Antithrombin activity of some constituents from Origanum vulgare

Goun, Elena A.; Cunningham, Glenn N.; Solodnikov, S. Yu.; Krasnykch, O.; Miles, Howard

doi:10.1016/s0367-326x(02)00245-9

Cited by 36 publications

(22 citation statements)

References 6 publications

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“…(Hu et al, 2004), have cytotoxic effect against numerous cancer cell lines (Viel & Dore, 1972;Wu et al, 1999Wu et al, , 2000Goun et al, 2002). Thin layer chromatography examination of the three active extracts of A. baetica indicated the presence of aristolochic acid I. Consequently, the responsible compound for the antiproliferative effect of this plant, shown in our study, seems to be aristolochic acid I.…”

Section: Discussionmentioning

confidence: 78%

Antiproliferative effect of extracts fromAristolochia baeticaandOriganum compactumon human breast cancer cell line MCF-7

Chaouki

Léger

Eljastimi³

et al. 2010

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 78%

Antiproliferative effect of extracts fromAristolochia baeticaandOriganum compactumon human breast cancer cell line MCF-7

Chaouki

Léger

Eljastimi³

et al. 2010

Pharmaceutical Biology

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“…1 Due to the variability in chemical and aroma composition, Origanum plants are widely used as a culinary herb, to flavour food products and alcoholic beverages 2 and for their pharmacological properties, including antibacterial, antioxidant, antithrombin and antihyperglycaemic activities. [3][4][5][6] Origanum species have continuously been studied for their essential oil composition as potential sources of antimicrobial and antioxidant natural agents. On the basis of these studies, as well as the prevalence of the main compounds, Origanum taxa can be divided in three groups: (a) linalool, terpinen-4-ol and sabinene hydrate group; (b) carvacrol and/or thymol group; (c) sesquiterpenes group.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, antimicrobial and antioxidant activities of the essential oil of several populations of Algerian Origanum glandulosum Desf.

Sari

Biondi

Kaabeche

et al. 2006

Flavour & Fragrance J

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Essential oils extracted by hydrodistillation from the aerial parts of 23 samples of Algerian Origanum glandulosum Desf. were analysed by gas chromatography (GC) and GC-mass spectrometry (MS). Overall, 30 components have been fully characterized. However, all the oils were characterized by the predominance of four components, thymol (18.5-73.1%), carvacrol (7.6-72.6%), p-cymene (1.7-18.5%) and γ γ γ γ γ -terpinene (1.1-18.7%). Cluster analysis of the identified components allowed us to establish the presence of three main groups, characterized by carvacrol, thymol and comparable amounts of both compounds, respectively. The free radical scavenging activity of essential oils was determined by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) model system. The SC 50 (scavenging concentration) values were in the range 16.2-26.7 µ µ µ µ µg/ml, representing a good antioxidant effectiveness. The roles of thymol and carvacrol, the main components of all oils, were estimated by measuring their stoichiometric factors. The essential oils were also evaluated for their antimicrobial activity by the agar disc diffusion method and the determination of minimum inhibitory concentration (MIC) against six standard strains (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus hirae, Candida albicans, Candida tropicalis). All microbial strains employed (Gram-positive and Gram-negative bacteria and yeasts) showed a fairly similar degree of susceptibility to the essential oils under investigation, although no evident difference was observed in their sensitivity. Furthermore, a similar level of toxicity was observed for all oils examined, with MIC values of 31.25-125.00 µ µ µ µ µg/ml. Finally, the addition of the emulsifier Tween 80 to the oil or to the agar markedly decreases the antimicrobial activity of the essential oils against all microbial strains employed, thus suggesting that the antimicrobial activity of the essential oils is dependent on the physicochemical characteristics of their components and also on the microbial strains employed.

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“…Also have different pharmacological activities not only as preventive but also as a treatment of some diseases with full relief of their symptoms [11]. The current research studies introduced many antihypertensive agents with limited adverse side effects, however the recognition of herbal remedies as another therapeutic alternatives (anti-thrombin activities) have been considered as an important goal for the pharmaceutical industries through their components [12]. Origanum vulgare displayed anti-platelet properties in human, has a role in controlling blood sugar and also inhibits abnormal cell growth, it also helps in maintaining healthy cholesterol and blood pressure [13] and is widely distributed through different regions as Morocco, Russa and Egypt [14].…”

Section: Introductionmentioning

confidence: 99%

“…The main pharmacological effects of Origanum vulgare are being anti-oxidant, anti-thrombin and potent anti-hypertensive through maintaining renal function, creatinine clearance and inhibiting mechanical forces acting on arterial wall so preventing excess hardening and thickening [12,15].…”

Section: Introductionmentioning

confidence: 99%

Histological, Immunohistochemical and Biochemical Study on the Possible Cardioprotective and Antihypertensive Role of the Flavonoid in Unilateral Renal Artery Ligation of Adult Albino Rats

Mohamed¹

2015

J Cytol Histol

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The blood pressure lowering effect of herbal-rich diet is a necessary dietary lifestyle measure now included the guidelines for the management of arterial hypertension. Flavonoids represent a major class of plant polyphenolics, they have antioxidant effects and show a wide range of pharmacological activities. This study was to clarify the antihypertensive effect of the flavonoid extracted from the Origanum vulgare.Forty five adult male albino rats were classified into three main groups as follows: group I: control. Group II: hypertension was induced by ligation of left renal artery. Group III: hypertension was induced and given OV as 100 mg/kg body weight daily for eight weeks. Blood samples were collected and cardiac sections were stained with H&E and immunohistochemical staining for caspase 3 and Bcl-2.The body weight of control, hypertensive and treated hypertensive groups showed a significant weight gain. Significant increase in creatinine and cholesterol in untreated in contrast to other groups. There was significant reduction of blood pressure (BP) on using OV in contrast to other groups. The hypertension group induced myocardial abnormalities as disruption, vacuolation, inflammation and wide separation of cardiac muscle fibers. Myocyte apoptosis were significantly decreased with OV compared with other groups. Caspases 3 and Bcl2 immunostaining in OV-treated rats were significantly decreased compared with other groups.The supplementation of OV herbetic extract (flavonoid) in hypertensive rats partially prevented such occurred changes, suggesting its possible protective effect against the risk of the progression of cardiovascular diseases during hypertension.

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Antithrombin activity of some constituents from Origanum vulgare

Cited by 36 publications

References 6 publications

Antiproliferative effect of extracts fromAristolochia baeticaandOriganum compactumon human breast cancer cell line MCF-7

Antiproliferative effect of extracts fromAristolochia baeticaandOriganum compactumon human breast cancer cell line MCF-7

Chemical composition, antimicrobial and antioxidant activities of the essential oil of several populations of Algerian Origanum glandulosum Desf.

Histological, Immunohistochemical and Biochemical Study on the Possible Cardioprotective and Antihypertensive Role of the Flavonoid in Unilateral Renal Artery Ligation of Adult Albino Rats

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