Antipyretic and Analgesic Effects of the Aqueous Extract of the Fruit Pulp of Hunteria umbellata K Schum (Apocynaceae)

Igbe, Ighodaro; Ozolua, Raymond I.; Okpo, SO; Obasuyi, Osahon

doi:10.4314/tjpr.v8i4.45226

Cited by 33 publications

(21 citation statements)

References 10 publications

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“…The initiation, manifestations, and regulation of the febrile response are dependent on the pyrogenic and antipyrogenic properties of various exogenous and endogenous substances. There is a general consensus that fever is caused by regular rise in body temperature above normal daily fluctuations originating in conjunction with an elevated thermoregulatory set point (Igbe et al ., ; Ogoina, ). These neurons are sensitive not only to changes in blood temperature but also to cold and warm receptors located in skin and muscle and thus maintain an appropriate balance between the heat production and loss (Taniguchi et al ., ; Zhu et al ., ).…”

Section: Discussionmentioning

confidence: 98%

Antipyretic and Anticonvulsant Activity of Polygonatum verticillatum: Comparison of Rhizomes and Aerial Parts

Khan

Saeed

Gilani

et al. 2012

Phytotherapy Research

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The current study was undertaken to explore the antipyretic and anticonvulsant profile of the Polygonatum verticillatum in established pharmacological paradigms. The crude methanol extract of rhizomes (PR) and aerial parts (PA) of the plant were tested in Brewer's-yeast-induced pyrexia and pentylenetetrazole-induced convulsion test. PR and PA both evoked prominent antipyretic activity (p < 0.01) in a dose-dependent manner during all assessment times at the dose of 50, 100, and 200 mg/kg intraperitoneally. The protection elicited by PR (82.20%) at 200 mg/kg was comparable with aspirin (88.48%) as a standard drug at 100 mg/kg. However, PA was less potent, and maximum protection was 64% at 200 mg/kg. Both PR and PA were devoid of any anticonvulsant activity. Our results demonstrated prominent evidence of antipyretic activity of P. verticillatum that is consistent with the folk uses of the plant. In addition from a biodiversity point of view, PA of the plant can also be used as an alternate of PR.

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Section: Discussionmentioning

confidence: 98%

Antipyretic and Anticonvulsant Activity of Polygonatum verticillatum: Comparison of Rhizomes and Aerial Parts

Khan

Saeed

Gilani

et al. 2012

Phytotherapy Research

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“…The extracts of Lindernia crustacea showed significant antipyretic effect against the pyrexia induced by Brewer's yeast. The possible mechanism for the antipyretic activity of extracts may be due to the inhibition of PGE2 synthesis 36,37 . The antipyretic activity may be due to flavonoids or phenolic compounds found in the extracts.…”

Section: Discussionmentioning

confidence: 99%

Scientific Evidence of Lindernia Crustacea (L) F.MUELL, an Indigenous Plant: A Folklore Medicine Used Traditionally

Das¹,

Ahmed²,

Saha³

et al. 2019

Int. Res. J. Pharm.

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Lindernia crustacea (L) F.Muell is one of the commonest plants used as a medicinal plant in India, Indonesia and Malaysia. There is no scientific evidence on the pharmacological activity of this plant.The aim of this study is to determine anti-inflammatory, analgesic and antipyretic activities of various extracts of Lindernia crustacea using different models of rodents. The method of the study consisted of extraction, phytochemical screening, toxicity study, anti-inflammatory, analgesic and antipyretic activities. Flavonoid and phenolic compound were found to be present in all three extracts.The pharmacological screening results showed that all three extracts showed activities at the dose of 200mg/kg, but among the extracts, benzene extract showed more significant anti-inflammatory, analgesic and antipyretic activity. From the findings of the above study, it may be concluded that aerial part extracts of Lindernia crustacea possess significant anti-inflammatory, analgesic and antipyretic activities.

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“…21,22,23 The inhibition of prostaglandin synthesis could be the possible mechanism of antipyretic action as that of paracetamol and the inhibition of prostaglandin can be achieved by blocking the cyclooxygenase enzyme activity. 24,25,12 The antipyretic effect of BEAF may be due to inhibiting the enzyme cyclooxygenase and reducing the level of prostaglandin within the hypothalamus in pyrexia rats. Phytochemical study of the whole plant Atractylis flava showed abundance of flavonoids triterpenes, steroids, and saponins.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory, Anti-pyretic and Acute Toxicity Effects of n-Butanol Extract of Atractylis flava Desf in Rats

Akram¹,

Benkiki²,

Eddine³

et al. 2018

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Objectives:This study was aimed to explore the antipyretic and anti-inflammatory effects of n-butanol etract of Atractylis flava Desf (A. flava) using experimentally induced inflammation and pyrexia models in rats. Methods: In the acute toxicity study, a single oral dose of 2000 mg/kg of n-butanol extract was given to rats. The antipyretic activity was evaluated using brewer's yeast induced pyrexia in rats. In addition, albumin induced rat paw edema was performed by the injection of 100 µL undiluted fresh egg albumin to assess the anti-inflammatory effects of the plant. Results: The results of the present study revealed that n-butanol extract of A. flava significantly (P<0.001) reduced fresh egg albumin-induced rat paw edema and also inhibited fever significantly in brewer's yeast induced pyrexia. Conclusion: The results of the present study indicated that A. flava possesses antipyretic and anti-inflammatory activity in the models studied.

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Antipyretic and Analgesic Effects of the Aqueous Extract of the Fruit Pulp of Hunteria umbellata K Schum (Apocynaceae)

Cited by 33 publications

References 10 publications

Antipyretic and Anticonvulsant Activity of Polygonatum verticillatum: Comparison of Rhizomes and Aerial Parts

Antipyretic and Anticonvulsant Activity of Polygonatum verticillatum: Comparison of Rhizomes and Aerial Parts

Scientific Evidence of Lindernia Crustacea (L) F.MUELL, an Indigenous Plant: A Folklore Medicine Used Traditionally

Anti-Inflammatory, Anti-pyretic and Acute Toxicity Effects of n-Butanol Extract of Atractylis flava Desf in Rats

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