Screening Tests of Reproductive Immunology in Systemic Lupus Erythematosus

Z, Ulcová-Gallová; Mocková, Alice; Čedíková, Miroslava

doi:10.1155/2012/812138

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…For women with lupus nephritis, kidney inflammation due to SLE, who become pregnant, the decrease in Tregs, which are needed for a successful pregnancy puts them at an increased risk for PE [61–64]. SLE is also associated with antiphospholipid antibodies (aPLs) which is associated with PE, preterm birth and intrauterine growth restriction (IUGR) [65, 66]. As all of these abovementioned disorders have an underlying theme of chronic inflammation, it can be suggested that when a pathological inflammatory insult is superimposed onto the pro-inflammatory state of pregnancy, more severe complications of pregnancy, such as PE may develop [21].…”

Section: Chronic Inflammation Contributes To Endothelial Dysfunction mentioning

confidence: 99%

Pathophysiology and Current Clinical Management of Preeclampsia

et al. 2017

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Preeclampsia is characterized by blood pressure greater than 140/90 mmHg in the second half of pregnancy. This disease is a major contributor to preterm and low birth weight babies. The early delivery of the baby, which becomes necessary for maintaining maternal well-being, makes pre-eclampsia the leading cause for preterm labor and infant mortality and morbidity. Currently, there is no cure for this pregnancy disorder. The current clinical management of PE is hydralazine with labetalol and magnesium sulfate to slow disease progression and prevent maternal seizure, and hopefully prolong the pregnancy. This review will highlight factors implicated in the pathophysiology of preeclampsia and current treatments for the management of this disease.

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Section: Chronic Inflammation Contributes To Endothelial Dysfunction mentioning

confidence: 99%

Pathophysiology and Current Clinical Management of Preeclampsia

et al. 2017

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“…Antiphospholipid antibodies are associated with miscarriage, fetal death, intrauterine growth restriction (IUGR), preterm birth, and preeclampsia [ 33 ], and an association with recurrent miscarriage has also been reported [ 34 ].…”

Section: Antiphospholipid Antibodiesmentioning

confidence: 99%

Pregnancy Associated with Systemic Lupus Erythematosus: Immune Tolerance in Pregnancy and Its Deficiency in Systemic Lupus Erythematosus—An Immunological Dilemma

Gluhovschi

Petrică

et al. 2015

Journal of Immunology Research

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Pregnancy is a physiological condition that requires immune tolerance to the product of conception. Systemic lupus erythematosus (SLE) is a disease with well-represented immune mechanisms that disturb immune tolerance. The association of pregnancy with systemic lupus erythematosus creates a particular immune environment in which the immune tolerance specific of pregnancy is required to coexist with alterations of the immune system caused by SLE. The main role is played by T regulatory (Treg) cells, which attempt to regulate and adapt the immune system of the mother to the new conditions of pregnancy. Other components of the immune system also participate to maintain maternal-fetal immune tolerance. If the immune system of pregnant women with SLE is not able to maintain maternal immune tolerance to the fetus, pregnancy complications (miscarriage, fetal hypotrophy, and preterm birth) or maternal complications (preeclampsia or activation of SLE, especially in conditions of lupus nephritis) may occur. In certain situations this can be responsible for neonatal lupus. At the same time, it must be noted that during pregnancy, the immune system is able to achieve immune tolerance while maintaining the anti-infectious immune capacity of the mother. Immunological monitoring of pregnancy during SLE, as well as of the mother's disease, is required. It is important to understand immune tolerance to grafts in transplant pathology.

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“…Transient infertility in men with SLE may be associated with methotrexate administration and usually regresses within several months following drug discontinuation [3,[5][6][7]. Some autoantibodies, such as antiphospholipid (APL) antibodies or antisperm antibodies, may exert a significant effect on fertility [15].…”

Section: Fertility Of Patients With Systemic Lupus Erythematosusmentioning

confidence: 99%

“…Przejściowa niepłodność u mężczyzn chorych na TRU może być związana ze stosowaniem metotreksatu i zwykle ustępuje po kilku miesiącach od odstawienia leku [3,[5][6][7]. Istotny wpływ na płodność mogą mieć niektóre autoprzeciwciała, takie jak przeciwciała antyfosfolipidowe (APL) czy przeciwciała przeciwplemnikowe [15]. …”

