Antipyrene clearance in Indian villagers.

Abstract

1 Antipyrine clearance has been measured using saliva samples in 50 Maharashtrans from a village to the north of Bombay. 2 All subjects were very lean and were also anaemic probably as a result of hookworm infestation. 3 Antipyrine clearance was 36% faster than in White Londoners studied previously and more than twice as fast as in Asian immigrants living in London. 4 Clearance was 25% faster in men than in women but volume of distribution was also greater in men and mean half-lives did not differ significantly between the sexes. 5 There was a negative correlation between antipyrine clearance and haemoglobin concentration. 6 The study has identified geographic differences in antipyrine metabolism which could be clinically important. The role of anaemia merits further study.

Prolongation of antipyrine half‐life after correction of severe anaemia due to hookworm infestation [letter]

“…1), clearance decreased by 18% (P<0.2) and Vd decreased by 4% after correction of the anaemia. The values for Vd and clearance are higher than reported earlier (Desai et al, 1980). In nine patients with initial haemoglobin below 4 g/100 ml T,,2 was increased by 37.25% (P<0.05) while in six patients with a haemoglobin above 4 g/100 ml T,/2 was decreased by 5.6% (P<0.1).…”

“…Pharmac. (I982), 13 population (Desai et al, 1980). This could be due to reduced absorption of antipyrine in our patients.…”

HEPATIC MICROSOMAL ENZYME INDUCTION AND ADRENAL CRISIS DUE TO o,p’DDD THERAPY FOR METASTATIC ADRENOCORTICAL CARCINOMA

“…This finding was reinforced by the demonstration of a reduction in the plasma and salivary half-life of antipyrine, a test which has been considered the reference procedure for revealing microsomal enzyme induction (Goldberg, 1980). Although many environmental factors such as diet, cigarette smoking (Krishnaswamy & Naidu, 1977), drugs (Stevenson, 1977), liver disease, thyroid disease (Park, 1982) and possibly anaemia (Desai et al, 1980) can affect antipyrine half-life, there was no evidence that these were relevant to the changes observed in this patient. It is probable that the cortisol production rate by the tumour on this occasion significantly exceeded the capacity of the induced liver enzymes for cortisol degradation; thus adrenal insufficiency was never provoked.…”

Differences in Drug Pharmacokinetics Between East Asians and Caucasians and the Role of Genetic Polymorphisms

“…Potential factors for the variability in drug pharmacokinetics and pharmacodynamics include food, drug interactions, body weight, gender, age, genetics, disease states of patients, and lifestyle variables (smoking and alcohol consumption), which may correlate with one another. Among these, various environmental factors (diet, nutrition, climate, lifestyle, and health) and cultural differences in attitudes toward the disorder are considered to be very substantial 1–11 . Climate influences food product and, therefore, is a factor determining the ethnic features of nutrition.…”