Antiseptics in brain wounds an experimental study of the histological reaction of cerebral tissues to various antiseptic solutions

Russell, Dorothy S.; Falconer, Murray A.

doi:10.1002/bjs.18002811115

Cited by 20 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High-resolution fluorescence imaging of this agent in tissue can yield morphologic information such as the nuclear-to-cytoplasmic ratio which is an important parameter used in the histological diagnosis of cancer. It has a long history of safe clinical use as a topical antiseptic [8] , [9] , and is a component of acriflavine, which has been used in clinical imaging studies of the gastrointestinal tract and cervix [10] , [11] .…”

Section: Introductionmentioning

confidence: 99%

High-Resolution Microendoscopy for the Detection of Cervical Neoplasia in Low-Resource Settings

et al. 2012

View full text Add to dashboard Cite

Cervical cancer is the second leading cause of cancer death among women in developing countries. Developing countries often lack infrastructure, cytotechnologists, and pathologists necessary to implement current screening tools. Due to their low cost and ease of interpretation at the point-of-care, optical imaging technologies may serve as an appropriate solution for cervical cancer screening in low resource settings. We have developed a high-resolution optical imaging system, the High Resolution Microendoscope (HRME), which can be used to interrogate clinically suspicious areas with subcellular spatial resolution, revealing changes in nuclear to cytoplasmic area ratio. In this pilot study carried out at the women's clinic of Princess Marina Hospital in Botswana, 52 unique sites were imaged in 26 patients, and the results were compared to histopathology as a reference standard. Quantitative high resolution imaging achieved a sensitivity and specificity of 86% and 87%, respectively, in differentiating neoplastic (≥CIN 2) tissue from non-neoplastic tissue. These results suggest the potential promise of HRME to assist in the detection of cervical neoplasia in low-resource settings.

show abstract

Section: Introductionmentioning

confidence: 99%

High-Resolution Microendoscopy for the Detection of Cervical Neoplasia in Low-Resource Settings

et al. 2012

View full text Add to dashboard Cite

show abstract

“…However, in the early stages of the 20 th century, no surgeon considered, in comparison with other measures, that antiseptics played more than a minor role in the prevention of infections. [20] Fleming argued against the use of antiseptics to wounds, mentioning that antiseptics result in greater harm. [21,22].…”

Section: Discussionmentioning

confidence: 99%

The Use of Anti-Septic Solutions in the Prevention of Neurosurgical Site Infections

Lefevre¹

2012

Clin Microbial

View full text Add to dashboard Cite

Object: Pre-incisional skin preparation with an antiseptic solution is crucial in preventing SSI. However, a lack of consensus in both general and spine surgery regarding the preference of skin preparation methods continues. The goal of this study is to evaluate the preferred method of pre-operative skin preparation for spine surgery in various academic and non-academic institutions in the United States. Methods: The study data were generated from a telephone survey that emphasized the type of preoperative antiseptic solution used in spinal surgery. The options were: Betadine (povidone-iodine), DuraPrep (iodine-povacrylex and isopropyl alcohol), ChloraPrep (2% chlorhexidine and 70% isopropyl alcohol), and any possible combinations. A total of 128 neurosurgical departments across the United States were contacted, including all 98 ACGME accredited neurosurgical programs. Results were reported on the basis of type antiseptic solution used by each institution and by geographical region based on United States census regional distribution. Results: Most of the neurosurgical centers used DuraPrep followed by ChloraPrep and then Betadine. Thirtyseven centers used various combinations either as a preference in isolated cases or as a combination. The surveyed neurosurgical departments came from all 9 regions in the United States (Pacific, Mountain, West south central, West north central, East north central, East south central, South Atlantic, Middle Atlantic, and New England. ChloraPrep is the preferred choice in 5 regions, whereas DuraPrep is preferred in the other 3 regions. Conclusions: Although most of the literature is in favor of ChloraPrep over Betadine or DuraPrep in reducing SSI, the majority of neurosurgical departments continue to use iodine solutions in spine procedures. C li nical M ic r o b io logy : O p e n Acces s

show abstract

“…In most of this series of cases in which open operation has been carried out, vaseline dressings have been used. This is preferable to the use of the customary antiseptics, and is supported by the work of Dorothy Russell and Falconer 18 which demonstrated the destruction of cerebral tissue that accompanied the use of these antiseptics. They found that " Proflavine sulphate in o-i per cent, isotonic solution buffered to pH 6 -2 is not substantially more injurious to the brain than normal saline."…”

Section: Treatmentmentioning

confidence: 99%

Brain Abscess

Gunn¹,

Suggit²

1942

J. Laryngol. Otol.

View full text Add to dashboard Cite

Antiseptics in brain wounds an experimental study of the histological reaction of cerebral tissues to various antiseptic solutions

Cited by 20 publications

References 32 publications

High-Resolution Microendoscopy for the Detection of Cervical Neoplasia in Low-Resource Settings

High-Resolution Microendoscopy for the Detection of Cervical Neoplasia in Low-Resource Settings

The Use of Anti-Septic Solutions in the Prevention of Neurosurgical Site Infections

Brain Abscess

Contact Info

Product

Resources

About