Antiretroviral treatment response of HIV‐infected children after prevention of mother‐to‐child transmission in West Africa

Ndondoki, Camille; Dicko, Fatoumata; Coffie, Patrick A.; Eboua, Tanoh Kassi François; Ekouévi, Didier K.; Kouadio, Kouakou; Aka, Addi Edmond; Malateste, Karen; Dabis, François; Amani-Bossé, Clarisse; Touré, P; Leroy, Valériane

doi:10.7448/ias.17.1.18737

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…18 About 66.7% anemia occurred in HEI infants in this study. Anemia could be correlated with several factors as described in several previous studies such as advanced clinical and immunological HIV disease stage 19,20 , breastfeeding period 21 , highly active antiretroviral therapy (HAART), and cotrimoxazole. 7 Further research is needed to determine the cause of anemia in this group.…”

Section: Incidence Of Anemia: Anemia Has Been Recognizedmentioning

confidence: 75%

The Outcomes of Infants with HIV Infected Mother in a Tertiary Hospital in Indonesia

Ningtiar¹,

Kartina²,

Puspitasari³

et al. 2019

Ind. Jour. of Publ. Health Rese. & Develop.

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Background: Infant from HIV mother face the risk of HIV infection. Effective prevention on mother-tochild transmission (PMTCT) program increasing the number of uninfected infants in East Java Indonesia. This study describes the outcomes of infants with HIV mother in Dr. Soetomo Hospital, a tertiary referral hospital in East Java, related to outcome (infectious morbidity, nutritional status, immunodeficiency status, growth/development, and incidence of anemia). Method:This cross-sectional study analyzed 0-18 months infant and HIV mother pairs at HIV outpatient clinic Dr. Soetomo General Hospital from January to April 2017. The data were collected and analyzed using Fisher's exact test and chi-square test with P<0.05.Results: Fourty HIV-infected mothers and infants pairs were analyzed, separated into two groups positive (3 infants) and negative (37 infants) Anti HIV PCR. There were 19 male. Age distribution (6 weeks-5 months 40%; 6-11 months 47.5%; 12-18 months 12.5%). Five percent were born prematurely, 77.5% infant has normal birth-weight. Only 2.5% were fed breast milk, AZT-cotrimoxazole were given to 87.5% infant while the rest received AZT/3TC/NVP. Immunizations of the infants were mostly (60%) up to date. Infectious morbidity (P=0.433), WAZ-score (P=0.666), LAZ-score (P=0,973), WLZ-score (P=0.219) and incidence of anemia (P=0.548) were not significant differences between groups. The development test using DDST II (P=0,001), as well as immunodeficiency status [presence of immunodeficiency (P<0.001)] was significantly different between groups. conclusion: There were significant effects of HIV exposed on the development and immunodeficiency status in 0-18 months infant.

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Section: Incidence Of Anemia: Anemia Has Been Recognizedmentioning

confidence: 75%

The Outcomes of Infants with HIV Infected Mother in a Tertiary Hospital in Indonesia

Ningtiar¹,

Kartina²,

Puspitasari³

et al. 2019

Ind. Jour. of Publ. Health Rese. & Develop.

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“…In most studies, the virologic response is assessed during the rst two years following ART initiation of HIV-infected infants (7)(8)(9)(10)12,(21)(22)(23)(24)(25)(26)(27)(28). However, early initiation of ART in vertically HIV-infected children exposes them to a very long-lasting treatment relative to that of adults.…”

Section: Introductionmentioning

confidence: 99%

Long-term outcomes of early initiated antiretroviral therapy in sub-Saharan children: A Cameroonian cohort study

Ndongo

Tejiokem

Penda

et al. 2020

Preprint

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Background: In most studies, the virological response is assessed during the first two years of antiretroviral treatment initiated in HIV-infected infants. However, early initiation of antiretroviral therapy exposes infants to very long-lasting treatment. Moreover, maintaining viral suppression in children is difficult. We aimed to assess the virologic response and mortality in HIV-infected children after five years of early initiated antiretroviral treatment (ART) and identify factors associated with virologic success in Cameroon. Methods: In this cohort study, we included 149 children who were still alive after two years of early ART. Virologic response was assessed after 5 years of treatment. The probability of maintaining virologic success between two and five years of ART was estimated using Kaplan-Meier curve. Factors associated with a viral load < 400 copies/mL in children still alive at five years of ART were studied using logistic regressions.Results: The viral load after five years of early ART was suppressed in 66.8% (60.1 - 73.5) of the 144 children still alive and in care. Among the children with viral suppression after two years of ART, the probability of maintaining viral suppression after five years of ART was 64.0% (54.0 - 74.0). The only factor associated with viral suppression after five years of ART was achievement of confirmed virological success within the first two years of ART (OR = 2.7 (1.1-6.8); p = 0.033).Conclusions: This study reported difficulty in maintaining virologic success in sub-Saharan HIV-infected children between two and five years of early initiated ART. It also highlighted the importance of initial viral suppression for achieving and maintaining virologic success in the long-term.

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“…In most studies, the virologic response is assessed during the first two years following ART initiation of HIVinfected infants (7)(8)(9)(10)12,(21)(22)(23)(24)(25)(26)(27)(28). However, early initiation of ART in vertically HIV-infected children exposes them to a very long-lasting treatment relative to that of adults.…”

Section: Introductionmentioning

confidence: 99%

Long-term outcomes of early initiated antiretroviral therapy in sub-Saharan children: A Cameroonian cohort study

Ndongo¹,

Tejiokem²,

Penda³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background In most studies, the virological response is assessed during the first two years of antiretroviral treatment initiated in HIV-infected infants. However, early initiation of antiretroviral therapy exposes infants to very long-lasting treatment. Moreover, maintaining viral suppression in children is difficult. We aimed to assess the virologic response and mortality in HIV-infected children after five years of early initiated antiretroviral treatment (ART) and identify factors associated with virologic success in Cameroon. Methods In this cohort study, we included 149 children who were still alive after two years of early ART. Virologic response was assessed after 5 years of treatment. The probability of maintaining virologic success between two and five years of ART was estimated using Kaplan-Meier curve. Factors associated with a viral load < 400 copies/mL in children still alive at five years of ART were studied using logistic regressions. Results The viral load after five years of early ART was suppressed in 66.8% [60.1–73.5] of the 144 children still alive and in care. Among the children with viral suppression after two years of ART, the probability of maintaining viral suppression after five years of ART was 64.0% [54.0–74.0]. The only factor associated with viral suppression after five years of ART was achievement of confirmed virological success within the first two years of ART [OR = 2.7 (1.1–6.8); p = 0.033]. Conclusions This study reported difficulty in maintaining virologic success in sub-Saharan HIV-infected children between two and five years of early initiated ART. It also highlighted the importance of initial viral suppression for achieving and maintaining virologic success in the long-term.

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Antiretroviral treatment response of HIV‐infected children after prevention of mother‐to‐child transmission in West Africa

Cited by 5 publications

References 35 publications

The Outcomes of Infants with HIV Infected Mother in a Tertiary Hospital in Indonesia

The Outcomes of Infants with HIV Infected Mother in a Tertiary Hospital in Indonesia

Long-term outcomes of early initiated antiretroviral therapy in sub-Saharan children: A Cameroonian cohort study

Long-term outcomes of early initiated antiretroviral therapy in sub-Saharan children: A Cameroonian cohort study

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