Antistaphylococcal and biofilm inhibitory activities of Frangula alnus bark ethyl-acetate extract

Biofilms in Surgical Site Infections: Recent Advances and Novel Prevention and Eradication Strategies

“…Other approaches along with surface modifications have also been explored and focused mainly on compounds that interfere with QS by delivering signal blockers, hindering the production of functional bacterial adhesins, inducing biofilm detachment, and interfering with biofilm regulation mechanisms [ 28 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. Figure 4 details the antimicrobial and more importantly antibiofilm agents and strategic approaches that are currently being explored in several studies to help control biofilm-associated SSIs.…”

“…Nanotechnology-based approaches, predominantly different types of NPs, metal organic frameworks (MOFs), and other nanomaterials, are also amongst the most studied line of attack to deal with pathogenic biofilms [ 22 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 35 , 36 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ]. Natural plant-based products are being developed to help overcome the problem with multidrug-resistant bacteria, namely plant extracts and isolated compounds, as well as essential oils that contain large amounts of phytochemicals [ 33 , 34 , 37 , 38 , 39 , 40 , 41 , 42 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. In addition, physical approaches (cryogenic freezing, ultrasound), bacteriophages, electrochemical treatments, photodynamic therapy (PDT), combination approaches, and other strategies are also among a few other examples that are being presently implemented [ 26 , 30 , ...…”

“…Other studies that included plant extracts were performed recently (see Supplementary Materials Table S1 ). One of those was conducted by Đukanović et al [ 38 ], where the researchers investigated the antibacterial and antibiofilm activities of the Frangula angus ethyl-acetate bark extract towards S. aureus strains and clinical isolates from surgical wounds, blood, and the nasal carriage. The authors demonstrated the extracts’ influence on cell respiration in both planktonic and biofilm forms.…”

“…Regarding the composition of the F. angus extract, several qualitative and quantitative analyses were performed, which overall allowed the researchers to evidence the presence of phenols, flavonoids, and emodin, whereas catechin and 4-ethoxy benzoic acid were the most prevailing compounds. Moreover, the results obtained in this work showed that F. angus possesses strong potentiality since it prevented biofilm formation and disrupted pre-established biofilms in almost all tested strains, suggesting its promising applications in developing new strategies for controlling biofilm growth in nosocomial infections [ 38 ]. A study carried by Nadaf et al [ 59 ] explored the antimicrobial, antibiofilm, and also antioxidant activities of Hymenocallis littoralis methanolic leaf extracts against pathogenic microorganisms, using experimental and computational biology approaches.…”

Chemical composition and antibacterial activity of 12 medicinal plant ethyl acetate extracts using LC–MS feature‐based molecular networking

“…leaves has remarkable anti‐inflammatory and antioxidant activity based on the high total phenolic compound contents (413 ± 4 μg GAE/mg) and triterpenoid contents (70.4 ± 1.8 μg UAE/mg) 19 . Frangula alnus bark EA extract could be used as potential antibiofilm agents against Staphylococcus aureus for its effective inhibition 20 . Furthermore, evaluation of the bioactive phytochemicals is always a strong point in plant research.…”