Antipyretic and anticonvulsant activity of n-hexane fraction of Viola betonicifolia

Muhammad, Naveed; Saeed, Muhammad; Khan, Haroon; Raziq, Naila; Halimi, Syed Muhammad Ashhad

doi:10.1016/s2221-1691(13)60063-5

Cited by 11 publications

(7 citation statements)

References 11 publications

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“…Muhammad et al, [51] reported the antipyretic effect of the n -hexane fraction of V. betonicifolia whole-plant induced by yeast in mice. The antipyretic effect of n -hexane fraction of V. betonicifolia (300 mg/kg) started from the 1st h and remained significant up to the 5th h post-treatment, while at a dose of 200 mg/kg, the antipyretic effect started after the 2nd h of treatment and remained significant up to the 5th h. A weaker antipyretic effect at the dose of 100 mg/kg was also observed.…”

Section: Pharmaceutical Potential Of Viola Betonicifoliamentioning

confidence: 99%

“…The n -hexane fraction of V. betonicifolia were exhibited the supreme effect which was (400 and 500 mg/kg), as the latency time for the general clonic-tonic seizure (fifth phase) was augmented up to 25.3 min. After 24 h, the n -hexane fraction of V. betonicifolia did not cause mortality at any tested dosage level, but it did not reveal protection in the strychnine-induced anticonvulsant test at different doses of 300, 400, and 500 mg/kg i.p., and the mice ultimately died [51].…”

Section: Pharmaceutical Potential Of Viola Betonicifoliamentioning

confidence: 99%

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A Comprehensive Review on Chemical and Pharmacological Potential of Viola betonicifolia: A Plant with Multiple Benefits

et al. 2019

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Viola betonicifolia (Violaceae) is commonly recognized as “Banafsha” and widely distributed throughout the globe. This plant is of great interest because of its traditional, pharmacological uses. This review mainly emphases on morphology, nutritional composition, and several therapeutic uses, along with pharmacological properties of different parts of this multipurpose plant. Different vegetative parts of this plant (roots, leaves, petioles, and flowers) contained a good profile of essential micro- and macronutrients and are rich source of fat, protein, carbohydrates, and vitamin C. The plant is well known for its pharmacological properties, e.g., antioxidant, antihelminthic, antidepressant, anti-inflammatory, analgesic, and has been reported in the treatment of various neurological diseases. This plant is of high economic value. The plant has potential role in cosmetic industry. This review suggests that V. betonicifolia is a promising source of pharmaceutical agents. This plant is also of significance as ornamental plant, however further studies needed to explore its phytoconstituents and their pharmacological potential. Furthermore, clinical studies are needed to use this plant for benefits of human beings.

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Section: Pharmaceutical Potential Of Viola Betonicifoliamentioning

confidence: 99%

Section: Pharmaceutical Potential Of Viola Betonicifoliamentioning

confidence: 99%

A Comprehensive Review on Chemical and Pharmacological Potential of Viola betonicifolia: A Plant with Multiple Benefits

et al. 2019

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“…After the respective treatment, the rectal temperature of each animal was again recorded at 1 h intervals for following 5 h. The obtained data were used for the calculation of percentage reduction in rectal temperature. Antipyretic activity was defined as the efficacy of test drug to abate the induced-pyrexia (Muhammad et al 2013 ). where A is the normal body temperature, B is the temperature after pyrexia induction, C is the temperature after 1, 3 and 5 h.…”

Section: Methodsmentioning

confidence: 99%

Emerging CAM Ziziphus nummularia with in vivo sedative-hypnotic, antipyretic and analgesic attributes

et al. 2016

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Ziziphus nummularia from Rhamnaceae family is traditionally used for sedative-hypnotic, antipyretic and analgesic purposes; however, scientific validations are lacking. This in vivo study was undertaken to verify the above ameliorative properties of Z. nummularia root methanolic extract. Various fractions of the extract were assayed on Balb/c mice by open field, Brewer’s yeast-induced hyperthermia and acetic acid-induced writhing experiments. The significance of the outcomes was analyzed with statistical tests. Various fractions of the extract exhibited marked dose-dependent (p < 0.05) sedative-hypnotic and antipyretic activities. The biological efficacies were most pronounced between 50 and 100 mg/kg. Further, the acetic acid-induced abdominal constrictions were significantly (p < 0.05) attenuated by the extract. Chloroform fraction of the extract was most dominant followed by ethyl acetate. The demonstrated therapeutic attributes of Z. nummularia extract can be exploited to isolate pharmaceutically relevant compounds.

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“…After drug administration, the rectal temperature was once more noted periodically at 1, 2, 3, 4, and 5 h of drug administration. The percent effect was calculated using our previous formula (Muhammad et al, 2013).…”

Section: Yeast Induced Antipyretic Activitymentioning

confidence: 99%

Gastrointestinal Motility, Muscle Relaxation, Antipyretic and Acute Toxicity Screening of Amyrin Type Triterpenoid (Daturaolone) Isolated From Datura metel Linnaeus (Angel’s Trumpet) Fruits

Rauf

Bawazeer

2020

Front. Pharmacol.

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Datura metel Linn is used traditionally for the treatment of various diseases including relaxation of smooth muscles, relief of fever, as well as gastrointestinal disorder. This study deals with the bio-guided isolation of an active, amyrin-type triterpenoid, namely 3-oxo-6b-hydroxy-b-amyrin (daturaolone; 1), from the chloroform fraction of Datura metel L. (Angel's trumpet) fruits and its gastrointestinal motility, antipyretic, and muscle relaxation effects in animal models. The chemical structure of daturaolone (1) was elucidated by NMR spectroscopy and crystallography techniques. The chloroform fraction and daturaolone (1) were assessed for the GIT motility test. Data exhibited in charcoal meal GI transit test show that chloroform fraction and daturaolone (1) significantly reduce GIT motility and increased intestinal transit time, comparable to the standard (atropine), a muscarinic receptor blocking agent. Muscle relaxant potency of the extract and daturaolone (1) was assessed in various animal paradigms. In the inclined plane screening test, it produced a significant (P < 0.05) muscle relaxation potential in a dose-dependent manner after 30, 60, and 90 min. Likewise, the muscle relaxation potential of the extract and daturaolone (1) was strongly complemented by the chimney and traction test, representing a dominant effect after 60 min of sample administration. The chloroform fraction showed good antipyretic activity, and while daturaolone (1) exhibited significant activity at a higher dose, the maximum effect (84.64%) was at 20 mg/kg i.p. In acute toxicity screening test, the chloroform extract (100, 250, 500, and 1,000 mg/kg) and daturaolone (1) (5, 10, 20, and 50 mg/kg) were found safe. In conclusion, the chloroform extract and daturaolone (1) exhibited strong gastrointestinal motility, muscle relaxation, and antipyretic activity in different animal models and intestinally, was found safe at higher tested doses.

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Antipyretic and anticonvulsant activity of n-hexane fraction of Viola betonicifolia

Cited by 11 publications

References 11 publications

A Comprehensive Review on Chemical and Pharmacological Potential of Viola betonicifolia: A Plant with Multiple Benefits

A Comprehensive Review on Chemical and Pharmacological Potential of Viola betonicifolia: A Plant with Multiple Benefits

Emerging CAM Ziziphus nummularia with in vivo sedative-hypnotic, antipyretic and analgesic attributes

Gastrointestinal Motility, Muscle Relaxation, Antipyretic and Acute Toxicity Screening of Amyrin Type Triterpenoid (Daturaolone) Isolated From Datura metel Linnaeus (Angel’s Trumpet) Fruits

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