“…Indeed, the antipyretic activity of Vitex trifolia seeds has been reported in rabbits (Ikram et al, 1987). This effect must be related to the presently demonstrated inhibitory effect of Vitex trifolia aqueous extract on the synthesis or release of IL-1 and IL-6 which are involved in the regulation of the body temperature and known as pyrogenic cytokines (Elenkov et al, 2005).…”