in zebrafish

Rihel

Schier

2012

Developmental Neurobiology

110

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“…During catalepsy, fish started showing aberrant swimming patterns like an upside down, arrow-like swimming, circular swimming and finally complete the catalepsy as reported by Seibt KJ et al [47].…”

Section: Discussionmentioning

confidence: 56%

Behavioral Studies of Wistar Rats in Rotenone Induced Model of Parkinson’s Disease

Priyanga

Krishnamurthy

Selvaraj

2017

Int J Pharm Pharm Sci

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Objective: The objective of the study was to determine the behavioral activities of Wistar rats induced with rotenone.Methods: Thirty-six male Wistar rats were taken for the study and divided into six groups of six rats each. Group-I is the vehicle-treated, Group-II animals were induced with rotenone (3 mg/kg/bwt) by i. p. Group-III were co-treated with rotenone and L-DOPA (10 mg/kg/bwt) orally, Group-IV were co-treated with rotenone and quercetin (25 mg/kg/bwt) orally, Group-V were co-treated with rotenone and hesperidin (50 mg/kg/bwt) orally, Group-VI were treated with rotenone, quercetin and hesperidin in the same dosage regime for 60 d. The behavioural tests, such as open field test, ladder climbing test and hanging wire test were performed. The biochemical parameters such as urea, creatinine and activities of ALT and AST were also analysed.Results: All data are expressed as the mean±SD. Disability was noted in the behaviour of rats induced with Parkinson's disease (PD). The deficits in behavioral activity were significantly changed when compared with an induced group (p<0.001) and biochemical parameters due to rotenone were significantly (p<0.001) restored by co-treatment with quercetin and hesperidin. Conclusion:In our in vivo study, we have demonstrated the combination of quercetin and hesperidin to serve as neuroprotective compounds by improving the behavioral abnormalities and restoring the biochemical parameters. Hence, these powerful antioxidants may protect brain cells.

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“…The doses of sulpiride and olanzapine used in this study were chosen according to our previous study (Seibt et al 2010). …”

Section: Drug Treatmentsmentioning

confidence: 99%

Investigation into effects of antipsychotics on ectonucleotidase and adenosine deaminase in zebrafish brain

Seibt

Oliveira

Bogo

et al. 2015

Fish Physiol Biochem

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Antipsychotic agents are used for the treatment of psychotic symptoms in patients with several brain disorders, such as schizophrenia. Atypical and typical antipsychotics differ regarding their clinical and side-effects profile. Haloperidol is a representative typical antipsychotic drug and has potent dopamine receptor antagonistic functions; however, atypical antipsychotics have been developed and characterized an important advance in the treatment of schizophrenia and other psychotic disorders. Purine nucleotides and nucleosides, such as ATP and adenosine, constitute a ubiquitous class of extracellular signaling molecules crucial for normal functioning of the nervous system. Indirect findings suggest that changes in the purinergic system, more specifically in adenosinergic activity, could be involved in the pathophysiology of schizophrenia. We investigated the effects of typical and atypical antipsychotics on ectonucleotidase and adenosine deaminase (ADA) activities, followed by an analysis of gene expression patterns in zebrafish brain. Haloperidol treatment (9 µM) was able to decrease ATP hydrolysis (35%), whereas there were no changes in hydrolysis of ADP and AMP in brain membranes after antipsychotic exposure. Adenosine deamination in membrane fractions was inhibited (38%) after haloperidol treatment when compared to the control; however, no changes were observed in ADA soluble fractions after haloperidol exposure. Sulpiride (250 µM) and olanzapine (100 µM) did not alter ectonucleotidase and ADA activities. Haloperidol also led to a decrease in entpd2_mq, entpd3 and adal mRNA transcripts. These findings demonstrate that haloperidol is an inhibitor of NTPDase and ADA activities in zebrafish brain, suggesting that purinergic signaling may also be a target of pharmacological effects promoted by this drug.

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Antipsychotic drugs prevent the motor hyperactivity induced by psychotomimetic MK-801 in zebrafish (Danio rerio)

Cited by 87 publications

References 67 publications

Behavioral screening for neuroactive drugs in zebrafish

Behavioral screening for neuroactive drugs in zebrafish

Behavioral Studies of Wistar Rats in Rotenone Induced Model of Parkinson’s Disease

Investigation into effects of antipsychotics on ectonucleotidase and adenosine deaminase in zebrafish brain

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