Antiradical and antioxidant activity of flavones fromScutellariae baicalensis radix

Abstract

We evaluated the antioxidant properties of four main flavones from Scutellaria baicalensis: baicalein, wogonin and their glucuronides - baicalin and wogonoside. We used three in vitro assays: free radical scavenging with 2,2'-diphenylpicrylhydrazyl radical, transition metal ions reducing power by phosphomolybdenum assay and inhibition of the hydroxyl radical-induced peroxidation of linoleic acid assay. All flavones have antioxidant capacity, which differs depending on the structure and mechanisms of activity. In all tests, only baicalein - the aglycone with three adjacent hydroxyl groups - exhibited consistent antioxidant effect. Wogonin protected linoleic acid against oxidation. Baicalin displayed less potent antioxidant properties whereas wogonoside did not have significant antioxidant activity.

The Relationship Between Endogenous β‐Glucuronidase Activity and Biologically Active Flavones‐Aglycone Contents in Hairy Roots of Baikal Skullcap

“…Despite similar structure of these four flavones, there are some differences in the manifestation degree of their physiological activity. As a whole, aglycone forms, especially baicalein, exhibit high antioxidant activity . Moreover, their antiviral activity and, more importantly, antitumor activity has also been studied.…”

“…As a whole, aglycone forms, especially baicalein, exhibit high antioxidant activity. [8] [9] Moreover, their antiviral activity [10] [11] and, more importantly, antitumor activity has also been studied. Major flavones of the skullcap roots not only suppress the growth of the tumor cells themselves, but enhance the antitumor activity of other medications at the combined administration.…”

Effect of the Lipoxygenase Inhibitor Baicalein on Muscles in Ovariectomized Rats

“…It acts as a lipoxygenase (especially cyclooxygenase (COX-I) inhibitor) and is also a potent inhibitor to 12-lipoxygenase (12-LOX) and 15-LOX and, therefore, has an antioxidative effect [24–27]. Furthermore, it inhibits nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κ B) and suppresses the function of tumor necrosis factor-alpha 8 (TNF- α ) and/or IL-6, all of them being mediators of inflammation cascades.…”

Baicalein attenuates hypertrophic scar formation via inhibition of the transforming growth factor‐β/Smad2/3 signalling pathway

“…[13][14][15] Baicalein, or 5,6,7-trihydroxyflavone, is a type of flavonoid originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. This compound has been shown to possess a variety of biological characteristics, including antioxidative 16 and anti-inflammatory effects, 17 tumour growth inhibition 18 and protection of ischaemia/reperfusion injury. 19 It has been proven to attenuate fibrotic activities in cardiac fibroblasts via mitogen-activated protein kinase signalling 20 and to suppress hepatic stellate cell migration by inhibiting monocyte chemoattractant protein-1 expression.…”