Antistreptolysin Content of Blood Serum of Children. Its Significance in Rheumatic Fever

The relation of upper respiratory infections to rheumatic fever in children. II. Antihemolysin titres in respiratory infections and their significance in rheumatic fever in children

“…In this study the basal values obtained for 80 rheumatic subjects during apparent health showed a range of from 25 to 715 units with an average of 135 units. This is somewhat lower than that observed in our preliminary study (6). The opportunity for special selection of subjects and the longer period of observation probably accounts for this difference.…”

Studies on the Immune Response of the Rheumatic Subject and Its Relationship to Activity of the Rheumatic Process. Vi. The Significance of the Rise of Antistreptolysin Level in the Development of Rheumatic Activity 1

“…In general, the greater the antibody response, the more severe the accompanying rheumatic attack; and conversely, in the absence of antibody response the rheumatic attack fails to develop. The 7 The authors are indebted to Dr. A. A. Weech for advice in applying statistical methods to these data.…”

The Relation of Upper Respiratory Infections to Rheumatic Fever in Children

“…Wilson, Wheeler and Leask (6), in a preliminary report on the antistreptolysin content of the serum in children, found that this antibody apparently passes through the placenta, being present in new-born infants. An analysis of the average titres for various age groups indicated a definite age correlation, the lowest values being obtained in the age period between three months and three years.…”