Antisperm antibodies: etiology, pathogenesis, diagnosis, and treatment

Mazumdar, Setu; Levine, Adam Seth

doi:10.1016/s0015-0282(98)00302-1

Cited by 136 publications

(70 citation statements)

References 88 publications

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“…In women consulting for infertility, the presence of ASA has been detected in serum, follicular fluid, and cervical mucus (4)(5)(6)(7), accounting for conception failure in numerous cases (8). The ASA have been found to differentially bind to capacitated sperm cells (9,10) and to affect several gamete functions, such as survival and motility (11), acrosomal exocytosis (12)(13)(14), and gamete interaction (15)(16)(17)(18); in addition, evidence suggesting a detrimental effect of ASA on early development of human and mouse embryos has been reported (19)(20)(21).…”

mentioning

confidence: 99%

Acrosin antibodies and infertility. I. Detection of antibodies towards proacrosin/acrosin in women consulting for infertility and evaluation of their effects upon the sperm protease activities

Veaute

Furlong

Bronson

et al. 2009

Fertility and Sterility

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mentioning

confidence: 99%

Acrosin antibodies and infertility. I. Detection of antibodies towards proacrosin/acrosin in women consulting for infertility and evaluation of their effects upon the sperm protease activities

Veaute

Furlong

Bronson

et al. 2009

Fertility and Sterility

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“…Other factors such as mechanical, chemical, or inflammatory lesions of the mucosa in female genital system play an important role [7]. Especially in SLE women the immunosuppressive therapy might affect the likelihood of genital tract infection.…”

Section: Discussionmentioning

confidence: 99%

Screening Tests of Reproductive Immunology in Systemic Lupus Erythematosus

Z¹,

Mocková

Čedíková

2012

Autoimmune Diseases

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Female patients in reproductive age with systemic lupus erythematosus and fertility complications together are observed by rheumatologists, gynecologists, and reproductive immunologists. The paper notes the presence of autoantibodies to zona pellucida, to phospholipids (phosphatidyl serine, phosphatidyl ethanolamine, phosphatidyl inositol, phosphatidyl glycerol, phosphatidic acid, annexin V, beta-2 glycoprotein I, and cardiolipin) and of isoantibodies to sperm cells. Isoantibodies to sperm cells are not significantly predominant, but autoimmunity is well expressed in IgG positivity against phosphatidyl inositol, phosphatidyl ethanolamine, phosphatidyl serine, cardiolipin, and beta-2 glycoprotein I, as well as antizona pellucida antibodies in IgG isotype. According to the levels of autoantibodies we have to choose preventive treatment to protect mother and her foetus.

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“…Whereas vasectomy or other injuries of the excurrent ducts are associated with a high prevalence of antisperm antibodies, only few patients with positive antibody titers were observed among those with a history of mumps orchitis [65,66]. On the other hand, identification of immunodominant autoantigens by means of humoral immunity may help to improve diagnosis, classification and prognosis of testicular inflammatory reactions.…”

Section: Inflammation Of the Human Testismentioning

confidence: 99%

Immune Privilege and Inflammation of the Testis

Schuppe¹,

Meinhardt

2005

Chemical Immunology and Allergy, 2005

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Immune cells are found in considerable numbers within the normal, unaffected testes of mammals, including humans. Located in the interstitial compartment, they are implicated in the mechanisms that make the testis an immunologically privileged site where germ cells are protected from autoimmune attack and foreign tissue grafts may survive for extended periods of time. With regard to normal development and function of the testis, both pro- and antiinflammatory cytokines have been shown to play an important regulatory role. The testicular environment, however, does not preclude immune activation resulting in inflammatory reactions and potential damage. In experimental animals, active immunization with testicular tissue or adoptive transfer of specific T lymphocytes causes autoimmune orchitis. In men, infection and inflammation of the reproductive tract including the testes are widely accepted as important etiological factors of infertility. Whereas symptomatic orchitis due to bacterial or viral infections is considered to be rare, a high prevalence of asymptomatic testicular inflammatory reactions could be demonstrated among infertile males. Despite the patchy distribution of the lesions, inflammation is associated with disruption of testicular function, i.e. spermatogenesis. The pattern of lymphocyte infiltration and concomitant damage of seminiferous tubules supports the concept that activation of autoreactive T cells is involved.

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Antisperm antibodies: etiology, pathogenesis, diagnosis, and treatment

Cited by 136 publications

References 88 publications

Acrosin antibodies and infertility. I. Detection of antibodies towards proacrosin/acrosin in women consulting for infertility and evaluation of their effects upon the sperm protease activities

Acrosin antibodies and infertility. I. Detection of antibodies towards proacrosin/acrosin in women consulting for infertility and evaluation of their effects upon the sperm protease activities

Screening Tests of Reproductive Immunology in Systemic Lupus Erythematosus

Immune Privilege and Inflammation of the Testis

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