Antithrombin III in normal pregnancy

Weenink, G.H.; Treffers, P.E.; Kahlé, L.H.; Cate, J. W. Ten

doi:10.1016/0049-3848(82)90293-6

Cited by 45 publications

(15 citation statements)

References 19 publications

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“…Previously, we were unable to find a significant AT III decrease in normal pregnancy [ Weenink et al, 1982], In our present study, 61 patients without hypertension had a slightly (0.05 U/ml) but significantly lower mean AT III level at 37-42 weeks than their own mean control value 6-8 weeks after delivery. However, this small decrease is of little clinical rele vance, and the mean value is still above that of the reference pool plasma.…”

Section: Discussionmentioning

confidence: 44%

Antithrombin III Levels in Normotensive and Hypertensive Pregnancy

Weenink¹,

Borm²,

Cate³

et al. 1983

Gynecol Obstet Invest

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Antithrombin III (AT III) is the main physiological inhibitor of blood coagulation. In a prospective study, plasma AT III was determined in 653 women during pregnancy, using an automated amidolytic technique. A control value 8 weeks after delivery was obtained in 192 of the women. In women with pregnancy-induced or aggravated hypertension a significant decrease in AT III levels was observed compared with normotensive controls of the same period of gestation and compared with the patients’ own control values 6–8 weeks after delivery. No AT III depression occurred in patients with chronic hypertension during pregnancy. Patients with pregnancy hypertension and proteinuria had lower AT III levels than those without proteinuria, whose AT III levels were also depressed. Lowest AT III levels were seen in 2 eclamptic patients and in patients with severe preeclampsia, whose pregnancies were terminated for fetal distress while the infants were still preterm. Monitoring AT III levels is of value in preeclampsia.

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Section: Discussionmentioning

confidence: 44%

Antithrombin III Levels in Normotensive and Hypertensive Pregnancy

Weenink¹,

Borm²,

Cate³

et al. 1983

Gynecol Obstet Invest

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“…In normal pregnancy, coagulation factors are increased, and activation of the coagulation system takes place leading to significant increase of TAT but AT III levels remain within normal limits as production of AT III outweighs its consumption [17,18,26]. In normal pregnancy, increased coagulation factors are inactivated by the physiological inhibitors in the blood and therefore intravascular coagulation does not occur.…”

Section: Discussionmentioning

confidence: 99%

The value of antithrombin-III and fibronectin in hypertensive disorders of pregnancy

Chen¹,

Madazh²,

Kavuzlu³

et al. 1994

Jpme

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In this study we evaluated fibronectin as a marker of endothelial cell injury and antithrombin III as a marker of chronic activation of intravascular coagulation. The aim of the study was to establish to normal trends of plasma antithrombin III and fibronectin in general obstetric population and to determine the value of both in predicting, distinguishing and understanding the pathophysiology of pregnancy induced hypertension. The all cases consisted of 173 pregnant, 19 of them were chronic hypertensive, 45 were pregnancy induced hypertensive and 119 were normotensive at blood sampling. Out of 119 normotensive cases, 109 cases had no adverse outcome during their pregnancy. These cases were used as a control group and for the normal trends of antithrombin III and fibronectin in general obstetric population. Ten out of 119 cases who developed preeclampsia during follow up, 19 cases with chronic hypertension and 45 cases with pregnancy induced hypertension consisted of the study group. In the cases who developed preeclampsia during follow up, the value of plasma fibronectin level (above 95% confidence limit for that gestational week) to predict preeclampsia had 90% sensitivity and 94.4% specificity. In distinguishing hypertensive disorders of pregnancy (chronic hypertension or pregnancy induced hypertension) fibronectin had 71.1% sensitivity and 100% specificity. Plasma antithrombin III level (of antigenicity) measured by immunodiffusion method had no value in predicting and distinguishing pregnancy induced hypertension.

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“…Such elevated ratios are common in normal pregnancy 14,22,23 and are indicative of thrombin-induced loss of factor VIII:C activity as a consequence of activation of the coagulation system and thrombin generation. 14 Weenink et al, 24 using the chromogenic substrate (S 2238) assay we used in this study, found no significant variation in the antithrombin III concentration throughout pregnancy and Puerperium compared to nonpregnant levels. A similar conclusion was reported more recently by Stirling et al 14 Our finding of a slight but statistically significant decrease in antithrombin III levels in the second and third trimesters of pregnancy confirms other reports 22,25 and could be other indirect evidence of thrombin generation.…”

Section: Discussionmentioning

confidence: 99%

Hemostasis in Pregnant Saudi Women

et al. 1990

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A cross-sectional study of various hemostatic variables was undertaken in women during the three trimesters of normal pregnancy. In the third trimester of pregnancy, there was significant elevation of plasma fibrinogen, 55%; factor VIII activities, 64%; factor VIII:ristocetin cofactor, 44% ; factor VIII-related antigen, 49% ; factor X, 9% ; and plasminogen, 19%, and a reduction of antithrombin III, 10%; alpha2-antiplasmin, 7%; and platelet count, 20%, compared with those values obtained in healthy nonpregnant controls. These fluctuations developed gradually during the first and second trimesters. Prothrombin time, partial thromboplastin time, thrombin time, and reptilase time were similar in pregnant women and nonpregnant controls. Platelet aggregation in response to adenosine diphosphate, collagen, adrenaline, and arachidonic acid was significantly reduced in pregnant women compared to controls. The reduced platelet aggregability in Saudi pregnant women may counterbalance the increased plasmatic coagulation potential, thereby minimizing the risk of thromboembolic disease during pregnancy.

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Antithrombin III in normal pregnancy

Cited by 45 publications

References 19 publications

Antithrombin III Levels in Normotensive and Hypertensive Pregnancy

Antithrombin III Levels in Normotensive and Hypertensive Pregnancy

The value of antithrombin-III and fibronectin in hypertensive disorders of pregnancy

Hemostasis in Pregnant Saudi Women

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