Antisynthetase syndrome associated with long-standing rheumatoid arthritis

Autoantibodies to extractable nuclear antigens (ENAs) pattern in rheumatoid arthritis patients: Relevance and clinical implications

“…5,36 Only a few case reports describe ASS complicating the course of RA. [5][6][7][8][9][10][11] In general, there is little justification for requesting tests for anti-ENA autoantibodies unless the ANA test is positive. Previously was recommended to perform an initial ANA screening test followed by confirmatory anti-ENA and anti-dsDNA antibody, if needed.…”

“…Although RA and ASS are distinct clinical syndromes, their co-occurrence may be rarely encountered and by early diagnosis serious or even fatal ILD can be prevented by early and appropriate treatment. [5][6][7][8][9][10] A limitation of our study is that many studies were done regarding ENA autoantibodies including ANA, anti-Ro and anti-La in relation to secondary Sjogren's syndrome. The strength of our study is that only few studies have systematically investigated the different types of autoantibodies against ENA in a large series of RA patients correlating the findings with clinical manifestations.…”

“…[2][3][4] The presence of anti-Jo-1 in RA patients may indicate an overlap between RA and anti-synthetase syndrome (ASS) especially in anticitrullinated peptide/protein antibodies (ACPA) positive cases. [5][6][7][8][9][10][11] Extractable nuclear antigens (ENAs) are autoantibodies that react with proteins in the cell nucleus, these proteins collectively termed "extractable" because they can be isolated from cell nuclei using saline. Autoantibodies directed to intracellular components are a characteristic feature of antinuclear antibody (ANA)associated rheumatic diseases (AARD), like systemic lupus erythematosus (SLE), systemic sclerosis (SSc), mixed connective tissue disease (MCTD), primary Sjögren syndrome (pSS), and autoimmune inflammatory myositis (AIM).…”

Sonographic findings from inflammatory arthritis due to antisynthetase syndrome

“…Among the extra-muscular manifestations of ASyS, less attention has been drawn to the joint involvement, even though approximately 70% of patients develop arthralgia or arthritis during the course of their disease [2][3][4]. Polyarthritis may be the initial manifestation often leading to an initial diagnosis of rheumatoid arthritis [5,6]. In fact, 445 of 636 (64%) ASyS had polyarticular, symmetrical arthritis from disease onset in the American and European Network of Antisynthetase Syndrome (AENEAS network) [2].…”

Dermatomyositis in Patients with Rheumatoid Arthritis During Adalimumab Therapy

“…RA can precede myositis, or it can develop after the diagnosis of PM/DM 3 . We previously reported 2 patients with RA who were not receiving anti-TNF therapy, but developed anti-Jo-1 antibody-positive PM and DM 4,5 . In these 2 patients, onset of RA preceded that of DM or PM by 1 and 19 years, respectively, which suggests that PM/DM can develop at any time during the course of RA.…”