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Fertility, pregnancy and breastfeeding in systemic lupus erythematosus patients

Majdan¹,

Ostanek²,

Olesińska³

et al. 2014

Reumatologia

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S t r e s z c z e n i eWiększość chorych na toczeń rumieniowaty układowy (TRU) jest w wieku prokreacyjnym. Średni wiek zachorowania na TRU to 29 lat. Inaczej niż w przebiegu reumatoidalnego zapalenia stawów, w czasie ciąży u chorych na TRU choroba pozostaje nadal aktywna lub może nawet dojść do jej zaostrzenia. Ciąża -przygotowanie do niej, przebieg, okres karmienia piersią -stanowi poważne wyzwanie terapeutyczne i organizacyjne dla lekarzy opiekujących się chorymi na TRU. Prowadzenie ciąży oraz okres połogu u chorej na TRU wymaga ścisłej współpracy lekarzy różnych specjalności, w tym przede wszystkim reumatologa i położnika. W pracy zostały przedstawione zalecenia dotyczące przygotowania do ciąży, leczenia choroby podstawowej oraz powikłań ciążowych w czasie ciąży i w okresie karmienia piersią u chorych na TRU. Szczególną uwagę zwrócono na leczenie zgodnie z ostatnio opublikowanymi rekomendacjami dla chorych na toczniowe zapalenie nerek. S u m m a r yThe majority of patients with systemic lupus erythematosus (SLE) are at reproductive age. The mean age of SLE onset is 29 years. In contrast to rheumatoid arthritis, in pregnant patients with SLE the disease is still active or even may be exacerbated. Pregnancy -preparation for it, its course, and the breastfeeding period -is a major therapeutic and organizational challenge for doctors taking care of patients with SLE. The management of pregnancy and puerperium in a patient with SLE requires close cooperation of doctors of various specialities, including in the first place rheumatologists and obstetricians. In the paper the recommendations are presented concerning preparation for pregnancy, treatment of the underlying disease and complications during pregnancy and the breastfeeding period in SLE patients. Particular attention is paid to the treatment according to the recently published recommendations for patients with lupus nephritis.Reumatologia 2014; 52/1 23 Ciąża u chorych na toczeń rumieniowaty układowy WstępToczeń rumieniowaty układowy (TRU) jest chorobą autoimmunizacyjną, na którą chorują przede wszystkim kobiety w wieku, w którym problemy zdrowotne związa-ne z ciążą są bardzo istotne. Średni wiek zachorowania to 29 lat [1][2][3]. Inaczej niż w przebiegu reumatoidalnego zapalenia stawów, w czasie ciąży u chorych na TRU choroba pozostaje nadal aktywna lub nawet może dojść do jej zaostrzenia [3][4][5][6][7]. Właściwe przygotowanie chorej na TRU do ciąży, stosowanie w czasie ciąży odpowiednich leków kontrolujących aktywność choroby oraz monitorowanie aktywności choroby w czasie ciąży istotnie wpłynęło na poprawę rokowania co do pozytywnego przebiegu ciąży u chorych na TRU w ostatnich latach [3-5, 7, 8]. Opublikowane aktualne rekomendacje ACR i EULAR dotyczące postępowania w TRU oraz w toczniowym zapaleniu nerek (TZN) uwzględniają problemy ciążowe u chorych na TRU; określają one również leki, które mogą być stosowane, oraz zasady monitorowania chorych na TRU będących w ciąży [6, 9-13]. Płodność chorych na toczeń rumieniowaty układowyW porównaniu z ogólną populac...

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Screening Tests of Reproductive Immunology in Systemic Lupus Erythematosus

Cited by 4 publications

References 19 publications

Pathophysiology and Current Clinical Management of Preeclampsia

Pathophysiology and Current Clinical Management of Preeclampsia

Pregnancy Associated with Systemic Lupus Erythematosus: Immune Tolerance in Pregnancy and Its Deficiency in Systemic Lupus Erythematosus—An Immunological Dilemma

Fertility, pregnancy and breastfeeding in systemic lupus erythematosus patients

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