Antiseptic Nanocapsule Formation via Controlling Polymer Deposition onto Water‐in‐Oil Miniemulsion Droplets

Abstract

Summary:The stable nanodroplet was prepared by inverse miniemulsion with an aqueous antiseptic solution dispersed in an organic medium of solvent/nonsolvent mixture containing an oil-soluble surfactant and the polymer for shell formation. The change in gradient of the solvent/nonsolvent mixture, obtained by heating at 50 8C, led to the precipitation of the polymer in the organic phase and deposition onto the large interphase of the aqueous miniemulsion droplets. The monodisperse polymer nanocapsule, with the size range of 80-240 nm, dispersed in cyclohexane phase was achieved as a function of surfactant concentration. By variation of polymer content, molecular weight and type, an encapsulation efficiency of 20-100% was obtained as detected by proton-nuclear magnetic resonance spectroscopy measurement. The nanocapsule could be easily transferred into water as continuous phase resulting in aqueous dispersion with nanocapsule containing the antiseptic agent as an aqueous core. The encapsulated amount of the antiseptic agent was evaluated to indicate the durability of the nanocapsule's wall. Additionally, the different types of polymer having glass transition temperature ranging from À60 to 1008C have been successfully used. Currently, the research work on the incorporation of nanocapsules onto natural rubber (NR) latex in order to prepare NR latex glove containing the antiseptic agent nanocapsules is carried out. By using the simple and versatile layer-by-layer (LbL) technique based mainly on an electrostatic interaction between oppositely charged species, the deposition of nanocapsules onto NR latex film has successfully been fulfilled.

Gold nanoparticle-enhanced luminescence of silicon quantum dots co-encapsulated in polymer nanoparticles

“…When considering synthetic approaches to nanocomposite materials, miniemulsion polymerization has been reported as a convenient and powerful technique to encapsulate a range of different type of materials, including organic and inorganic nanoparticles [33][34][35][36][37][38][39][40] inside polymeric nanoparticles. [41][42][43][44][45][46][47][48] Encapsulation of inorganic species inside polymer matrices affords composite materials which benet from the outstanding properties associated with synthetic polymers e.g. their excellent mechanical, chemical, electrical, rheological, magnetic and optical properties.…”

Surveillance of prophylactic mastectomy

“…The layer‐by‐layer (LbL) self‐assembly of polyelectrolytes (PE) is acknowledged as a convenient and versatile method to obtain the polymeric microcapsules based on the dissolvable colloidal templates. Therefore, the nanoencapsulation could be achieved by the assembly of the PE deposited on the surface of the colloidal particles (silica,4 CaCO 3 ,5 polystyrene latex,6 Au,7 and melamine formaldehyde particles8) or droplets,9 and then the templates were dissolved or etched to obtain the hollow shells, which could be refilled with the desired molecules. However, the main disadvantage of this method is the low efficiency of loading of the active substances into the capsules because of the fact that the active substances could only be adsorbed on the capsule walls rather than being loaded into the hollow cavum of the capsules 6.…”

Synthesis of biocompatible and thermally sensitive poly(N‐vinylcaprolactam) nanogels via inverse miniemulsion polymerization: Effect of the surfactant concentration

“…When compared with direct miniemulsion polymerization, in inverse miniemulsion polymerization, the droplet size is also mainly governed by the nature and the amount of surfactant used. 23 To protect the droplets against Ostwald ripening a strong ''lipophobe,'' like sodium chloride, has to be added. 24 In water-in-oil emulsions, these electrolytes dissolved in the dispersed phase can acts as a second stabilizer.…”