Antisperm antibodies and human infertility

Etribi, A; Ibrahim, Abdalla; Mahmoud, Kamel Z.; El-Haggar, Sahar Mohamed; T, Hamada; El-Ahmadi, Ibrahim

doi:10.1016/s0015-0282(16)46046-2

Cited by 9 publications

(3 citation statements)

References 17 publications

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“…The correlation of antisperm antibodies (ASA) with some cases of unexplained infertility suggests a role for these antibodies in blocking fertilization. [1][2][3][4][5][6][7][8][9][10][11][12] Sperm antigens are normally protected from the immune system of both sexes. Unique sperm antigens are sequestered from the male immune system by a combination of physical and immunochemical barriers.…”

Section: Introductionmentioning

confidence: 99%

Anti‐Sperm Antibodies from Infertile Patients and their Cognate Sperm Antigens: A Review. Identity Between SAGA‐1, the H6‐3C4 Antigen, and CD52

Diekman

Norton

Westbrook

et al. 2000

American J Rep Immunol

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Section: Introductionmentioning

confidence: 99%

Anti‐Sperm Antibodies from Infertile Patients and their Cognate Sperm Antigens: A Review. Identity Between SAGA‐1, the H6‐3C4 Antigen, and CD52

Diekman

Norton

Westbrook

et al. 2000

American J Rep Immunol

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“…Previous studies on the motility of sperm in men with antisperm antibodies have yielded conflicting results. Various reports (Fjallbrant & Obrant, 1968;Etribi et al, 1982;Upadhyaya, Hibbard & Walker, 1984;Francavilla et al, 1984) have concluded that sperm motility is reduced in men with antisperm antibodies, although other studies (Cerasaro et al, 1985;Haas, 1986) have provided evidence that sperm motility is unaffected by antisperm antibodies. In our opinion, this controversy is due to two main factors.…”

Section: Introductionmentioning

confidence: 99%

Antisperm antibodies and sperm motility: a study using timed exposure photomicrography

et al. 1989

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This study examined the effect of antisperm antibodies on sperm motility. Antisperm antibodies present in seminal plasmas with different sperm agglutinating titres were transferred passively to normal donor sperm, and the effects on movement characteristics (velocity of forward progression, amplitude of lateral head displacement, percentage progressive motility and percentage non-progressive motility) were analysed using timed exposure photomicrography. There was no significant association between sperm movement characteristics and the presence of titre of antisperm antibodies in seminal plasma. Furthermore, no differences were detected between those samples that possessed sperm agglutinating versus sperm immobilizing activity. These findings do not support the common belief that antisperm antibodies are a cause of poor sperm motility in semen.

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“…The correlation of antisperm antibodies (ASA) with some cases of unexplained infertility suggests a role for these antibodies in blocking fertilization [1][2][3][4][5][6][7][8]. The incidence of immunity to sperm in infertile couples is estimated to be 9-36% [4,9].…”

Section: Introductionmentioning

confidence: 99%

Human Sperm Proteome: Immunodominant Sperm Surface Antigens Identified with Sera from Infertile Men and Women1

Shetty

Naaby-Hansen

Shibahara

et al. 1999

Biology of Reproduction

110

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The objective of this study was to identify those immunodominant sperm antigens recognized by antisperm antibodies (ASA) in the serum samples of infertile men and women. High-resolution two-dimensional gel electrophoresis was employed to separate human sperm proteins using isoelectric focusing or nonequilibrium pH gradient electrophoresis, followed by PAGE. Serum samples from 15 infertile male subjects and 6 infertile female subjects that contained ASA as assayed by the immunobead binding test (IBT) were analyzed by Western blotting followed by enhanced chemiluminescence (ECL). Serum samples from 10 fertile subjects (5 males and 5 females) that were ASA negative by IBT were used as controls. The ECL blots were analyzed by computer scanning to compare the immunoreactivity between serum samples from fertile and infertile subjects and to identify the antigens unique to the sera of the infertile subjects; 98 sperm auto- and iso-antigenic protein spots were recognized by sera from infertile males and females but not from fertile subjects. Based on vectorial labeling with 125I at the sperm surface, a subset of 6 auto- and iso-antigens was identified as possibly relevant to antibody-mediated infertility.

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Antisperm antibodies and human infertility

Cited by 9 publications

References 17 publications

Anti‐Sperm Antibodies from Infertile Patients and their Cognate Sperm Antigens: A Review. Identity Between SAGA‐1, the H6‐3C4 Antigen, and CD52

Anti‐Sperm Antibodies from Infertile Patients and their Cognate Sperm Antigens: A Review. Identity Between SAGA‐1, the H6‐3C4 Antigen, and CD52

Antisperm antibodies and sperm motility: a study using timed exposure photomicrography

Human Sperm Proteome: Immunodominant Sperm Surface Antigens Identified with Sera from Infertile Men and Women1

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