Antipsychotic-Like Profile of Alstonine

Lack of pro-convulsant activity of the antipsychotic alkaloid alstonine

“…Differing from most atypical antipsychotics as well as neuroleptics, alstonine does not affect dopamine binding in striatal membranes, indicating lack of direct interaction with dopamine D 1 or D 2 receptors (Costa-Campos et al, 1998). Behavioral experiments indicate a marked anxiolytic property of alstonine, which is not antagonized by the GABA A antagonist picrotoxine (Costa-Campos et al, 2004).…”

“…Behavioral results obtained with alstonine in anxiety experimental models are antagonized by previous administration of ritanserine, indicating the involvement of 5HT 2A/C receptors (Costa-Campos et al, 2004), although alstonine does not interfere with the binding of the 5HT 2A agonist [ 3 H]Spiperone in cortical membranes (Costa-Campos et al, 1998). A differential effect of alstonine in 5HT 2A receptors at cortex and 5HT 2A/C receptors in areas of relevance to anxiety (such as amygdala and septo-hipocampal system) (Hariri et al, 2002) could be the basis for these apparent conflicting results.…”

“…C.O. 's remedy, which exhibits antipsychotic-like properties in several animal models (Costa-Campos et al, 1998). In comparison to antipsychotic medications in clinic, alstonine behaves more like the newer atypical antipsychotic, than the older neuroleptic drugs.…”

A Review on Nootropic Effects of Saptparna

“…Innovative therapeutic strategies comprise of regularization of synaptic dopamine or serotonin levels, serotonin receptor antagonism and modulation of cerebral protein synthesis. [4] An alkaloid from Alstonia scholaris named alstonine shows a clear, dose-dependent (inverted U shape), potent antipsychotic profile [5] in mice models. Alstonine (i.p.)…”

Microwave-Assisted Natural Product Chemistry

“…Lipinska et al have recently reported an ingenious microwave-assisted synthesis of E-ring modified Sempervirine analogues [69] (Scheme 17). Since the first isolation from Gelsenium sempervirens in 1916, Sempervine and its structural analogues have gained considerable synthetic interest due to their impressive range of biological potential [70,71]. Some of the known members of this family such as Flavopereirine, Serpentine and Alstonine exhibit a variety of biological activities, for example anti-HIV, antipsychotic, sedative and immunostimulant activities together with notable cytostatic effects [72].…”