Antipyretic Activity of Acetylsalicylic Acid and Salicylamide Suspension in Pediatrics

Borovsky, Maxwell P.

doi:10.1001/archpedi.1960.04020040025007

Cited by 14 publications

(5 citation statements)

References 6 publications

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“…Both the absolute (reduction of initial fever) and relative (in comparison with paracetamol or other drugs) antipyretic efficacy of ASA in febrile children have been extensively evaluated [15,18,19,24,41,55,57,68,80,82,[106][107][108]122].…”

Section: Clinical Resultsmentioning

confidence: 99%

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Treatment of fever in childhood

Adam

Stankov

1994

Eur J Pediatr

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Although the need for routine antipyretic therapy in children has often been questioned, there are no data to contra-indicate this. Not all fevers need to be treated but many physicians do so to relieve parental concern. The most commonly used antipyretic drugs are acetylsalicylic acid (ASA), paracetamol (acetaminophen) and dipyrone (metamizol). Paracetamol and ASA have been extensively evaluated but there are few clinical trials on dipyrone. In the last decade a strong statistical association has been observed between salicylates and Reye syndrome. Paracetamol is the most common cause of acute hepatic failure. Dipyrone has been associated with agranulocytosis. In the light of these findings the extensive use of antipyretics drugs has been seriously questioned.

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Section: Clinical Resultsmentioning

confidence: 99%

“…The antipyretic efficacy of paracetamol in febrile children has been documented in numerous trials [15,24,50,55,57,63,80,107,108,111,120]. It is comparable with ASA in having a similar onset, peak effect and duration of antipyresis.…”

Section: Clinical Resultsmentioning

confidence: 99%

Treatment of fever in childhood

Adam

Stankov

1994

Eur J Pediatr

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“…Salicylamide has analgesic, antipyretic, and hypnotic activities (1-3) but its clinical effectiveness is limited (4)(5)(6) due to extensive presystemic biotransformation after oral administration (7,8). The drug is, however, a valuable research tool for the exploration of drug conjugation reactions (9, lo), drug absorption (11)(12)(13)(14) and metabolism interactions (15,161, route of administration effects on drug disposition (17,18), effects of disease on drug disposition (19-21), drug concentration-effect relationships (22), product inhibition (231, fetal development (241, and the clinical assessment of metabolic immaturity and disorders (25)(26)(27).…”

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confidence: 99%

Determination of Salicylamide and Five Metabolites in Biological Fluids by High-Performance Liquid Chromatography

Morris

Levy

1983

Journal of Pharmaceutical Sciences

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“…However, because of a lack of clear-cut, objective clinical evidence, support for these indications has not been well established in the literature (2,3,14,16). A hypothesis to explain the apparent relatively poor clinical performance of salicylamide is based on the poor watersolubility of the compound as formulated.…”

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confidence: 99%

Hypnotic Effectiveness of Sodium Salicylamide with Short-Term Use: Sleep Laboratory Studies

Soldatos

Kales

Bixler³

et al. 1978

Pharmacology

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Sodium salicylamide in doses of 650 and 1,300 mg was evaluated in two separate sleep laboratory drug evaluation studies of insomniac patients. Each study utilized a standard protocol of 10 consecutive laboratory nights consisting of four placebo nights for adaptation and baseline, three drug nights for short-term drug administration and three placebo nights for evaluating withdrawal. Neither dose had a clear-cut hypnotic effect in inducing or maintaining sleep. Sleep stages were not affected by drug administration or drug withdrawal. Both the objective findings and subjective estimates suggest that the 1,300-mg dose may have a slight sedative effect. However, when salicylamide is used as an ingredient in over-the-counter preparations, the usual dose is only 200–400 mg.

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Antipyretic Activity of Acetylsalicylic Acid and Salicylamide Suspension in Pediatrics

Cited by 14 publications

References 6 publications

Treatment of fever in childhood

Treatment of fever in childhood

Determination of Salicylamide and Five Metabolites in Biological Fluids by High-Performance Liquid Chromatography

Hypnotic Effectiveness of Sodium Salicylamide with Short-Term Use: Sleep Laboratory Studies

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