Emerging CAM Ziziphus nummularia with in vivo sedative-hypnotic, antipyretic and analgesic attributes

Ali, Jawad; Khan, Haroon; Mubarak, Mohammad S.; Patel, Seema

doi:10.1007/s13205-015-0322-5

Cited by 21 publications

(19 citation statements)

References 60 publications

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“…The phenolics, flavonoids, and triterpenic saponins are among the active components of jujube [23,31,32]. The triterpenic saponins may be useful for lightening of sleep disorders through the modulation of [23,31,33,34]. In a clinical trial that evaluate the usefulness of sour date (Zizyphus jujube var.…”

Section: Discussionmentioning

confidence: 99%

Investigation the Effect of Jujube Capsule on Sleep Quality of Postmenopausal Women: A Double-blind Randomized Clinical Trial

Mahmoudi¹,

Ansari²,

Haghighizadeh³

et al. 2020

BioMedicine

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Bakground and objective: Sleep disorder is among the most common problems in the life of postmenopausal women. Because of the complications of chemical drugs, many women prefer to use herbal supplements for relieving sleep problems. So, the main objective of this study was to determine the effect of the jujube seed capsule on sleep quality in postmenopausal women. Materials and methods: This study was a double-blind clinical trial conducted on 106 postmenopausal women in Khuzestan province, southwest of Iran. All participants were selected by a simple non-probability sampling method. Data were collected through a demographic data form and the Pittsburgh sleeps quality index (PSQI). Individuals were randomly divided into intervention (n ¼ 53) and control (n ¼ 53) groups. The intervention group received 250 mg oral jujube seed capsule and the control group received a placebo capsule twice a day for 21 days. After the treatment, the PSQI was completed in both intervention and control groups. Data were analyzed using the independent t-test and the Chi-square test using SPSS software version 24, and p-value < 0.05 was considered as the significance level. Results: The results revealed that after treatment, the mean scores of sleep quality decreased in the intervention and control group. Although this difference was statistically significant in both intervention and control groups (pvalue < 0.05), more reduction observed in the intervention group (p-value < 0.001). Conclusion: Consumption of the jujube seed capsule had a positive impact on improving the sleep quality of postmenopausal women and could be recommended as a useful herbal medication.

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Section: Discussionmentioning

confidence: 99%

Investigation the Effect of Jujube Capsule on Sleep Quality of Postmenopausal Women: A Double-blind Randomized Clinical Trial

Mahmoudi¹,

Ansari²,

Haghighizadeh³

et al. 2020

BioMedicine

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“…Thirty minutes after vehicle or HEPP and 15 minutes after diazepam treatment, TS was administered to each animal intraperitoneally (ip) at dose of 20‐mg/kg bodyweight. Then, the animals were observed for the time to lose their righting reflex, immediately after thiopental injection and duration of sleep induced by TS …”

Section: Methodsmentioning

confidence: 99%

“…Then, the animals were observed for the time to lose their righting reflex, immediately after thiopental injection and duration of sleep induced by TS. 18,19 2.7 | Barbiturate-induced sleeping time All the animals were divided into five groups (n = 6); the control group was treated with normal saline (10 mL/kg); the reference group was treated with standard drug diazepam (4 mg/kg), and remaining three groups were treated with HEPP of different concentrations of three doses such as 200, 400, and 600-mg/kg bodyweight. These treatments were carried out 30 minutes before challenging the animals with ip injection of phenobarbitone at dose of 40-mg/kg body weight.…”

Section: Thiopental-induced Sleeping Timementioning

confidence: 99%

Pharmacological basis for sedative and hypnotic like effects of Pyrus pashia using in vivo experimental models

Ain

Khan

2019

Int J Geriat Psychiatry

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Objective Pyrus pashia has traditionally been used as a therapeutic agent including sedative. In this regard, hydroethanolic extract of Pyrus pashia (HEPP) was screened for phytochemical investigation, acute toxicity, and sedative‐hypnotic activity to provide a scientific rationale to its ethno‐medicinal uses. Methods Mice were used in acute toxicity test; sedative potential was observed in open field test while thiopental‐induced sleeping time and barbiturate‐induced sleeping time tests were used for the assessment of hypnotic like effects of HEPP. Various phytochemical groups were detected in preliminary phytochemical tests. Results In acute toxicity study, the extract was found safe up to 1g/kg while the extract caused 50% death at 1500 mg/kg. In all animal models, the extract had shown sedative and hypnotic effects but the most significant effect observed at increased dose in comparison with standard diazepam‐treated group. In open field test, the extract at doses of 200 and 400 mg/kg, there is mild decrease in number of lines crossed by tested animals (mice) while significant reduction shown at 600 mg/kg compared with diazepam‐treated group at dose 0.5 mg/kg. In phytochemical investigation HEPP subjected to different phytochemical tests. From the thoroughly study, it is revealed that these constituents mainly participating in sedation and hypnosis. Conclusions The results of the present study showed significant sedative‐hypnotic effects of the HEPP in mice and that the central benzodiazepine receptors are involved in the sedative‐hypnotic effects of this plant.

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“…Rauf A et al, (2016), evaluated the methanolic extract of Zizyphus nummularia roots for sedative-hypnotic, antipyretic and analgesic properties. Marked dose-dependent (p\0.05) sedative hypnotic, analgesic and antipyretic activities was exhibited by various extracts at dose 50 and 100 mg/kg [31].…”

Section: Sedative and Hypnotic Activitymentioning

confidence: 99%

Ethanobotanical, phytochemical and pharmacological properties of Zizyphus nummularia (Burm. F.): A Review

Aggarwal¹,

Sharma²,

Lamba³

2018

ijpm

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Zizyphus nummularia (Burm. F.), Family: Rhamnaceae, is widely distributed in dry regions of India. It is a bushy weed used as folk medicine. The plant is valued for its nutritional edible fruits. Traditionally, it is used in mental retardation, fever, diarrhea, dysentery. The plant has been evaluated for various pharmacological activities such as anti-inflammatory, anthelmintic, antibacterial, antifertility activity. Present review discusses phytochemistry and pharmacological aspects of the drug.

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Emerging CAM Ziziphus nummularia with in vivo sedative-hypnotic, antipyretic and analgesic attributes

Cited by 21 publications

References 60 publications

Investigation the Effect of Jujube Capsule on Sleep Quality of Postmenopausal Women: A Double-blind Randomized Clinical Trial

Investigation the Effect of Jujube Capsule on Sleep Quality of Postmenopausal Women: A Double-blind Randomized Clinical Trial

Pharmacological basis for sedative and hypnotic like effects of Pyrus pashia using in vivo experimental models

Ethanobotanical, phytochemical and pharmacological properties of <em>Zizyphus nummularia</em> (Burm. F.): A Review

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